Cancer Research - Europa

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AIDIT Advancing International Co-operation and Developing Infrastructure for Targeted Screening of Prostate Cancer in Men with Genetic Predisposition Summary In the EU, approximately 200 000 men are diagnosed annually with prostate cancer, and this fi gure is likely to increase due to the ageing population, which will cause a considerable healthcare problem. Inherited genetic factors are important in this disease, for example the breast cancer predisposition genes BRCA1 and BRCA2 have been reported to increase the risk of prostate cancer signifi cantly. The European IMPACT study (scheduled to begin in 2005) aims to put in place networks and infrastructures in 23 countries (18 of them in Europe) to identify a male population harbouring germ line mutations in the BRCA1 and BRCA2 genes, and recruit them into targeted screening programmes for prostate cancer. IMPACT also aims to support future research into the targeted screening and clinical management of prostate cancer in high-risk individuals. The main goal of this proposal (AIDIT) is to stimulate cooperation with Associated Candidate Countries (ACCs) in relation to the IMPACT study. It is intended that a Specifi c Support Action (SSA) could provide the means to identify and recruit appropriate centres in the ACCs; stimulate the participation of research teams in ACCs and connect expertise in all collaborating countries in this area. Networking and dissemination of the latest results from ongoing prostate cancer screening studies are crucial elements of this proposal, which has the long-term aim of enabling centres in the ACCs to join the IMPACT study, thus establishing a larger consortium and research base. AIDIT is also aimed at raising the profi le of the need to improve clinical management of prostate cancer, educating the relevant stakeholders, improving quality of life, reducing early mortality and reducing the fi nancial burden of healthcare. It will consider relevant gender, ethical and societal issues, supporting the implementation of the Sixth Framework Programme and, in particular, the Combating Cancer topic of Thematic Priority 1. AIDIT can only occur under the auspices of an EU SSA. 86 Keywords | Prostate cancer | BRCA1 | BRCA2 | targeted screening | associate candidate countries | Problem Prostate cancer is a common cancer in men but the cause of the disease remains a mystery. There is a potential for improving patient management and for reducing early mortality by targeting screening for prostate cancer. Studies have indicated that BRCA1 and BRCA2 genes signifi cantly increase the risk of prostate cancer but further work is needed in the area to determine the exact risks of this patient population. International collaboration has been established in 23 countries worldwide but out of the Associate Candidate Countries only one centre in Turkey is involved. Aim To expand the IMPACT study collaboration into the Associate Candidate Countries through advertising the study both to the general population and to researchers using media, establishing a website and holding an international conference. Expected results • To host an international conference to bring all collaborators together and meet and share knowledge. • To identify and recruit new centres in ACCs. • To recruit ACC members onto the IMPACT study, and specialist and steering committees. • To increase awareness of the BRCA1/2 link to prostate cancer and encourage genetic testing in individuals at risk. • Development of a centralised website. • To raise the profi le of the need for increased detection of mutations in BRCA1 and BRCA2 in men, and for improved clinical management of prostate cancer in the ACCs. • To educate the relevant stakeholders through the creation of reliable, informative, and fast communication hardware and software systems. Potential applications • Promote future research collaborations between teams in these countries and the current IMPACT consortium. • To assist in guiding future clinical management of men with BRCA1 and BRCA2 mutations. CANCER RESEARCH PROJECTS FUNDED UNDER THE SIXTH FRAMEWORK PROGRAMME
Coordinator Rosalind Eeles Reader in Clinical Cancer Genetics and Honorary Consultant in Cancer Genetics and Clinical Oncology Cancer Genetics Unit Institute of Cancer Research/ Royal Marsden NHS Trust Sutton, United Kingdom rosalind.eeles@icr.ac.uk INDICENCE OF PROSTATE CANCER: ASR (WORLD) (ALL AGES) ■ ‹ 5.9 ■ ‹ 14.1 ■ ‹ 22.1 ■ ‹ 31.0 ■ ‹ 95.1 GLOBOCAN (IARC 1998) Partners Jan Lubinski International Hereditary Cancer Centre Pomeranian Medical University Szczecin, Poland lubinski@sci.pam.szczecin.pl Guven Luleci Akdeniz University Faculty of Medicine Departments of Medical Biology and Genetics Antalya, Turkey luleci@akdeniz.edu.tr Project number LSSM-CT-2005-018686 EC contribution € 330 057 Duration 18 months Starting date 01/12/2005 Instrument SSA Project website Under construction AETIOLOGY 87
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PROJECT SYNOPSES CANCER RESEARCH PR
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CANCER RESEARCH PROJECTS FUNDED UND
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TABLE OF CONTENTS FOREWORD - CANCER
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Prevention 97 EPIC 98 EUROCADET 100
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CANCER: COMBATING A COMPLEX DISEASE
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Biology Cancer is a disease ethat t
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p53 activators ASPP Partner 5 NFkap
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Keywords | Angiogenesis | vasculoge
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Keywords | Tumour-host interactions
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Keywords | Breast | metastasis | ge
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Keywords | Identifi cation of novel
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Keywords | Systems biology | modell
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Keywords | Oncology | anticancer th
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• public health research coupled
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Expected results We will construct
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Potential applications Our DNA is u
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Microscopic examination of tissue s
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Pluripotent embryonic stem cells ar
Page 37 and 38: • Decryption of the leukaemia cel
Page 39 and 40: • identifi cation of molecular ta
Page 41 and 42: A B C LT-HSC CSC The Cancer Stem Ce
Page 43 and 44: X-ray diff raction of target drug c
Page 45 and 46: using pathway-specifi c reporter ce
Page 47 and 48: Keywords | Kinases | pediatric panc
Page 49 and 50: Keywords | Lymphangiogenesis | angi
Page 51 and 52: Keywords | Breast cancer | metastas
Page 53 and 54: Keywords | Mitosis | phosphorylatio
Page 55 and 56: Keywords | Therapy | genome | telom
Page 57 and 58: Keywords | Multiple myeloma | cance
Page 59 and 60: Keywords | p53 tumour suppressor |
Page 61 and 62: Development of eff ective anti-canc
Page 63 and 64: Coordinator Patrick A. Curmi INSERM
Page 65 and 66: Drosophila as a model system for tu
Page 67 and 68: Normal cell growth and epithelial l
Page 69 and 70: effi ciently with cancer cell proli
Page 71 and 72: A high-throughput assay of transcri
Page 73 and 74: Coordinator Ewa Sikora Nencki Insti
Page 75 and 76: Expected results The SIROCCO consor
Page 77 and 78: Keywords | Epigenetics | gene regul
Page 79 and 80: Keywords | Hereditary | tricarboxyl
Page 81 and 82: Keywords | HSV-1 | hepatocellular c
Page 83 and 84: Keywords | Apoptosis | autophagy |
Page 85 and 86: Keywords | Tumour | host | signalli
Page 87: Aetiology The uncontrolled cell gro
Page 91 and 92: The parallelogram approach in CARCI
Page 93 and 94: Keywords | Melanoma | genetics | na
Page 95 and 96: Keywords | Virus | bacteria | HPV |
Page 97 and 98: Keywords | Breast | prostate | gene
Page 99 and 100: Prevention The fact that preventing
Page 101 and 102: Coordinator Elio Riboli Imperial Co
Page 103 and 104: Coordinator Jan Willem Coebergh Joh
Page 105: Coordinator Jose M a Benlloch Conse
Page 108 and 109: BAMOD Breath-Gas Analysis for Molec
Page 110 and 111: BioCare Molecular Imaging for Biolo
Page 112 and 113: These centres of excellence will in
Page 114 and 115: Expected results Optimise the benef
Page 116 and 117: 114 Cell proliferation and apoptosi
Page 118 and 119: COBRED Colon and Breast cancer Diag
Page 120 and 121: DASIM Diagnostic Applications of Sy
Page 122 and 123: Expected results Primarily, the res
Page 124 and 125: Coordinator John A. Foekens Dept. o
Page 126 and 127: 124 Aim Drop-Top has two major obje
Page 128 and 129: Coordinator Gorka Ochoa Progenika B
Page 130 and 131: Expected results The E.E.T.-Pipelin
Page 132 and 133: e developed by eTUMOUR is likely to
Page 134 and 135: Coordinator Angel Porgador Ben-Guri
Page 136 and 137: • the design of a compact assembl
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Potential applications We believe t
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Tumor initiation, progression to ma
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MolDiag-Paca Novel Molecular Diagno
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NEMO Nano based capsule-Endoscopy w
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OVCAD Ovarian Cancer - Diagnosis of
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P-MARK Validation of recently devel
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POC4life Multiparametric quantum do
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PROMET Prostate cancer molecular-or
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Micrometastasis in the bone marrow.
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and pharmaco-kinetics studies. This
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Coordinator Raffaella Giavazzi Isti
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• Development of tools for diagno
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Treatment Two major problems when t
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Coordinator Lluis M. Mir UMR 8121 C
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Potential applications ANGIOSTOP ha
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Green-fl uorescence protein- expres
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Coordinator Robert Hawkins Universi
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Expected results The BACULOGENES pr
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descriptors of the molecules to be
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Keywords | Therapeutic vaccine | im
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Keywords | Cancer chemotherapy | dr
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Keywords | Children | cancer | leuk
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Chimaeric TCR shown in context of n
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Andrea Splendiani Leaf Bioscience s
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Coordinator Anne O’Garra The Medi
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Coordinator Jacques Bartholeyns IDM
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Structure Driven Drug Design The in
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• acquire fundamental knowledge a
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Terry Jones Victoria University of
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Potential applications The use of t
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groups and management structures. T
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T. Barbui Azienda Ospedaliera-Osped
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Keywords | Mantle cell lymphoma | t
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Keywords | Hypoxia | HIF | pericell
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Keywords | Radiation-induced compli
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Keywords | Gene therapy | adenoviru
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Keywords | Dependence receptors | a
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Keywords | Photodynamic therapy | a
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Keywords | Ovarian cancer | thymidy
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Keywords | Quality assurance | clin
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Keywords | Circadian | clocks | cel
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Keywords | Anticancer therapy | onc
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Coordinator Monika Lusky Transgene
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6 000 women over a three-year perio
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Keywords | Solid tumours | apoptosi
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Keywords | Lymphoma | leukaemia | v
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Coordinator Riccardo Dolcetti Centr
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CCPRB Cancer Control using Populati
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EPCRC The European Palliative Care
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EUROCAN+PLUS Feasibility Study for
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EUSTIR A European strategy for the
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NORMOLIFE Development of new therap
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Scientifi c Model Systems The compl
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Performance of benchmarking exercis
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• markers correlating with the im
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Indices - Keywords Indices - Partne
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● disease markers 131 ● DNA dam
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● renal 77 ● replication 219
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Bos, Nico A. 56 Boskovic, Darinka 2
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Geley, Stephan 159 Georgopoulos, Li
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Lingner, Joachim 54 Linial, Michal
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Ragno, Pia 115 Rainford, Martyn 92
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Vernos, Isabelle 22 Veronesi, Umber
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● Centre Hospitalier Universitair
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● IFOM - Fondazione Istituto FIRC
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● National University of Ireland
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● University of Bari 174 ● Univ
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HOW TO OBTAIN EU PUBLICATIONS Our p
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