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80<br />
Expected results<br />
We will investigate diff erent ways of producing HSV-1 vectors<br />
conceived to penetrate specifi cally, express genes and<br />
replicate into HCC, therefore killing these cells and allowing<br />
the spread of the virus to infect other tumour cells. In addition<br />
to their inherent targeted oncolytic potential, these<br />
vectors will express enhancing transgenic sequences, encoding<br />
immune-modulators, anti-angiogenic molecules, fusion<br />
proteins, or toxic proteins, which are expected to have an<br />
additive negative action on tumour growth. Our expectation<br />
is to produce, by the end of the project, a number of such<br />
vectors, combining targeting and enhancing functions,<br />
which will be fully evaluated for effi cacy and toxicity on different<br />
HCC animal models, including standard and transgenic<br />
mice, and woodchucks.<br />
Potential applications<br />
Treatment of primary liver cancers (hepatocellular carcinomas).<br />
Coordinator<br />
Alberto L. Epstein<br />
Centre de Génétique Moléculaire<br />
et Cellulaire<br />
CGMC – UMR 5534 – CNRS<br />
Université Claude Bernard Lyon 1<br />
Villeurbanne, France<br />
epstein@cgmc.univ-lyon1.fr<br />
Partners<br />
Thomas Brocker<br />
Ludwig-Maximilians-Universität München<br />
Institute for Immunology<br />
Munich, Germany<br />
tbrocker@med.uni-muenchen.de<br />
Roberto Manservigi<br />
Università degli Studi di Ferrara<br />
Dipartimento di Medicina Sperimentale<br />
e Diagnostica<br />
Sezione di Microbiologia<br />
Ferrara, Italy<br />
mns@unife.it<br />
Penelope Mavromara<br />
Hellenic Pasteur Institute<br />
Athens, Greece<br />
penelopm@hol.gr<br />
Ruben Hernandez Alcoceba<br />
Fernando Corrales<br />
Fundacion para la investigacion<br />
medica aplicada<br />
Pamplona, Spain<br />
rubenh@unav.es<br />
fjcorrales@unav.es<br />
Andres Crespo<br />
Genopoietic<br />
Miribel, France<br />
andrescrespo@aol.com<br />
Jean-Jacques Diaz<br />
Centre de Génétique Moléculaire<br />
et Cellulaire<br />
Université Claude Bernard Lyon 1<br />
Villeurbanne, France<br />
diaz@cgmc.univ-lyon1.fr<br />
Project number<br />
LSHB-CT-2005-018649<br />
EC contribution<br />
€ 2 494 460<br />
Duration<br />
36 months<br />
Starting date<br />
01/01/2006<br />
Instrument<br />
STREP<br />
Project website<br />
www.tholven.eu<br />
CANCER RESEARCH PROJECTS FUNDED UNDER THE SIXTH FRAMEWORK PROGRAMME
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