Cancer Research - Europa

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EMIL 190 ENACT 194 European LeukaemiaNet 196 European MCL Network 201 EUROXY 203 FIRST 205 GIANT 207 HERMIONE 209 Immuno-PDT 2 1 1 LIGHTS 2 1 3 MAESTRO 2 1 5 TEMPO 2 1 7 THERADPOX 219 TRANSBIG 222 TRIDENT 225 VITAL 227 Cancer control, Survivorship and outcomes research 231 CCPRB 232 EPCRC 234 EUROCAN+PLUS 236 EUSTIR 238 NORMOLIFE 240 Scientifi c Model Systems 243 ESBIC-D 244 ZF-TOOLS 246 6 CANCER RESEARCH PROJECTS FUNDED UNDER THE SIXTH FRAMEWORK PROGRAMME
CANCER: COMBATING A COMPLEX DISEASE Human cancer is one of the oldest documented diseases. The oldest written evidence of the disease is found in Egyptian papyri from the period 3 000 to 1 500 BC which describe ulcers and breast cancer. The oldest specimen is a bronze age (1900-1600 BC) female skull suggesting head and neck cancer, whereas skeletal remains of a Peruvian – INCA – woman suggest melanoma. Breast cancer, melanoma, as well as head and neck cancer and other solid cancers, are still present across the world today. Cancer is an increasingly important health burden, both for patients and public health systems with signifi cant societal and psychological consequences. In recognition of this, a global eff ort to fi ght and control cancer has been set. Recently, the European Parliament published a resolution on Combating cancer in the enlarged Europe ( 1) and the council of the European Union in its conclusions on reducing the burden on cancer ( 2), invited the European Commission to extend knowledge of cancer epidemiology and cancer risk factors, early detection, diagnosis, treatment, survival and palliative care, as well as to include translational research under the Seventh Framework Programme. In addition, the World cancer declaration 2008, calls for a concerted strategic action to reduce the global cancer burden and outlines the steps needed to begin to reverse the global cancer crisis by 2020. Moreover, it sets specifi c priority actions on health policy, prevention and early detection, cancer treatment, and cancer research ( 3). The European Union’s strong research community is well placed to advance the understanding and treatment of cancer. Traditional approaches such as surgery, radiotherapy and chemotherapy are constantly improving, whilst genomic and immunological research off er innovative prospects for future treatment. In addition, new screening and detection methods are making it possible to confront the disease at an increasingly early stage. Furthermore, palliative care is increasingly recognised as important in ensuring cancer patients and their families to receive the best possible care and quality of life. The European Union supports cancer research in order to prevent cancer and to improve patients’ survival chances and their quality of life. The ‘Combating Cancer’ initiative was part of the EU’s Combating Major Diseases research. Within the ‘Life Sciences, Genomics and Biotechnology for Health’ thematic priority of the Sixth Framework Programme, 2002-2006 some € 480 million of funding for cancer research has been made available to the European research community through the programme. It aimed to combat cancer by developing improved patient-oriented strategies, from prevention to earlier and more eff ective diagnosis, to better treatment with minimal side eff ects. It supported initiatives aimed at translating knowledge of basic research into applications to improve clinical practice and public health actions. This distinctive patient-oriented approach included four interlinked components, focusing on: • Establishing facilities and developing initiatives for the exploitation of cancer research in Europe, encouraging the development of evidence-based guidelines for good clinical practice and improved public health strategies by accelerating the translation of existing research results into applications. (1) http://www.europarl.europa.eu/sides/getDoc.do?pubRef=-//EP//NONSGML+TA+P6-TA-2008-0121+0+DOC+WORD+V0//EN (2) Adopted 10/06/08, www.consilium.europa.eu/Newsroom (3) http://www.uicc.org/wcd/wcd2008.pdf FOREWORD 7
Page 1 and 2: PROJECT SYNOPSES CANCER RESEARCH PR
Page 3 and 4: CANCER RESEARCH PROJECTS FUNDED UND
Page 5 and 6: TABLE OF CONTENTS FOREWORD - CANCER
Page 7: Prevention 97 EPIC 98 EUROCADET 100
Page 11 and 12: Biology Cancer is a disease ethat t
Page 13 and 14: p53 activators ASPP Partner 5 NFkap
Page 15 and 16: Keywords | Angiogenesis | vasculoge
Page 17 and 18: Keywords | Tumour-host interactions
Page 19 and 20: Keywords | Breast | metastasis | ge
Page 21 and 22: Keywords | Identifi cation of novel
Page 23 and 24: Keywords | Systems biology | modell
Page 25 and 26: Keywords | Oncology | anticancer th
Page 27 and 28: • public health research coupled
Page 29 and 30: Expected results We will construct
Page 31 and 32: Potential applications Our DNA is u
Page 33 and 34: Microscopic examination of tissue s
Page 35 and 36: Pluripotent embryonic stem cells ar
Page 37 and 38: • Decryption of the leukaemia cel
Page 39 and 40: • identifi cation of molecular ta
Page 41 and 42: A B C LT-HSC CSC The Cancer Stem Ce
Page 43 and 44: X-ray diff raction of target drug c
Page 45 and 46: using pathway-specifi c reporter ce
Page 47 and 48: Keywords | Kinases | pediatric panc
Page 49 and 50: Keywords | Lymphangiogenesis | angi
Page 51 and 52: Keywords | Breast cancer | metastas
Page 53 and 54: Keywords | Mitosis | phosphorylatio
Page 55 and 56: Keywords | Therapy | genome | telom
Page 57 and 58: Keywords | Multiple myeloma | cance
Page 59 and 60:
Keywords | p53 tumour suppressor |
Page 61 and 62:
Development of eff ective anti-canc
Page 63 and 64:
Coordinator Patrick A. Curmi INSERM
Page 65 and 66:
Drosophila as a model system for tu
Page 67 and 68:
Normal cell growth and epithelial l
Page 69 and 70:
effi ciently with cancer cell proli
Page 71 and 72:
A high-throughput assay of transcri
Page 73 and 74:
Coordinator Ewa Sikora Nencki Insti
Page 75 and 76:
Expected results The SIROCCO consor
Page 77 and 78:
Keywords | Epigenetics | gene regul
Page 79 and 80:
Keywords | Hereditary | tricarboxyl
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Keywords | HSV-1 | hepatocellular c
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Keywords | Apoptosis | autophagy |
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Keywords | Tumour | host | signalli
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Aetiology The uncontrolled cell gro
Page 89 and 90:
Coordinator Rosalind Eeles Reader i
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The parallelogram approach in CARCI
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Keywords | Melanoma | genetics | na
Page 95 and 96:
Keywords | Virus | bacteria | HPV |
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Keywords | Breast | prostate | gene
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Prevention The fact that preventing
Page 101 and 102:
Coordinator Elio Riboli Imperial Co
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Coordinator Jan Willem Coebergh Joh
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Coordinator Jose M a Benlloch Conse
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BAMOD Breath-Gas Analysis for Molec
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BioCare Molecular Imaging for Biolo
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These centres of excellence will in
Page 114 and 115:
Expected results Optimise the benef
Page 116 and 117:
114 Cell proliferation and apoptosi
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COBRED Colon and Breast cancer Diag
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DASIM Diagnostic Applications of Sy
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Expected results Primarily, the res
Page 124 and 125:
Coordinator John A. Foekens Dept. o
Page 126 and 127:
124 Aim Drop-Top has two major obje
Page 128 and 129:
Coordinator Gorka Ochoa Progenika B
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Expected results The E.E.T.-Pipelin
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e developed by eTUMOUR is likely to
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Coordinator Angel Porgador Ben-Guri
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• the design of a compact assembl
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Potential applications We believe t
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Tumor initiation, progression to ma
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MolDiag-Paca Novel Molecular Diagno
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NEMO Nano based capsule-Endoscopy w
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OVCAD Ovarian Cancer - Diagnosis of
Page 148 and 149:
P-MARK Validation of recently devel
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POC4life Multiparametric quantum do
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PROMET Prostate cancer molecular-or
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Micrometastasis in the bone marrow.
Page 156 and 157:
and pharmaco-kinetics studies. This
Page 158 and 159:
Coordinator Raffaella Giavazzi Isti
Page 160 and 161:
• Development of tools for diagno
Page 163 and 164:
Treatment Two major problems when t
Page 165 and 166:
Coordinator Lluis M. Mir UMR 8121 C
Page 167 and 168:
Potential applications ANGIOSTOP ha
Page 169 and 170:
Green-fl uorescence protein- expres
Page 171 and 172:
Coordinator Robert Hawkins Universi
Page 173 and 174:
Expected results The BACULOGENES pr
Page 175 and 176:
descriptors of the molecules to be
Page 177 and 178:
Keywords | Therapeutic vaccine | im
Page 179 and 180:
Keywords | Cancer chemotherapy | dr
Page 181 and 182:
Keywords | Children | cancer | leuk
Page 183 and 184:
Chimaeric TCR shown in context of n
Page 185 and 186:
Andrea Splendiani Leaf Bioscience s
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Coordinator Anne O’Garra The Medi
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Coordinator Jacques Bartholeyns IDM
Page 191 and 192:
Structure Driven Drug Design The in
Page 193 and 194:
• acquire fundamental knowledge a
Page 195 and 196:
Terry Jones Victoria University of
Page 197 and 198:
Potential applications The use of t
Page 199 and 200:
groups and management structures. T
Page 201 and 202:
T. Barbui Azienda Ospedaliera-Osped
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Keywords | Mantle cell lymphoma | t
Page 205 and 206:
Keywords | Hypoxia | HIF | pericell
Page 207 and 208:
Keywords | Radiation-induced compli
Page 209 and 210:
Keywords | Gene therapy | adenoviru
Page 211 and 212:
Keywords | Dependence receptors | a
Page 213 and 214:
Keywords | Photodynamic therapy | a
Page 215 and 216:
Keywords | Ovarian cancer | thymidy
Page 217 and 218:
Keywords | Quality assurance | clin
Page 219 and 220:
Keywords | Circadian | clocks | cel
Page 221 and 222:
Keywords | Anticancer therapy | onc
Page 223 and 224:
Coordinator Monika Lusky Transgene
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6 000 women over a three-year perio
Page 227 and 228:
Keywords | Solid tumours | apoptosi
Page 229 and 230:
Keywords | Lymphoma | leukaemia | v
Page 231:
Coordinator Riccardo Dolcetti Centr
Page 234 and 235:
CCPRB Cancer Control using Populati
Page 236 and 237:
EPCRC The European Palliative Care
Page 238 and 239:
EUROCAN+PLUS Feasibility Study for
Page 240 and 241:
EUSTIR A European strategy for the
Page 242 and 243:
NORMOLIFE Development of new therap
Page 245 and 246:
Scientifi c Model Systems The compl
Page 247 and 248:
Performance of benchmarking exercis
Page 249 and 250:
• markers correlating with the im
Page 251 and 252:
Indices - Keywords Indices - Partne
Page 253 and 254:
● disease markers 131 ● DNA dam
Page 255 and 256:
● renal 77 ● replication 219
Page 257 and 258:
Bos, Nico A. 56 Boskovic, Darinka 2
Page 259 and 260:
Geley, Stephan 159 Georgopoulos, Li
Page 261 and 262:
Lingner, Joachim 54 Linial, Michal
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Ragno, Pia 115 Rainford, Martyn 92
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Vernos, Isabelle 22 Veronesi, Umber
Page 267 and 268:
● Centre Hospitalier Universitair
Page 269 and 270:
● IFOM - Fondazione Istituto FIRC
Page 271 and 272:
● National University of Ireland
Page 273 and 274:
● University of Bari 174 ● Univ
Page 275 and 276:
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