Cancer Research - Europa

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SENECA From Cellular Senescence and Cell Death to Cancer and Ageing Summary The main objective of the SENECA project is to improve the awareness of ageing research among cancer researchers, stimulating cooperation between the two disciplines. To achieve this objective a conference will be organized to provide a forum for scientifi c exchange among leading scientists working in the fi elds of ageing and cancer, as well as to stimulate cooperation aimed at redefi ning molecular targets and improving cancer prevention and therapeutics in the ageing population. The discussion will focus on such issues as DNA damage, telomeres and telomerase in cancer and ageing, eff ects of tissue environment in tumour formation, impact of the ageing immune system on cancer immunosurveillance and immunotherapy, links between stem cells and cancer and ageing, links between tumour suppression and cellular senescence, and cellular senescence as a new target in anticancer therapy. Attendance of approx. 300 scientists and representatives of other key stakeholder groups from around the world is anticipated. Problem Age is the most important demographic risk factor for many life-threatening human cancers. Over two-thirds of all diagnosed cancers occur in people over the age of 65. According to IARC, worldwide cancer rates increase sharply with age: for the age group 65 years and older incidents of cancer are 2-3 times higher than in the 45-64 age group and 12-36 times higher than in the 25-44 age group. The increased incidence of cancer in elderly people has been related to age-associated changes occurring with time in the whole system. The elderly are more vulnerable than younger individuals to environmental carcinogens not only because of potentially greater exposure time, but for other reasons, including impaired macromolecular repair and defense against reactive oxygen species, age-dependent changes in tissue environment facilitating increased pro-infl ammatory status, possibly diminished immuno-surveillance of malignant transformation and pro-cancerogenic activity of senescent cells. Since tumours include cancer cells with an extensive proliferative history, subject to senescence and senescenceavoidance mechanisms, cancer researchers commonly study various aspects of biological ageing. However, many cancer specialists, clinicians, and industry representatives remain unaware of what ageing research can offer for cancer 70 Keywords | Cancer | ageing | cellular senescence | cell death | DNA damage | telomerase | immunosurveillance | prevention and therapy. Presently the research fi elds of biological ageing and cancer in Europe remain largely fragmented, without structured links or widespread interdisciplinary approaches. Aim The main goal of the project is to improve the awareness of ageing research among cancer researchers, stimulating cooperative research between the two disciplines. The enhanced cooperation should aim at redefi ning molecular targets and improving cancer prevention and therapeutics in the ageing population. This goal will be achieved by organizing an international conference for approximately 300 participants October 4-6, 2007. Expected results The conference will provide a forum for scientifi c exchange among outstanding European scientists working in the fi elds of ageing and cancer. The discussion will focus around such issues as: DNA damage, telomeres and telomerase in cancer and ageing, eff ects of tissue environment in tumour formation, impact of the ageing immune system on cancer immunosurveillance and immunotherapy, links between stem cells and cancer and ageing, links between tumour suppression and cellular senescence, and cellular senescence as a new target in anticancer therapy. The conference will also bring together other key stakeholder groups such as policy makers, clinicians and industry. The proposed event will contribute to attracting scientists from cancer research and other disciplines to ageing research. It will help to establish sustainable organizational links between these two closely related scientifi c fi elds, structuring European research in oncogerontology. Potential applications The planned conference is expected to: • stimulate cancer specialists to use the insights, results and methodologies stemming from ageing research in studying aetiology, prevention and therapy of cancer, especially in the elderly; • design strategies as to how basic research results in cancer and ageing can be best transferred into industrial exploitation and clinical practice. This may be an important starting point for the development of new preventive and therapeutic measures. It may give a whole new dimension to geriatric medicine, as it will shift the emphasis from care – which is extremely expensive – to maintenance of function and prevention of disease as long as possible. CANCER RESEARCH PROJECTS FUNDED UNDER THE SIXTH FRAMEWORK PROGRAMME
Coordinator Ewa Sikora Nencki Institute of Experimental Biology Polish Academy of Sciences (NENCKI) Warsaw, Poland e.sikora@nencki.gov.pl Partners Graham Pawelec University of Tübingen, Germany (TU) Vladimir Anisimov N.N. Petrov Research Institute of Oncology (PRIO) St. Petersburg, Russian Federation Project number LSSM-CT-2006-037312 EC contribution € 142 800 Duration 24 months Starting date 01/10/2006 Instrument SSA BIOLOGY 71
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PROJECT SYNOPSES CANCER RESEARCH PR
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CANCER RESEARCH PROJECTS FUNDED UND
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TABLE OF CONTENTS FOREWORD - CANCER
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Prevention 97 EPIC 98 EUROCADET 100
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CANCER: COMBATING A COMPLEX DISEASE
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Biology Cancer is a disease ethat t
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p53 activators ASPP Partner 5 NFkap
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Keywords | Angiogenesis | vasculoge
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Keywords | Tumour-host interactions
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Keywords | Breast | metastasis | ge
Page 21 and 22: Keywords | Identifi cation of novel
Page 23 and 24: Keywords | Systems biology | modell
Page 25 and 26: Keywords | Oncology | anticancer th
Page 27 and 28: • public health research coupled
Page 29 and 30: Expected results We will construct
Page 31 and 32: Potential applications Our DNA is u
Page 33 and 34: Microscopic examination of tissue s
Page 35 and 36: Pluripotent embryonic stem cells ar
Page 37 and 38: • Decryption of the leukaemia cel
Page 39 and 40: • identifi cation of molecular ta
Page 41 and 42: A B C LT-HSC CSC The Cancer Stem Ce
Page 43 and 44: X-ray diff raction of target drug c
Page 45 and 46: using pathway-specifi c reporter ce
Page 47 and 48: Keywords | Kinases | pediatric panc
Page 49 and 50: Keywords | Lymphangiogenesis | angi
Page 51 and 52: Keywords | Breast cancer | metastas
Page 53 and 54: Keywords | Mitosis | phosphorylatio
Page 55 and 56: Keywords | Therapy | genome | telom
Page 57 and 58: Keywords | Multiple myeloma | cance
Page 59 and 60: Keywords | p53 tumour suppressor |
Page 61 and 62: Development of eff ective anti-canc
Page 63 and 64: Coordinator Patrick A. Curmi INSERM
Page 65 and 66: Drosophila as a model system for tu
Page 67 and 68: Normal cell growth and epithelial l
Page 69 and 70: effi ciently with cancer cell proli
Page 71: A high-throughput assay of transcri
Page 75 and 76: Expected results The SIROCCO consor
Page 77 and 78: Keywords | Epigenetics | gene regul
Page 79 and 80: Keywords | Hereditary | tricarboxyl
Page 81 and 82: Keywords | HSV-1 | hepatocellular c
Page 83 and 84: Keywords | Apoptosis | autophagy |
Page 85 and 86: Keywords | Tumour | host | signalli
Page 87 and 88: Aetiology The uncontrolled cell gro
Page 89 and 90: Coordinator Rosalind Eeles Reader i
Page 91 and 92: The parallelogram approach in CARCI
Page 93 and 94: Keywords | Melanoma | genetics | na
Page 95 and 96: Keywords | Virus | bacteria | HPV |
Page 97 and 98: Keywords | Breast | prostate | gene
Page 99 and 100: Prevention The fact that preventing
Page 101 and 102: Coordinator Elio Riboli Imperial Co
Page 103 and 104: Coordinator Jan Willem Coebergh Joh
Page 105: Coordinator Jose M a Benlloch Conse
Page 108 and 109: BAMOD Breath-Gas Analysis for Molec
Page 110 and 111: BioCare Molecular Imaging for Biolo
Page 112 and 113: These centres of excellence will in
Page 114 and 115: Expected results Optimise the benef
Page 116 and 117: 114 Cell proliferation and apoptosi
Page 118 and 119: COBRED Colon and Breast cancer Diag
Page 120 and 121: DASIM Diagnostic Applications of Sy
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Expected results Primarily, the res
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Coordinator John A. Foekens Dept. o
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124 Aim Drop-Top has two major obje
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Coordinator Gorka Ochoa Progenika B
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Expected results The E.E.T.-Pipelin
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e developed by eTUMOUR is likely to
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Coordinator Angel Porgador Ben-Guri
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• the design of a compact assembl
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Potential applications We believe t
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Tumor initiation, progression to ma
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MolDiag-Paca Novel Molecular Diagno
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NEMO Nano based capsule-Endoscopy w
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OVCAD Ovarian Cancer - Diagnosis of
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P-MARK Validation of recently devel
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POC4life Multiparametric quantum do
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PROMET Prostate cancer molecular-or
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Micrometastasis in the bone marrow.
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and pharmaco-kinetics studies. This
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Coordinator Raffaella Giavazzi Isti
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• Development of tools for diagno
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Treatment Two major problems when t
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Coordinator Lluis M. Mir UMR 8121 C
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Potential applications ANGIOSTOP ha
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Green-fl uorescence protein- expres
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Coordinator Robert Hawkins Universi
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Expected results The BACULOGENES pr
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descriptors of the molecules to be
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Keywords | Therapeutic vaccine | im
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Keywords | Cancer chemotherapy | dr
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Keywords | Children | cancer | leuk
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Chimaeric TCR shown in context of n
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Andrea Splendiani Leaf Bioscience s
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Coordinator Anne O’Garra The Medi
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Coordinator Jacques Bartholeyns IDM
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Structure Driven Drug Design The in
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• acquire fundamental knowledge a
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Terry Jones Victoria University of
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Potential applications The use of t
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groups and management structures. T
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T. Barbui Azienda Ospedaliera-Osped
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Keywords | Mantle cell lymphoma | t
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Keywords | Hypoxia | HIF | pericell
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Keywords | Radiation-induced compli
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Keywords | Gene therapy | adenoviru
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Keywords | Dependence receptors | a
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Keywords | Photodynamic therapy | a
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Keywords | Ovarian cancer | thymidy
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Keywords | Quality assurance | clin
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Keywords | Circadian | clocks | cel
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Keywords | Anticancer therapy | onc
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Coordinator Monika Lusky Transgene
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6 000 women over a three-year perio
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Keywords | Solid tumours | apoptosi
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Keywords | Lymphoma | leukaemia | v
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Coordinator Riccardo Dolcetti Centr
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CCPRB Cancer Control using Populati
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EPCRC The European Palliative Care
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EUROCAN+PLUS Feasibility Study for
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EUSTIR A European strategy for the
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NORMOLIFE Development of new therap
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Scientifi c Model Systems The compl
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Performance of benchmarking exercis
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• markers correlating with the im
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Indices - Keywords Indices - Partne
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● disease markers 131 ● DNA dam
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● renal 77 ● replication 219
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Bos, Nico A. 56 Boskovic, Darinka 2
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Geley, Stephan 159 Georgopoulos, Li
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Lingner, Joachim 54 Linial, Michal
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Ragno, Pia 115 Rainford, Martyn 92
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Vernos, Isabelle 22 Veronesi, Umber
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● Centre Hospitalier Universitair
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● IFOM - Fondazione Istituto FIRC
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● National University of Ireland
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● University of Bari 174 ● Univ
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HOW TO OBTAIN EU PUBLICATIONS Our p
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