Cancer Research - Europa

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4 TABLE OF CONTENTS Biology 9 Active p53 10 ANGIOTARGETING 1 3 Anti-tumour targeting 1 5 BRECOSM 1 7 CAPPELLA 19 COMBIO 2 1 CONTICANET 23 DIAMONDS 26 DNA Repair 28 ENLIGHT 30 EPISTEM 32 EPITRON 34 EuroBoNeT 36 EuroCSC 38 GROWTHSTOP 40 INTACT 42 KidsCancerKinome 45 Lymphangiogenomics 47 MetaBre 49 MitoCheck 5 1 MOL CANCER MED 53 MSCNET 55 Mutp53 57 Nano4Drugs 60 ONCASYM 62 ONCODEATH 64 PRIMA 66 Regulatory Genomics 68 SENECA 70 SIROCCO 72 SMARTER 75 TCAC in Cancer 77 THOVLEN 79 TransDeath 8 1 TRKCancer 82 Tumour-Host Genomics 83 Aetiology 85 AIDIT 86 CARCINOGENOMICS 88 GenoMEL 91 INCA 93 POLYGENE 95 CANCER RESEARCH PROJECTS FUNDED UNDER THE SIXTH FRAMEWORK PROGRAMME
Prevention 97 EPIC 98 EUROCADET 100 MAMMI 102 Early Detection, Diagnosis and Prognosis 105 BAMOD 106 BioCare 108 BMC 1 1 1 CANCERDEGRADOME 1 1 3 COBRED 1 1 6 DASIM 1 1 8 DISMAL 1 1 9 DNA METHYLATION 1 2 1 Drop-Top 123 E.E.T.-Pipeline 127 eTUMOUR 129 GLYFDIS 1 3 1 HI-CAM 133 HighReX 135 MCSCs 137 MMR-related cancer 139 MolDiag-Paca 140 NEMO 142 OVCAD 144 P-MARK 146 POC4life 148 PROMET 150 PROTHETS 153 STROMA 155 TRANSFOG 157 Treatment 161 ANGIOSKIN 162 ANGIOSTOP 164 Apotherapy 166 ATTACK 168 BACULOGENES 170 CancerGrid 1 7 2 CANCERIMMUNOTHERAPY 1 7 5 CHEMORES 1 7 7 CHILDHOPE 1 7 9 DC-THERA 182 DC-VACC 1 8 4 Dendritophages 186 DEPPICT 188 TABLE OF CONTENTS 5
Page 1 and 2: PROJECT SYNOPSES CANCER RESEARCH PR
Page 3 and 4: CANCER RESEARCH PROJECTS FUNDED UND
Page 5: TABLE OF CONTENTS FOREWORD - CANCER
Page 9 and 10: CANCER: COMBATING A COMPLEX DISEASE
Page 11 and 12: Biology Cancer is a disease ethat t
Page 13 and 14: p53 activators ASPP Partner 5 NFkap
Page 15 and 16: Keywords | Angiogenesis | vasculoge
Page 17 and 18: Keywords | Tumour-host interactions
Page 19 and 20: Keywords | Breast | metastasis | ge
Page 21 and 22: Keywords | Identifi cation of novel
Page 23 and 24: Keywords | Systems biology | modell
Page 25 and 26: Keywords | Oncology | anticancer th
Page 27 and 28: • public health research coupled
Page 29 and 30: Expected results We will construct
Page 31 and 32: Potential applications Our DNA is u
Page 33 and 34: Microscopic examination of tissue s
Page 35 and 36: Pluripotent embryonic stem cells ar
Page 37 and 38: • Decryption of the leukaemia cel
Page 39 and 40: • identifi cation of molecular ta
Page 41 and 42: A B C LT-HSC CSC The Cancer Stem Ce
Page 43 and 44: X-ray diff raction of target drug c
Page 45 and 46: using pathway-specifi c reporter ce
Page 47 and 48: Keywords | Kinases | pediatric panc
Page 49 and 50: Keywords | Lymphangiogenesis | angi
Page 51 and 52: Keywords | Breast cancer | metastas
Page 53 and 54: Keywords | Mitosis | phosphorylatio
Page 55 and 56: Keywords | Therapy | genome | telom
Page 57 and 58:
Keywords | Multiple myeloma | cance
Page 59 and 60:
Keywords | p53 tumour suppressor |
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Development of eff ective anti-canc
Page 63 and 64:
Coordinator Patrick A. Curmi INSERM
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Drosophila as a model system for tu
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Normal cell growth and epithelial l
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effi ciently with cancer cell proli
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A high-throughput assay of transcri
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Coordinator Ewa Sikora Nencki Insti
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Expected results The SIROCCO consor
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Keywords | Epigenetics | gene regul
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Keywords | Hereditary | tricarboxyl
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Keywords | HSV-1 | hepatocellular c
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Keywords | Apoptosis | autophagy |
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Keywords | Tumour | host | signalli
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Aetiology The uncontrolled cell gro
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Coordinator Rosalind Eeles Reader i
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The parallelogram approach in CARCI
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Keywords | Melanoma | genetics | na
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Keywords | Virus | bacteria | HPV |
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Keywords | Breast | prostate | gene
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Prevention The fact that preventing
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Coordinator Elio Riboli Imperial Co
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Coordinator Jan Willem Coebergh Joh
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Coordinator Jose M a Benlloch Conse
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BAMOD Breath-Gas Analysis for Molec
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BioCare Molecular Imaging for Biolo
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These centres of excellence will in
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Expected results Optimise the benef
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114 Cell proliferation and apoptosi
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COBRED Colon and Breast cancer Diag
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DASIM Diagnostic Applications of Sy
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Expected results Primarily, the res
Page 124 and 125:
Coordinator John A. Foekens Dept. o
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124 Aim Drop-Top has two major obje
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Coordinator Gorka Ochoa Progenika B
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Expected results The E.E.T.-Pipelin
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e developed by eTUMOUR is likely to
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Coordinator Angel Porgador Ben-Guri
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• the design of a compact assembl
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Potential applications We believe t
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Tumor initiation, progression to ma
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MolDiag-Paca Novel Molecular Diagno
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NEMO Nano based capsule-Endoscopy w
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OVCAD Ovarian Cancer - Diagnosis of
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P-MARK Validation of recently devel
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POC4life Multiparametric quantum do
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PROMET Prostate cancer molecular-or
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Micrometastasis in the bone marrow.
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and pharmaco-kinetics studies. This
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Coordinator Raffaella Giavazzi Isti
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• Development of tools for diagno
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Treatment Two major problems when t
Page 165 and 166:
Coordinator Lluis M. Mir UMR 8121 C
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Potential applications ANGIOSTOP ha
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Green-fl uorescence protein- expres
Page 171 and 172:
Coordinator Robert Hawkins Universi
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Expected results The BACULOGENES pr
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descriptors of the molecules to be
Page 177 and 178:
Keywords | Therapeutic vaccine | im
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Keywords | Cancer chemotherapy | dr
Page 181 and 182:
Keywords | Children | cancer | leuk
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Chimaeric TCR shown in context of n
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Andrea Splendiani Leaf Bioscience s
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Coordinator Anne O’Garra The Medi
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Coordinator Jacques Bartholeyns IDM
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Structure Driven Drug Design The in
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• acquire fundamental knowledge a
Page 195 and 196:
Terry Jones Victoria University of
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Potential applications The use of t
Page 199 and 200:
groups and management structures. T
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T. Barbui Azienda Ospedaliera-Osped
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Keywords | Mantle cell lymphoma | t
Page 205 and 206:
Keywords | Hypoxia | HIF | pericell
Page 207 and 208:
Keywords | Radiation-induced compli
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Keywords | Gene therapy | adenoviru
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Keywords | Dependence receptors | a
Page 213 and 214:
Keywords | Photodynamic therapy | a
Page 215 and 216:
Keywords | Ovarian cancer | thymidy
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Keywords | Quality assurance | clin
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Keywords | Circadian | clocks | cel
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Keywords | Anticancer therapy | onc
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Coordinator Monika Lusky Transgene
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6 000 women over a three-year perio
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Keywords | Solid tumours | apoptosi
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Keywords | Lymphoma | leukaemia | v
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Coordinator Riccardo Dolcetti Centr
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CCPRB Cancer Control using Populati
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EPCRC The European Palliative Care
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EUROCAN+PLUS Feasibility Study for
Page 240 and 241:
EUSTIR A European strategy for the
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NORMOLIFE Development of new therap
Page 245 and 246:
Scientifi c Model Systems The compl
Page 247 and 248:
Performance of benchmarking exercis
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• markers correlating with the im
Page 251 and 252:
Indices - Keywords Indices - Partne
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● disease markers 131 ● DNA dam
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● renal 77 ● replication 219
Page 257 and 258:
Bos, Nico A. 56 Boskovic, Darinka 2
Page 259 and 260:
Geley, Stephan 159 Georgopoulos, Li
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Lingner, Joachim 54 Linial, Michal
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Ragno, Pia 115 Rainford, Martyn 92
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Vernos, Isabelle 22 Veronesi, Umber
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● Centre Hospitalier Universitair
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● IFOM - Fondazione Istituto FIRC
Page 271 and 272:
● National University of Ireland
Page 273 and 274:
● University of Bari 174 ● Univ
Page 275 and 276:
HOW TO OBTAIN EU PUBLICATIONS Our p
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