Cancer Research - Europa

Keywords | Lymphangiogenesis | angiogenesis | gene therapy | infl ammatory diseases |
lymphedema | tissue ischemia |
Lymphangiogenomics
Genome-wide Discovery
and Functional Analysis of Novel Genes
in Lymphangiogenesis
Summary
Lymphangiogenomics is an Integrated Project with 14 participating
consortium members. Its aim is to dissect the
processes of lymphangiogenesis thoroughly and to compare
them with angiogenesis at the genetic, molecular,
cellular and functional levels.
Aim
The aim of this project is to discover novel genes important
for lymphatic vascular versus blood vascular development
and function, and to study the functional role and therapeutic
potential of their gene products in lymphangiogenesis
using state-of-the-art technologies.
Expected results
These studies will provide a new and fundamental understanding
of the molecular and cellular basis of lymphangiogenesis
and therefore enable scientists to develop therapies to suppress
the growth of lymphatic vessels (for example for cancer
and infl ammatory diseases) or to stimulate their growth (for
example for tissue ischemia and lymphedema).
Lymphangiogenomics puts forward ambitious and competitive
research objectives addressing biological processes of
high medical importance using a multidisciplinary analysis and
validation approach.
Potential applications
Novel therapies for cancer, infl ammatory diseases, lymphedema
and tissue ischemia.
BIOLOGY
Lymphatic vessels in a whole mount preparation of the mouse ear skin are visualised with
antibodies to LYVE-1 (green). Blood vessels are stained with PECAM-1 antibodies (red).
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