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X-ray diff raction of target drug complexes at high resolution.<br />
More specifi cally, the following aims will be addressed:<br />
• advanced cancer mouse models, hepatocellular carcinoma<br />
and squamous cell carcinoma (SCC) will be used<br />
to dissect the contribution of individual kinase pathways<br />
to the survival of tumour cells;<br />
• understanding of the signalling mechanisms used by<br />
human tumours to counteract apoptosis will be improved;<br />
• a lucid and structured pathway to exploit these fi ndings<br />
for therapeutic intervention will be provided, by addressing<br />
the problems that hinder the effi cient translation of<br />
knowledge about kinase pathways into therapeutic<br />
approaches.<br />
Expected results<br />
Through the integrated approach of the project, the following<br />
results are expected:<br />
• an understanding of the pathways that signal apoptosis<br />
in solid tumours;<br />
• their validation as viable targets for tumour suppression<br />
or regression in animal models in vivo;<br />
• and the discovery and validation of a novel, alternative<br />
class of inhibitors that specifi cally targets protein interactions<br />
rather than, or in addition to, enzyme activity, with<br />
the fi nal goal of establishing the manipulation of apoptotic<br />
pathways as a viable strategy for cancer therapy.<br />
Potential applications<br />
Proliferative diseases.<br />
Coordinator<br />
Lukas Huber<br />
Innsbruck Medical University<br />
Innsbruck, Austria<br />
lukas.a.huber@i-med.ac.at<br />
Partners<br />
Manuela Baccarini<br />
University of Vienna<br />
Vienna, Austria<br />
Martin Eilers<br />
Philipps University of Marburg<br />
Marburg, Germany<br />
Maria Sibilia<br />
Medical University of Vienna<br />
Vienna, Austria<br />
Rony Seger<br />
Weizmann Institute of Science<br />
Rehovot, Israel<br />
Tony Ng<br />
King’s College London<br />
London, United Kingdom<br />
Project number<br />
LSHC-CT-2006-037731<br />
EC contribution<br />
€ 3 531 507<br />
Duration<br />
48 months<br />
Starting date<br />
01/10/2006<br />
Instrument<br />
STREP<br />
Project website<br />
www.cemit.at/<br />
growthstop<br />
Piero Crespo Baraja<br />
Consejo Superior de<br />
Investigaciones Cientificas<br />
Santander, Spain<br />
Walter Kolch<br />
Beatson Institute<br />
for <strong>Cancer</strong> <strong>Research</strong><br />
Glasgow, United Kingdom<br />
György Kéri<br />
Vichem Chemie <strong>Research</strong> Ltd.<br />
Budapest, Hungary<br />
Martin Ried<br />
CRELUX GmbH<br />
Munich, Germany<br />
Armin Peter Czernilofsky<br />
Baden, Austria<br />
Blair Henderson<br />
Center of Excellence in Medicine & IT GmBh<br />
Innsbruck, Austria<br />
BIOLOGY<br />
41
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