Myklebost, Ola 37 Myllykallio, Hannu 214 Naafs-Wilstra, Marianne C. 181 Naldini, Luigi 84 Nasioulas, Georgios 65 Naume, Björn 120 Naumova, Elissaveta 195 Navarro, Carmen 99 Naylor, Stuart 204 Neal, David 67 Neidle, Stephen 54 Neoptolemos, John 141 Neri, Dario 156, 212 Nerlov, Claus 39 Neubauer, A. 199 Neuhaus, Eckhardt 141 Neumann, Hartmut P.H. 78 Newbold, Robert 54 Newell, Herbie 189 Newton Bishop, Julia A. 92 Ng, Tony 41 Niclou, Simone 14 Nicol, Keith 54 Nicolaï, Jean-Philippe 216 Nicolette, Charles 183 Niederhauser, Joel J. 152 Niederwieser, D. 198 Nielsen, Peter Egil 192 Niklas, Zojer 56 Nilsson, Olle 147, 149 Nilsson, Sten 59 Noël, Agnès 18 Nolli, Maria Luisa 229 Norberg, Gunnar 110 Normark, Staffan 94 Novak, Bela 22 O’Brien, S. 198 O’Dwyer, M. 198 O’Garra, Anne 182, 185 O’Kelly, Paddy 120 O’Sullivan, Gerald 25 Ochoa, Gorka 126 Ögmundsdóttir, Helga M. 233 Ogur, Gönül 200 Ojala, Paivi 94 Olaiz, Javier 25 Olko, Pavel 216 Ollivier, Sophie 189 260 Olsson, Håkan 92 Oren, Moshe 12, 59 Orfao, A. 199 Orfao, Alberto 56 Ørntoft, Torben 69 Oscier, D. 199 Ossenkoppele, G. 198 Ott, German 202 Oultram, John 141 Overvad, Kim 99 Ozbek, U. 200 P. Ryan, Michael 90 Pagani, Olivia 224 Palecek, Emil 59 Palli, Domenico 99 Panayotou, George 159 Pane, F. 199 Panes, Juliàn 193 Panico, Salvatore 99 Pantel, Klaus 120 Panzner, Steffen 167 Papon, Eric 25 Paridaens, Robert 115 Parker, David 192 Parkinson, Kenneth 54 Parwaresch, Reza 202 Passalacqua, Rodolfo 223 Passioukov, Alexandre 178 Pastorekova, Silvia 204 Patient, Roger 39 Pawelec, Graham 71, 195 Pawlita, Michael 94 Pedley, Barbara 156 Pedone, Carlo 192 Peeper, Daniel 82 Peeters, Petra 99 Pelicci, Pier Giuseppe 44 Pellicciari, Roberto 189 Perbal, Bernard 154 Permert, Johan 141 Peter-Katalinic, Jasna 132 Peters, Christoph 115 Peters, Jan-Michael 52 Peters, Joop A. 192 Petersen, Ole W. 39 Peterson, Curt 178 Petralia, Filippo 183 Petrus, Hans 229 Petruzelka, Lubos 223 Pettersen, Erik 204 Pettersson, Kim S. 147 Piccart, Martine 223 Picci, Piero 37, 154 Pieri, Philippe 149 Pierotti, Marco 159, 178 Pierre, Philippe 183 Pietsch, Torsten 46 Pihlajaniemi, Taina 14 Pinedo, Herbert Michael 237 Pintzas, Alexander 65 Piotto, Martial 130 Pirovano, Marco 218 Pisa, Pavel 183 Pisani, Paola 101 Plevani, Paolo 29 Plumas, Joël 181 Poellinger, Lorenz 204 Pohlenz, Hans-Dieter 141 Pongsak, Angkasith 33 Popov, Zivko 126 Poremba, Chris 37 Porgador, Angel 132 Post, Claes 59 Pott, Christiane 202 Poustka, Annemarie 159, 245 Préat, Véronique 163 Preisegger, Karl-Heinz 16 Preudhomme, C. 199 Price, Patricia 110 Prince, Miles 187 Prix, Lothar 145 Probst, Jochen 176 Protti, Maria Pia 183 Puig Sarda, Susana 92 Pukkala, Eero 101 Pule, Martin 181 Pyerin, Walter 152 Quax, Wim 226 Questier, Benjamin 112 Raap, Anton 31 Rabinovitz, Elisha 143 Radbruch, Andreas 183 Radbruch, Lukas 235 Rademacher, Bernd 193 Rademann, Jörg 141 Radvanyi, Francois 126 CANCER RESEARCH PROJECTS FUNDED UNDER THE SIXTH FRAMEWORK PROGRAMME
Ragno, Pia 115 Rainford, Martyn 92 Rammensee, Hans-Georg 176 Ranghetti, Anna 185 Rasmussen, Lene Juel 139 Ratcliffe, Peter 204 Raymond, Alan 208 Real, Francisco X. 141 Rees, Robert 195 Reichert, Bas 248 Reilly, J. 199 Reimann-Zawadzki, Meike 143 Reis e Sousa, Caetano 183 Reiter, Yoram 169 Reske, Sven 141 Ribera, J. 199 Riboli, Elio 99 Ribrag, Vincent 202 Ricciardi Castagnoli, Paola 183, 185 Richter, Wiltrud 37 Ridley, Anne 159 Ried, Martin 41 Riegman, Peter 37 Ringborg, Ulrik 237 Ringwald, Annette 94 Rio, Marie-Christine 115 Robak, T. 199 Robert, Caroline 163 Robertson, Graeme 189 Robine, Sylvie 65 Robles, Montserrat 130 Robson, Craig 67 Rocchi, M. 199 Rocha, Benedita 183 Roesch, Frank 192 Roggen, Erwin 90 Rogiers, Vera 90 Roman, E. 200 Romeo, Giovanni 210 Romero, Pedro 176 Ronsisvalle, Giuseppe 241 Roos, Goran 54 Rosato, Antonio 229 Rosenberg, Ivan 192 Rosenfeld, Rakefet 132 Rosenwald, Andreas 202 Rossi, Carlo Ricardo 25 Rossig, Claudia 181 INDICES Rotter, Varda 12, 59, 67 Rousseau, Raphaël F. 181 Rowe, J. 198 Rubinstein, Avraham 143 Rudd, Pauline 132 Ruiz i Altaba, Ariel 20 Russo, Vincenzo 176 Ruutu, T. 198 Saarma, Mart 174 Sacchi, Ada 59 Saghatchian-d’Assignies, Mahasti 223 Saglio, G. 198 Sahin, Ugur 176 Sahota, Surinder S. 56 Salles, Gilles 202 Sallusto, Federica 183 Salvat, Francesc 216 Salven, Petri 84 Samali, Afshin 226 Sambani, C. 200 Samonigg, Hellmut 235 Sandro, Onori 216 Sansone, Susanna-Assunta 90 Santos, Andrès 193 Sanz, Ferran 174 Sanz, M. 198 Sastre-Garau, Xavier 117 Sauerwein, Wolfgang 216 Sauter, Guido 115 Savchenko, V. 198 Savva, N. 200 Scarpa, Aldo 141 Schadendorf, Dirk 92, 176, 195 Schaftenaar, Gijs 33 Schalken, J. A. 67 Schalken, Jack 147 Schaude, Michael 235 Schauser, Leif 96 Scheffold, Alexander 183 Schiewe, Hajo 20 Schild, Hansjoerg 176 Schlag, Peter 18 Schlegelberger, Brigitte 202 Schmitt, Clemens 44 Schmitt, Fernando 224 Schmitt, Manfred 122 Schmitt, Manfred 178 Schmitt-Gräff, A. 199 Schmitt-Verhulst, Anne-Marie 176 Schneider, Claudio 159 Schöffski, Patrick 25 Schön, Michael P. 163 Schouten, Jan 37 Schroeder, Olaf 241 Schubert, Jochen 107 Schuebeler, Dirk 76 Schueler, Julia 82 Schuetz, Andreas 145 Schuler, Gerold 176, 182, 185 Schulz, Thomas F. 94 Schumacher, Ton 169 Schwab, Manfred 128 Schwabe, Nikolai 229 Sciot, Raf 37 Scozzafava, Andea 204 Sedman, Juhan 20 Segebarth, Christoph 130 Seger, Rony 41 Sehouli, Jalid 145 Selivanova, Galina 12, 59 Séradour, Brigitte 136 Serakinci, Nedime 54 Serra, Massimo 46 Serrano, Luis 22, 226 Serrano, Manuel 44 Seruca, Raquel 139 Seymour, Leonard 208 Shacked, Zippora 59 Shamir, Ron 245 Sharp, Linda 141 Sheng-Wu, Xie 33 Shipley, Janet 46 Sibilia, Maria 41 Sicard, Hélène 176 Siebert, Reiner 202 Sieckmann, Frank 52 Sierra, Angels 50 Sierra, J. 198 Sikora, Ewa 71 Simonsson, B. 198 Sivard, Ake 143 Sixt, Bernhard 44, 120, 159 Skotnicki, A. 198 Skov, Lone 163 Sleeman, Jonathan 18 Slegers, Guido 115 261
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PROJECT SYNOPSES CANCER RESEARCH PR
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CANCER RESEARCH PROJECTS FUNDED UND
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TABLE OF CONTENTS FOREWORD - CANCER
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Prevention 97 EPIC 98 EUROCADET 100
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CANCER: COMBATING A COMPLEX DISEASE
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Biology Cancer is a disease ethat t
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p53 activators ASPP Partner 5 NFkap
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Keywords | Angiogenesis | vasculoge
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Keywords | Tumour-host interactions
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Keywords | Breast | metastasis | ge
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Keywords | Identifi cation of novel
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Keywords | Systems biology | modell
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Keywords | Oncology | anticancer th
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• public health research coupled
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Expected results We will construct
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Potential applications Our DNA is u
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Microscopic examination of tissue s
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Pluripotent embryonic stem cells ar
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• Decryption of the leukaemia cel
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• identifi cation of molecular ta
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A B C LT-HSC CSC The Cancer Stem Ce
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X-ray diff raction of target drug c
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using pathway-specifi c reporter ce
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Keywords | Kinases | pediatric panc
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Keywords | Lymphangiogenesis | angi
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Keywords | Breast cancer | metastas
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Keywords | Mitosis | phosphorylatio
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Keywords | Therapy | genome | telom
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Keywords | Multiple myeloma | cance
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Keywords | p53 tumour suppressor |
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Development of eff ective anti-canc
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Coordinator Patrick A. Curmi INSERM
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Drosophila as a model system for tu
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Normal cell growth and epithelial l
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effi ciently with cancer cell proli
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A high-throughput assay of transcri
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Coordinator Ewa Sikora Nencki Insti
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Expected results The SIROCCO consor
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Keywords | Epigenetics | gene regul
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Keywords | Hereditary | tricarboxyl
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Keywords | HSV-1 | hepatocellular c
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Keywords | Apoptosis | autophagy |
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Keywords | Tumour | host | signalli
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Aetiology The uncontrolled cell gro
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Coordinator Rosalind Eeles Reader i
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The parallelogram approach in CARCI
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Keywords | Melanoma | genetics | na
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Keywords | Virus | bacteria | HPV |
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Keywords | Breast | prostate | gene
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Prevention The fact that preventing
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Coordinator Elio Riboli Imperial Co
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Coordinator Jan Willem Coebergh Joh
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Coordinator Jose M a Benlloch Conse
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BAMOD Breath-Gas Analysis for Molec
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BioCare Molecular Imaging for Biolo
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These centres of excellence will in
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Expected results Optimise the benef
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114 Cell proliferation and apoptosi
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COBRED Colon and Breast cancer Diag
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DASIM Diagnostic Applications of Sy
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Expected results Primarily, the res
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Coordinator John A. Foekens Dept. o
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124 Aim Drop-Top has two major obje
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Coordinator Gorka Ochoa Progenika B
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Expected results The E.E.T.-Pipelin
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e developed by eTUMOUR is likely to
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Coordinator Angel Porgador Ben-Guri
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• the design of a compact assembl
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Potential applications We believe t
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Tumor initiation, progression to ma
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MolDiag-Paca Novel Molecular Diagno
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NEMO Nano based capsule-Endoscopy w
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OVCAD Ovarian Cancer - Diagnosis of
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P-MARK Validation of recently devel
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POC4life Multiparametric quantum do
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PROMET Prostate cancer molecular-or
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Micrometastasis in the bone marrow.
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and pharmaco-kinetics studies. This
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Coordinator Raffaella Giavazzi Isti
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• Development of tools for diagno
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Treatment Two major problems when t
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Coordinator Lluis M. Mir UMR 8121 C
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Potential applications ANGIOSTOP ha
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Green-fl uorescence protein- expres
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Coordinator Robert Hawkins Universi
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Expected results The BACULOGENES pr
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descriptors of the molecules to be
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Keywords | Therapeutic vaccine | im
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Keywords | Cancer chemotherapy | dr
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Keywords | Children | cancer | leuk
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Chimaeric TCR shown in context of n
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Andrea Splendiani Leaf Bioscience s
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Coordinator Anne O’Garra The Medi
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Coordinator Jacques Bartholeyns IDM
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Structure Driven Drug Design The in
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• acquire fundamental knowledge a
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Terry Jones Victoria University of
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Potential applications The use of t
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groups and management structures. T
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T. Barbui Azienda Ospedaliera-Osped
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Keywords | Mantle cell lymphoma | t
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Keywords | Hypoxia | HIF | pericell
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Keywords | Radiation-induced compli
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Keywords | Gene therapy | adenoviru
- Page 211 and 212: Keywords | Dependence receptors | a
- Page 213 and 214: Keywords | Photodynamic therapy | a
- Page 215 and 216: Keywords | Ovarian cancer | thymidy
- Page 217 and 218: Keywords | Quality assurance | clin
- Page 219 and 220: Keywords | Circadian | clocks | cel
- Page 221 and 222: Keywords | Anticancer therapy | onc
- Page 223 and 224: Coordinator Monika Lusky Transgene
- Page 225 and 226: 6 000 women over a three-year perio
- Page 227 and 228: Keywords | Solid tumours | apoptosi
- Page 229 and 230: Keywords | Lymphoma | leukaemia | v
- Page 231: Coordinator Riccardo Dolcetti Centr
- Page 234 and 235: CCPRB Cancer Control using Populati
- Page 236 and 237: EPCRC The European Palliative Care
- Page 238 and 239: EUROCAN+PLUS Feasibility Study for
- Page 240 and 241: EUSTIR A European strategy for the
- Page 242 and 243: NORMOLIFE Development of new therap
- Page 245 and 246: Scientifi c Model Systems The compl
- Page 247 and 248: Performance of benchmarking exercis
- Page 249 and 250: • markers correlating with the im
- Page 251 and 252: Indices - Keywords Indices - Partne
- Page 253 and 254: ● disease markers 131 ● DNA dam
- Page 255 and 256: ● renal 77 ● replication 219
- Page 257 and 258: Bos, Nico A. 56 Boskovic, Darinka 2
- Page 259 and 260: Geley, Stephan 159 Georgopoulos, Li
- Page 261: Lingner, Joachim 54 Linial, Michal
- Page 265 and 266: Vernos, Isabelle 22 Veronesi, Umber
- Page 267 and 268: ● Centre Hospitalier Universitair
- Page 269 and 270: ● IFOM - Fondazione Istituto FIRC
- Page 271 and 272: ● National University of Ireland
- Page 273 and 274: ● University of Bari 174 ● Univ
- Page 275 and 276: HOW TO OBTAIN EU PUBLICATIONS Our p