Cancer Research - Europa

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Coordinator Isabelle Vernos Centre for Genomic Regulation (CRG) Barcelona, Spain isabelle.vernos@crg.es Partners Francois Nedelec European Molecular Biology Laboratory (EMBL) Cell Biology and Biophysics Unit Heidelberg, Germany Olga Kel-Margoulis Edgar Wingender BIOBASE Pathway Databases Wolfenbüttel, Germany Uri Alon Weizmann Institute of Science Dept. of Molecular Cell Biology Rehovot, Israel Marcelle Kaufman Université Libre de Bruxelles Centre for Nonlinear Phenomena and Complex Systems, Brussels, Belgium 22 Edgar Wingender University of Göttingen Dept. of Bioinformatics Göttingen, Germany Béla Novák Technical University of Budapest Molecular Network Dynamics Research Group Budapest, Hungary Alfonso Valencia National Centre for Biotechnology Protein Design Group Madrid, Spain Cayetano Gonzales Parc cientific de Barcelona Cell Division Laboratory Barcelona, Spain Luis Serrano Systems Biology Research Unit Barcelona, Spain luis.serrano@crg.es Project number LSHG-CT-2004-503568 EC contribution € 1 998 000 Duration 42 months Starting date 01/03/2004 Instrument STREP Project website www.pdg.cnb.uam.es/ COMBIO/ CANCER RESEARCH PROJECTS FUNDED UNDER THE SIXTH FRAMEWORK PROGRAMME
Keywords | Oncology | anticancer therapy | clinical pharmacology | uncommon cancer | sarcomas | GIST | children | adults | CONTICANET Connective Tissue Cancers’ Network to integrate the European Experience in Adults and Children Summary Connective tissue cancers, and more specifically sarcomas, GIST, aggressive fibromatosis and hamartomas, are uncommon cancers with an incidence below 2/100 000 per year in the EU aff ecting children, young adults and adults. At a national level, the limited number of cases (about 7/10 000 in Europe each year) does not allow Europe to have a critical mass of researchers and the supporting environment to progress in the disease understanding and management and to have access to new drugs and treatments. Europe, however, has proven with research made on GIST, through the EORTC-STBSG group, that gathering workforces can achieve significant progress. CONTICANET will create the critical mass of key stakeholders to overcome the current difficulties in terms of lack of data and data fragmentation, mobility of researchers, heterogeneity of methodologies and legislations. CONTICANET will: • start by providing the required environment for developing joint research activities through the development of standard operating procedures (SOP), distributed databases, tissue banks and harmonisation of ongoing and previous research projects, to promote complementarity and perform parallel research programmes according to similar SOPs; • provide the infrastructure to test several drug candidates and perform European wide exploratory clinical trials while implementing a federated research policy; • further lead to an integrated sustainable structure – a European research foundation – able to support integrated research actions and make new treatments available. Involving 20 partners – major comprehensive cancer centres, academia and private companies – over a period of five years, CONTICANET will gather the critical mass of resources and knowledge in the understanding, diagnosis and clinical management of connective tissue cancers, at the same time opening new therapeutic options. CONTICANET will spread excellence in several directions: enlarging the network with other academic and private organisations; developing working sessions with EMEA, health authorities and insurances in order to optimise the availability of new therapeutic options; supporting and collaborating with patients through advocacy groups and cancer leagues. Problem Scientifi c challenges • Connective tissue tumours: a collection of rare tumours. • Molecular characterisation is routine for few tumours, in progress for other tumours but unknown for most tumours. • There is a need for harmonisation of research activities in the following fi elds: • molecular characterisation of these tumours, • functional genomics. • Pharmacology: target characterisation and validation. • Promotion of clinical and translational research. • Improvement of medical practices. • Education of the physicians for CPGs. • Epidemiology and medical economics. Medical challenges • Demonstrated ‘proof of concept’ for several connective tissue subtypes. • Targeted oncogene treatments are active treatments. • Harmonisation of research activities, medical practices and education in a context where: • patients are not always treated in specialised centres; • most patients are not treated according to CPGs; • structured clinical research and TR in large centres and network. • Medical practices do not follow clinical practice guidelines for more than 60 % of patients in most western countries so there is a need for education of physician and patients. Economical challenges Health: Inappropriate management results in increased costs. Survival and functional disabilities in adults and children. Identifi cation of novel targets and treatment: Generate intellectual propriety. Commercialisation of new agents. Transfer towards industrial partners: Perform rapid proof of concept clinical trials. Generate synergy between European academia and industry. Political challenges Strengthen and harmonise European research in these rare tumours: Establish the network as the worldwide leading force for research in these rare tumours. Promote academic and industrial collaborations: Generate a network with integrated joint research progra m mes. Include new partners from academia, industry and patients advocacy groups. Ensure the long term viability of the network. BIOLOGY 23
Page 1 and 2: PROJECT SYNOPSES CANCER RESEARCH PR
Page 3 and 4: CANCER RESEARCH PROJECTS FUNDED UND
Page 5 and 6: TABLE OF CONTENTS FOREWORD - CANCER
Page 7 and 8: Prevention 97 EPIC 98 EUROCADET 100
Page 9 and 10: CANCER: COMBATING A COMPLEX DISEASE
Page 11 and 12: Biology Cancer is a disease ethat t
Page 13 and 14: p53 activators ASPP Partner 5 NFkap
Page 15 and 16: Keywords | Angiogenesis | vasculoge
Page 17 and 18: Keywords | Tumour-host interactions
Page 19 and 20: Keywords | Breast | metastasis | ge
Page 21 and 22: Keywords | Identifi cation of novel
Page 23: Keywords | Systems biology | modell
Page 27 and 28: • public health research coupled
Page 29 and 30: Expected results We will construct
Page 31 and 32: Potential applications Our DNA is u
Page 33 and 34: Microscopic examination of tissue s
Page 35 and 36: Pluripotent embryonic stem cells ar
Page 37 and 38: • Decryption of the leukaemia cel
Page 39 and 40: • identifi cation of molecular ta
Page 41 and 42: A B C LT-HSC CSC The Cancer Stem Ce
Page 43 and 44: X-ray diff raction of target drug c
Page 45 and 46: using pathway-specifi c reporter ce
Page 47 and 48: Keywords | Kinases | pediatric panc
Page 49 and 50: Keywords | Lymphangiogenesis | angi
Page 51 and 52: Keywords | Breast cancer | metastas
Page 53 and 54: Keywords | Mitosis | phosphorylatio
Page 55 and 56: Keywords | Therapy | genome | telom
Page 57 and 58: Keywords | Multiple myeloma | cance
Page 59 and 60: Keywords | p53 tumour suppressor |
Page 61 and 62: Development of eff ective anti-canc
Page 63 and 64: Coordinator Patrick A. Curmi INSERM
Page 65 and 66: Drosophila as a model system for tu
Page 67 and 68: Normal cell growth and epithelial l
Page 69 and 70: effi ciently with cancer cell proli
Page 71 and 72: A high-throughput assay of transcri
Page 73 and 74: Coordinator Ewa Sikora Nencki Insti
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Expected results The SIROCCO consor
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Keywords | Epigenetics | gene regul
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Keywords | Hereditary | tricarboxyl
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Keywords | HSV-1 | hepatocellular c
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Keywords | Apoptosis | autophagy |
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Keywords | Tumour | host | signalli
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Aetiology The uncontrolled cell gro
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Coordinator Rosalind Eeles Reader i
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The parallelogram approach in CARCI
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Keywords | Melanoma | genetics | na
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Keywords | Virus | bacteria | HPV |
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Keywords | Breast | prostate | gene
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Prevention The fact that preventing
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Coordinator Elio Riboli Imperial Co
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Coordinator Jan Willem Coebergh Joh
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Coordinator Jose M a Benlloch Conse
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BAMOD Breath-Gas Analysis for Molec
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BioCare Molecular Imaging for Biolo
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These centres of excellence will in
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Expected results Optimise the benef
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114 Cell proliferation and apoptosi
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COBRED Colon and Breast cancer Diag
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DASIM Diagnostic Applications of Sy
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Expected results Primarily, the res
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Coordinator John A. Foekens Dept. o
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124 Aim Drop-Top has two major obje
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Coordinator Gorka Ochoa Progenika B
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Expected results The E.E.T.-Pipelin
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e developed by eTUMOUR is likely to
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Coordinator Angel Porgador Ben-Guri
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• the design of a compact assembl
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Potential applications We believe t
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Tumor initiation, progression to ma
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MolDiag-Paca Novel Molecular Diagno
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NEMO Nano based capsule-Endoscopy w
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OVCAD Ovarian Cancer - Diagnosis of
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P-MARK Validation of recently devel
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POC4life Multiparametric quantum do
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PROMET Prostate cancer molecular-or
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Micrometastasis in the bone marrow.
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and pharmaco-kinetics studies. This
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Coordinator Raffaella Giavazzi Isti
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• Development of tools for diagno
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Treatment Two major problems when t
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Coordinator Lluis M. Mir UMR 8121 C
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Potential applications ANGIOSTOP ha
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Green-fl uorescence protein- expres
Page 171 and 172:
Coordinator Robert Hawkins Universi
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Expected results The BACULOGENES pr
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descriptors of the molecules to be
Page 177 and 178:
Keywords | Therapeutic vaccine | im
Page 179 and 180:
Keywords | Cancer chemotherapy | dr
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Keywords | Children | cancer | leuk
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Chimaeric TCR shown in context of n
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Andrea Splendiani Leaf Bioscience s
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Coordinator Anne O’Garra The Medi
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Coordinator Jacques Bartholeyns IDM
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Structure Driven Drug Design The in
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• acquire fundamental knowledge a
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Terry Jones Victoria University of
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Potential applications The use of t
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groups and management structures. T
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T. Barbui Azienda Ospedaliera-Osped
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Keywords | Mantle cell lymphoma | t
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Keywords | Hypoxia | HIF | pericell
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Keywords | Radiation-induced compli
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Keywords | Gene therapy | adenoviru
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Keywords | Dependence receptors | a
Page 213 and 214:
Keywords | Photodynamic therapy | a
Page 215 and 216:
Keywords | Ovarian cancer | thymidy
Page 217 and 218:
Keywords | Quality assurance | clin
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Keywords | Circadian | clocks | cel
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Keywords | Anticancer therapy | onc
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Coordinator Monika Lusky Transgene
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6 000 women over a three-year perio
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Keywords | Solid tumours | apoptosi
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Keywords | Lymphoma | leukaemia | v
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Coordinator Riccardo Dolcetti Centr
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CCPRB Cancer Control using Populati
Page 236 and 237:
EPCRC The European Palliative Care
Page 238 and 239:
EUROCAN+PLUS Feasibility Study for
Page 240 and 241:
EUSTIR A European strategy for the
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NORMOLIFE Development of new therap
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Scientifi c Model Systems The compl
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Performance of benchmarking exercis
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• markers correlating with the im
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Indices - Keywords Indices - Partne
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● disease markers 131 ● DNA dam
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● renal 77 ● replication 219
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Bos, Nico A. 56 Boskovic, Darinka 2
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Geley, Stephan 159 Georgopoulos, Li
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Lingner, Joachim 54 Linial, Michal
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Ragno, Pia 115 Rainford, Martyn 92
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Vernos, Isabelle 22 Veronesi, Umber
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● Centre Hospitalier Universitair
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● IFOM - Fondazione Istituto FIRC
Page 271 and 272:
● National University of Ireland
Page 273 and 274:
● University of Bari 174 ● Univ
Page 275 and 276:
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