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Coordinator<br />
Raffaella Giavazzi<br />
Istituto di Ricerche Farmacologiche<br />
‘Mario Negri’<br />
Milano, Italy<br />
giavazzi@marionegri.it<br />
Partners<br />
Andreas Bikfalvi<br />
INSERM E 0113<br />
Talence, France<br />
a.bikfalvi@angio.u-bordeaux1.fr<br />
Roy Bicknell<br />
<strong>Cancer</strong> <strong>Research</strong> UK<br />
Institute of Molecular Medicine<br />
University of Oxford<br />
Oxford, United Kingdom<br />
r.bicknel@bham.ac.uk<br />
Dario Neri<br />
Department of Chemistry<br />
and Applied Biosciences<br />
Swiss Federal Institute<br />
Zürich, Switzerland<br />
neri@pharma.ethz.ch<br />
156<br />
Isolation of specifi c LIGANDS<br />
(antibodies-small molecules)<br />
➝<br />
Characterization of the<br />
LIGAND/TARGET<br />
➝ ➝ ➝<br />
Conversion of the ligand into<br />
a THERAPEUTIC MOLECULE<br />
(conjugation with<br />
chemotherapy, citokines,<br />
ADEPT)<br />
PRECLINICAL EVALUATION<br />
of the new therapeutic entities<br />
Design of CLINICAL<br />
PROTOCOLS<br />
➝<br />
Evaluation of ligand as<br />
a THERAPEUTIC AGENT<br />
by itself<br />
Flow chart, outlining the main expected results, leading from target identifi cation<br />
to the development of novel anticancer therapeutics.<br />
Barbara Pedley<br />
University College London<br />
London, United Kingdom<br />
b.pedley@ucl.ac.uk<br />
Luciano Zardi<br />
Istituto Giannina Gaslini<br />
Genova, Italy<br />
luciano.zardi@poste.it<br />
Vincent Castronovo<br />
Université de Liège<br />
Liège, Belgium<br />
vcastronovo@ulg.ac.be<br />
Guus van Dongen<br />
VU University Medical Center<br />
Amsterdam, The Netherlands<br />
gams.vandongen@vumc.nl<br />
Matteo Zanda<br />
Consiglio Nazionale delle Ricerche<br />
Milano, Italy<br />
matteo.zanda@polimi.it<br />
Peter Vajkoczy<br />
Ruprecht-Karls-Universität Heidelberg<br />
Mannheim, Germany<br />
peter.vajkoczy@nch.ma.uni-heidelberg.de<br />
Hartwig Kosmehl<br />
Helios Klinikum Erfurt GmbH<br />
Erfurt, Germany<br />
hkosmehl@erfurt.helios-kliniken.de<br />
Ludger Dinkelborg<br />
Radiopharmaceuticals <strong>Research</strong><br />
Schering AG<br />
Berlin, Germany<br />
ludger.dinkelborg@schering.de<br />
Francisca Vitti<br />
Philogen s.r.l.<br />
Siena, Italy<br />
vitti@philogen.it<br />
Pablo Umaña<br />
GLYCART biotechnology AG<br />
Schlieren-Zurich, Switzerland<br />
Pablo.umana@glycart.com<br />
Project number<br />
LSHC-CT-2003-503233<br />
EC contribution<br />
€ 6 000 000<br />
Duration<br />
52 months<br />
Starting date<br />
01/01/2004<br />
Instrument<br />
IP<br />
Project website<br />
www.stromaproject.org<br />
Silvia Marsoni<br />
SENDO Foundation<br />
Milan, Italy<br />
marsonis@sendo-org.it<br />
Didi Jasmin<br />
European School of Haematology<br />
Paris, France<br />
eshdi@chu-stlouis.fr<br />
CANCER RESEARCH PROJECTS FUNDED UNDER THE SIXTH FRAMEWORK PROGRAMME
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