Cancer Research - Europa

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NEMO Nano based capsule-Endoscopy with Molecular Imaging and Optical biopsy Summary Gastrointestinal (GI) malignancy imposes a signifi cant impact on the well-being of the European members. Ageing of the population means that death rate will continue to rise. A report of the IARC (France) indicates insuffi cient compliance to colorectal cancer prevention programs, due to the lack of a simple, patient friendly diagnosis method. The objective of the NEMO project is to develop an advance cancer screening method friendly enough to signifi cantly increase compliance , simplify the diagnosis procedure and increase the sensitivity and specifi city of early detection. The concept of the NEMO approach is to combine capsule endoscopy with nano-based molecular recognition that will highlights cancerous and precancerous lesions in the GI tract thus considerably increases the accuracy and ease of diagnosis. The system will merge few technological platforms: Nanotechnology for targeting and marking the infected organ, Capsule Endoscopy to detect the marked disorder, Capsule manoeuvring technologies to move the autonomous NEMO capsule backwards and forwards in the gastrointestinal tract, as well as miniaturization and low power technologies. A major task of the project is to develop nanocontainers, labelled with targeting agents and fi lled with dyeing material. The administered nanocontainers will be tailored to react with the target and mark the infected organ. Another task is to develop a capsule based on Narrow Band Imaging. This advanced capsule will provide both: visual images of the GI tract and molecular characterization of the disorder. Fusing image and molecular information together, a new medical tool for early cancer detection with high sensitivity and specifi city will be developed. Problem Keywords | <strong>Cancer</strong> | cancer screening | capsule endoscopy | biosensing | Earlier detection of cancer using screening methods is likely to be the most practical way of addressing the epidemic of gastrointestinal cancers. Gastrointestinal cancers are detected mainly by gastroscopy or colonoscopy followed by biopsy. There is good evidence that such screening can fi nd early cancers and that lives can be saved if such early cancers are discovered and removed. Many patients however are reluctant to have screening gastroscopies and colonoscopies because of the discomfort of the procedures. Women especially are reluctant to undergo screening colonoscopy. The acceptability of capsule endoscopy, which is pain free, requires no sedation and does not necessarily entail a hospital visit, is attractive for patients. It is likely that they would fi nd such a screening method much more acceptable than screening colonoscopy for example. It would be very helpful if capsule endoscopic video imaging could be combined with more sensitive and specifi c methods for detection of early cancer to avoid the need for biopsy. Aim The aim of the NEMO project is to develop a new advanced cancer screening method friendly enough to signifi cantly increase compliance, simplify the diagnosis procedure and increase the sensitivity and specifi city of early detection. The system will miniaturize and merge a variety of technological platforms: Nanotechnology for targeting and marking the precancerous tissue capsule endoscopy and capsule manoeuvring technologies to detect the marked disorder. By fusion of image with data of molecular analysis a new medical diagnostic tool may be formed. The use of specifi c optical fi lters used in conjunction with light emitting diodes (LEDs) will be explored to make a miniature narrow band imaging device which can be contained within a capsule endoscope. Narrow band imaging reduces the surface refl ection of broad band illumination and can allow small or fl at precancerous lesions to be seen clearly when they are diffi cult to see with conventional illumination. The combination of conventional and narrow band imaging may be able to provide an overview of the gastrointestinal tract indicating one of many sites of interest. It could be alternated with conventional imaging. Expected results It is expected that the new Capsule Endoscopy screening method will provide information on the presence or absence of cancerous or precancerous situations with high sensitivity and specifi city. We hope to develop a combination of miniature spectral and Magnetic Resonance nanotechnology to create ‘virtual biopsy’ methods and incorporating these within the capsule endoscope. It is also expected that the new autonomous NEMO capsule will be able to move backwards and forwards in the gastrointestinal tract, for example to re-examine a suspicious lesion. Potential applications Conventional endoscopies are usually performed in hospitals; require trained doctors and a nursing staff for monitoring and cleaning the equipment. Endoscopy generally requires insuffl ations to expand the folds of tissue and enhance examination. 142 CANCER RESEARCH PROJECTS FUNDED UNDER THE SIXTH FRAMEWORK PROGRAMME
The procedure is usually associated with sedation because it is painful or at least uncomfortable for the patient and requires time off work to recover from the anaesthesia. Anxiety about the discomfort of endoscopy, especially of colonoscopy, greatly reduces the uptake by patients off ered this type of cancer screening. The aim of the NEMO project is to develop a system off ering an improved clinical solution; Wireless capsule endoscopy is painless, does not need to be administered in hospital and does not require a team of nurses to clean the devices since it is disposable, nor does it require great skill to perform (although skill in interpretation of the images is needed). Thus it addresses the private clinics as well as institutions. The main applications will be to replace FOBT, colonoscopy or gastroscopy as fi rst line screening methods. The combination of wireless capsule endoscopy with advanced optical technologies is likely to make earlier detection much easier and more eff ective than current fl exible endoscopic technologies. Moreover, combining its capability to analyze secretions with the localization, the solution off ers Pancreatic and liver cancer detection as a by-product of stomach screening. Coordinator Elisha Rabinovitz Given Imaging Ltd. Yoqneam, Israel elisha.rabinovitz@givenimaging.com Partners Ake Sivard Zarlink Semiconductor AB Jarfalla, Sweden ake.sivard@zarlink.com Avraham Rubinstein The Hebrew University of Jerusalem Jerusalem, Israel _avri@cc.huji.ac.il EARLY DETECTION, DIAGNOSIS AND PROGNOSIS Meike Reimann-Zawadzki Fraunhofer-Gesellschaft zur Foerderung der Angewandten Forschung e.V. (FhG) Institute for Biomedical Engineering (IBMT) Sulzbach, Germany meike.reimann@ibmt.fraunhofer.de Alberto Lui Fondazione Bruno Kessler (Istituto Trentino di Cultura) Trento, Italy lui@itc.it Jutta Keller Israelitisches Krankenhaus Hamburg, Germany keller@ik-h.de Paul Swain Imperial College of Science, Technology and Medicine Imperial College London London, United Kingdom cp.swain@imperial.ac.uk Heinz Jochim List Indivumed GmbH Hamburg, Germany list@indivumed.com Emil Katz Novamed Ltd. Jerusalem, Israel emilk@novamed.co.il Elie Berdugo Ernst & Young (Israel) LTD. Tel Aviv, Israel Elie.Berdugo@il.ey.com Project number LSHB-CT-2006-037362 EC contribution € 2 832 020 Duration 36 months Starting date 01/11/2006 Instrument STREP Project website http://fcs.itc.it/NEMO/ 143
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PROJECT SYNOPSES CANCER RESEARCH PR
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CANCER RESEARCH PROJECTS FUNDED UND
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TABLE OF CONTENTS FOREWORD - CANCER
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Prevention 97 EPIC 98 EUROCADET 100
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CANCER: COMBATING A COMPLEX DISEASE
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Biology Cancer is a disease ethat t
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p53 activators ASPP Partner 5 NFkap
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Keywords | Angiogenesis | vasculoge
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Keywords | Tumour-host interactions
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Keywords | Breast | metastasis | ge
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Keywords | Identifi cation of novel
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Keywords | Systems biology | modell
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Keywords | Oncology | anticancer th
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• public health research coupled
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Expected results We will construct
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Potential applications Our DNA is u
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Microscopic examination of tissue s
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Pluripotent embryonic stem cells ar
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• Decryption of the leukaemia cel
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• identifi cation of molecular ta
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A B C LT-HSC CSC The Cancer Stem Ce
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X-ray diff raction of target drug c
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using pathway-specifi c reporter ce
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Keywords | Kinases | pediatric panc
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Keywords | Lymphangiogenesis | angi
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Keywords | Breast cancer | metastas
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Keywords | Mitosis | phosphorylatio
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Keywords | Therapy | genome | telom
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Keywords | Multiple myeloma | cance
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Keywords | p53 tumour suppressor |
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Development of eff ective anti-canc
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Coordinator Patrick A. Curmi INSERM
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Drosophila as a model system for tu
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Normal cell growth and epithelial l
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effi ciently with cancer cell proli
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A high-throughput assay of transcri
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Coordinator Ewa Sikora Nencki Insti
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Expected results The SIROCCO consor
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Keywords | Epigenetics | gene regul
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Keywords | Hereditary | tricarboxyl
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Keywords | HSV-1 | hepatocellular c
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Keywords | Apoptosis | autophagy |
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Keywords | Tumour | host | signalli
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Aetiology The uncontrolled cell gro
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Coordinator Rosalind Eeles Reader i
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The parallelogram approach in CARCI
Page 93 and 94: Keywords | Melanoma | genetics | na
Page 95 and 96: Keywords | Virus | bacteria | HPV |
Page 97 and 98: Keywords | Breast | prostate | gene
Page 99 and 100: Prevention The fact that preventing
Page 101 and 102: Coordinator Elio Riboli Imperial Co
Page 103 and 104: Coordinator Jan Willem Coebergh Joh
Page 105: Coordinator Jose M a Benlloch Conse
Page 108 and 109: BAMOD Breath-Gas Analysis for Molec
Page 110 and 111: BioCare Molecular Imaging for Biolo
Page 112 and 113: These centres of excellence will in
Page 114 and 115: Expected results Optimise the benef
Page 116 and 117: 114 Cell proliferation and apoptosi
Page 118 and 119: COBRED Colon and Breast cancer Diag
Page 120 and 121: DASIM Diagnostic Applications of Sy
Page 122 and 123: Expected results Primarily, the res
Page 124 and 125: Coordinator John A. Foekens Dept. o
Page 126 and 127: 124 Aim Drop-Top has two major obje
Page 128 and 129: Coordinator Gorka Ochoa Progenika B
Page 130 and 131: Expected results The E.E.T.-Pipelin
Page 132 and 133: e developed by eTUMOUR is likely to
Page 134 and 135: Coordinator Angel Porgador Ben-Guri
Page 136 and 137: • the design of a compact assembl
Page 138 and 139: Potential applications We believe t
Page 140 and 141: Tumor initiation, progression to ma
Page 142 and 143: MolDiag-Paca Novel Molecular Diagno
Page 146 and 147: OVCAD Ovarian Cancer - Diagnosis of
Page 148 and 149: P-MARK Validation of recently devel
Page 150 and 151: POC4life Multiparametric quantum do
Page 152 and 153: PROMET Prostate cancer molecular-or
Page 154 and 155: Micrometastasis in the bone marrow.
Page 156 and 157: and pharmaco-kinetics studies. This
Page 158 and 159: Coordinator Raffaella Giavazzi Isti
Page 160 and 161: • Development of tools for diagno
Page 163 and 164: Treatment Two major problems when t
Page 165 and 166: Coordinator Lluis M. Mir UMR 8121 C
Page 167 and 168: Potential applications ANGIOSTOP ha
Page 169 and 170: Green-fl uorescence protein- expres
Page 171 and 172: Coordinator Robert Hawkins Universi
Page 173 and 174: Expected results The BACULOGENES pr
Page 175 and 176: descriptors of the molecules to be
Page 177 and 178: Keywords | Therapeutic vaccine | im
Page 179 and 180: Keywords | Cancer chemotherapy | dr
Page 181 and 182: Keywords | Children | cancer | leuk
Page 183 and 184: Chimaeric TCR shown in context of n
Page 185 and 186: Andrea Splendiani Leaf Bioscience s
Page 187 and 188: Coordinator Anne O’Garra The Medi
Page 189 and 190: Coordinator Jacques Bartholeyns IDM
Page 191 and 192: Structure Driven Drug Design The in
Page 193 and 194: • acquire fundamental knowledge a
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Terry Jones Victoria University of
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Potential applications The use of t
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groups and management structures. T
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T. Barbui Azienda Ospedaliera-Osped
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Keywords | Mantle cell lymphoma | t
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Keywords | Hypoxia | HIF | pericell
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Keywords | Radiation-induced compli
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Keywords | Gene therapy | adenoviru
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Keywords | Dependence receptors | a
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Keywords | Photodynamic therapy | a
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Keywords | Ovarian cancer | thymidy
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Keywords | Quality assurance | clin
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Keywords | Circadian | clocks | cel
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Keywords | Anticancer therapy | onc
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Coordinator Monika Lusky Transgene
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6 000 women over a three-year perio
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Keywords | Solid tumours | apoptosi
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Keywords | Lymphoma | leukaemia | v
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Coordinator Riccardo Dolcetti Centr
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CCPRB Cancer Control using Populati
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EPCRC The European Palliative Care
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EUROCAN+PLUS Feasibility Study for
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EUSTIR A European strategy for the
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NORMOLIFE Development of new therap
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Scientifi c Model Systems The compl
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Performance of benchmarking exercis
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• markers correlating with the im
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Indices - Keywords Indices - Partne
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● disease markers 131 ● DNA dam
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● renal 77 ● replication 219
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Bos, Nico A. 56 Boskovic, Darinka 2
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Geley, Stephan 159 Georgopoulos, Li
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Lingner, Joachim 54 Linial, Michal
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Ragno, Pia 115 Rainford, Martyn 92
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Vernos, Isabelle 22 Veronesi, Umber
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● Centre Hospitalier Universitair
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● IFOM - Fondazione Istituto FIRC
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● National University of Ireland
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● University of Bari 174 ● Univ
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