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• the design of a compact assembly of the complete<br />
Anger Camera. The compactness of the assembly will<br />
allow ease of positioning of the instrument close to the<br />
patient’s body surface;<br />
• the realisation of image-reconstruction algorithms and<br />
user interface software running on a common personal<br />
computer.<br />
134<br />
Expected results<br />
• Development of large-areas low-noise Silicon Drift<br />
Detectors.<br />
• Development of high-resolution collimators.<br />
• Development of a high-resolution and compact Anger<br />
Camera based on state-of-the-art technologies.<br />
• Improved diagnostic capabilities thanks to the use of the<br />
camera.<br />
Potential applications<br />
• Improved possibility to implement an eff ective therapy<br />
with higher capability to detect as small as possible concentrations<br />
of tumour cells.<br />
• Eff ective imaging on reduced volume of the biological<br />
tissues: less than 10 x 10 cm2 area of the planar view<br />
(in scintigraphic investigations with one single imaging<br />
head); less than 10 cm total extent on the coronal plane<br />
of the patient’s body being imaged by the acquired<br />
scans (after appropriate rotation of the camera/s on the<br />
annular holder in the tomographic arrangement).<br />
• Measurements on anatomical sites of the target which<br />
usually lead to severe space constraints during acquisition<br />
of the scan.<br />
• Improved use of imaging instrumentation in those conditions<br />
where the patient’s age, condition or physical<br />
disabilities (e.g. patient on wheelchair) prevent an eff ective<br />
use of large detector heads and gantries without<br />
compromising patient comfort.<br />
• Brain tumours.<br />
• Thyroid cancer, particularly diff erentiated carcinomas,<br />
with 99mTc-perthecnetate.<br />
• Parathyroid cancer with 99mTc-sestamibi for preoperative<br />
localisation of parathyroid adenomas with the aim of<br />
surgical planning in MIP interventions (minimally invasive<br />
parathyroidectomy).<br />
• Breast cancer with 99mTc-labelled lipophilic cations (Sesta-<br />
MIBI or tetrofosmin). The most promising application of<br />
the proposed system concern its use in preoperative or<br />
postoperative sites.<br />
In addition, the project off ers innovative approaches to the<br />
diagnosis of tumours in infants and children.<br />
Coordinator<br />
Carlo Fiorini<br />
Politecnico di Milano<br />
Milano, Italy<br />
carlo.fiorini@polimi.it<br />
Partners<br />
Carla Finocchiaro<br />
CF consulting Finanziamenti<br />
Unione europea srl<br />
Milano, Italy<br />
carla.finocchiaro@cf-consulting.it<br />
Leonardo Pepe<br />
L’ACN L’accessorio Nucleare S.R.L.<br />
Cerro Maggiore, Milano, Italy<br />
leonardo.pepe@lacn.it<br />
Lothar Strüder<br />
Max-Planck-Gesellschaft zur Foerderung<br />
der Wissenschaften eV<br />
Munich, Germany<br />
lts@hll.mpg.de<br />
Project number<br />
LSHC-CT-2006-037737<br />
EC contribution<br />
€ 1 715 000<br />
Duration<br />
36 months<br />
Starting date<br />
01/03/2007<br />
Instrument<br />
STREP – SME<br />
Project website<br />
www.hi-cam.org<br />
Principle scheme of the Anger camera based on Silicon Drift Detectors technology<br />
developed in HICAM.<br />
Brian Hutton<br />
University College London<br />
London, United Kingdom<br />
b.hutton@nucmed.ucl.ac.uk<br />
Ugo Guerra<br />
Ospedali Riuniti di Bergamo<br />
Bergamo, Italy<br />
uguerra@ospedaliriuniti.bergamo.it<br />
Ignasi Carrió<br />
Institut de Recerca de l’Hospital de la Santa<br />
Creu i Sant Pau<br />
Barcelona, Spain<br />
Iccario@hsp.santpau.es<br />
Giovanni Lucignani<br />
Università degli Studi di Milano<br />
Milano, Italy<br />
giovanni.lucignani@unimi.it<br />
CANCER RESEARCH PROJECTS FUNDED UNDER THE SIXTH FRAMEWORK PROGRAMME
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