Cancer Research - Europa

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Coordinator Angel Porgador Ben-Gurion University of the Negev Beer-Sheva, Israel angel@bgu.ac.il 132 Partners Rakefet Rosenfeld Procognia Ltd. Ashdod, Israel rakefet.rosenfeld@procognia.com Pauline Rudd NIBRT Dublin, Ireland pauline.rudd@nibrt.ie Jasna Peter-Katalinic Muenster University Muenster, Germany jkp@uni-muenster.de Julien Taieb RNTech Diagnostics Charleroi-Gosselies, Belgium jtaieb.glyfdis@rntech.com Project number LSHB-CT-2006-037661 EC contribution € 2 793 724 Duration 36 months Starting date 01/11/2006 Instrument STREP Project website www.glyfdis.org CANCER RESEARCH PROJECTS FUNDED UNDER THE SIXTH FRAMEWORK PROGRAMME
Keywords | Technological sciences | health sciences | physical sciences | medical imaging | HI-CAM Development of a high-resolution Anger camera for diagnosis and staging of cancer diseases based on state of the art detector technology Summary The purpose of the project is the development of a compact and high-resolution Anger camera to be used in clinical and research environments and which allows earlier and more reliable diagnosis and therapy planning of cancer diseases in specifi c applications where high overall spatial resolution (less than 3 mm) and system compactness (less than 10 x 10 cm 2 fi eld of view) are required. The gamma camera is based on the well-established Anger architecture, where a collimator acts as a mechanical sieve for incoming gamma photons, a continuous scintillator uses the energy of each selectively passed gamma photon to generate visible photons, and an array of photodetectors emits electric signals in response to the absorption of the visible photons. The improvement of performances is based on the use of a particular type of photodetector, the Silicon Drift Detector (SDD), which has recently demonstrated its ability to provide better performance, by comparison with commonly used photomultiplier tubes. The camera is intended for use both single-handedly for planar scintigraphic studies and inserted in an annular holder (gantry) of small diameter for SPECT imaging. Thanks to its compactness and high spatial resolution, it off ers potential applications in early diagnosis of cancer diseases aff ecting areas of the human body which can only be imaged with diffi culty using the large and heavy imaging heads and gantries of commercial Anger cameras. The camera to be developed in the present project also off ers promising perspectives of integration at the system level with MRI instrumentation, thanks to the relative insensitivity of the SDD photodetectors to large magnetic fi elds. The research activity will be organised as follows: the fi rst two years of the three-year project will be dedicated to the development of the SDD-based Anger camera, while the third year will be dedicated to the experimentation of the camera in selected imaging applications related to cancer diagnosis and research. EARLY DETECTION, DIAGNOSIS AND PROGNOSIS Problem The state-of-the-art in the fi eld is represented by a range of commercial systems, usually having large fi eld detectors (~40x50 cm 2 ). These systems are best exploited while performing whole-body SPECT studies since their large, heavy PMT-based detector heads and bulky gantries present diffi - culties in operating close to the patient’s skin for dedicated studies of specifi c, small tissues such as in parathyroid imaging, brain scanning and investigation of kidney cancer in infants. In a realistic clinical setting, at an imaging distance usually rather greater than 20 cm, the overall eff ective spatial resolution is typically 10-16 mm (7-10 mm for brain studies). When a single detector head is used for dedicated scintigraphic studies of small organs, permitting a closer imaging distance, the overall eff ective spatial resolution is limited by both the intrinsic spatial resolution of the system and the collimator. Aim The aim of the project is therefore the development of a new compact and high position resolution (
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PROJECT SYNOPSES CANCER RESEARCH PR
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CANCER RESEARCH PROJECTS FUNDED UND
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TABLE OF CONTENTS FOREWORD - CANCER
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Prevention 97 EPIC 98 EUROCADET 100
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CANCER: COMBATING A COMPLEX DISEASE
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Biology Cancer is a disease ethat t
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p53 activators ASPP Partner 5 NFkap
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Keywords | Angiogenesis | vasculoge
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Keywords | Tumour-host interactions
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Keywords | Breast | metastasis | ge
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Keywords | Identifi cation of novel
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Keywords | Systems biology | modell
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Keywords | Oncology | anticancer th
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• public health research coupled
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Expected results We will construct
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Potential applications Our DNA is u
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Microscopic examination of tissue s
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Pluripotent embryonic stem cells ar
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• Decryption of the leukaemia cel
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• identifi cation of molecular ta
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A B C LT-HSC CSC The Cancer Stem Ce
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X-ray diff raction of target drug c
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using pathway-specifi c reporter ce
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Keywords | Kinases | pediatric panc
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Keywords | Lymphangiogenesis | angi
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Keywords | Breast cancer | metastas
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Keywords | Mitosis | phosphorylatio
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Keywords | Therapy | genome | telom
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Keywords | Multiple myeloma | cance
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Keywords | p53 tumour suppressor |
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Development of eff ective anti-canc
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Coordinator Patrick A. Curmi INSERM
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Drosophila as a model system for tu
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Normal cell growth and epithelial l
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effi ciently with cancer cell proli
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A high-throughput assay of transcri
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Coordinator Ewa Sikora Nencki Insti
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Expected results The SIROCCO consor
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Keywords | Epigenetics | gene regul
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Keywords | Hereditary | tricarboxyl
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Keywords | HSV-1 | hepatocellular c
Page 83 and 84: Keywords | Apoptosis | autophagy |
Page 85 and 86: Keywords | Tumour | host | signalli
Page 87 and 88: Aetiology The uncontrolled cell gro
Page 89 and 90: Coordinator Rosalind Eeles Reader i
Page 91 and 92: The parallelogram approach in CARCI
Page 93 and 94: Keywords | Melanoma | genetics | na
Page 95 and 96: Keywords | Virus | bacteria | HPV |
Page 97 and 98: Keywords | Breast | prostate | gene
Page 99 and 100: Prevention The fact that preventing
Page 101 and 102: Coordinator Elio Riboli Imperial Co
Page 103 and 104: Coordinator Jan Willem Coebergh Joh
Page 105: Coordinator Jose M a Benlloch Conse
Page 108 and 109: BAMOD Breath-Gas Analysis for Molec
Page 110 and 111: BioCare Molecular Imaging for Biolo
Page 112 and 113: These centres of excellence will in
Page 114 and 115: Expected results Optimise the benef
Page 116 and 117: 114 Cell proliferation and apoptosi
Page 118 and 119: COBRED Colon and Breast cancer Diag
Page 120 and 121: DASIM Diagnostic Applications of Sy
Page 122 and 123: Expected results Primarily, the res
Page 124 and 125: Coordinator John A. Foekens Dept. o
Page 126 and 127: 124 Aim Drop-Top has two major obje
Page 128 and 129: Coordinator Gorka Ochoa Progenika B
Page 130 and 131: Expected results The E.E.T.-Pipelin
Page 132 and 133: e developed by eTUMOUR is likely to
Page 136 and 137: • the design of a compact assembl
Page 138 and 139: Potential applications We believe t
Page 140 and 141: Tumor initiation, progression to ma
Page 142 and 143: MolDiag-Paca Novel Molecular Diagno
Page 144 and 145: NEMO Nano based capsule-Endoscopy w
Page 146 and 147: OVCAD Ovarian Cancer - Diagnosis of
Page 148 and 149: P-MARK Validation of recently devel
Page 150 and 151: POC4life Multiparametric quantum do
Page 152 and 153: PROMET Prostate cancer molecular-or
Page 154 and 155: Micrometastasis in the bone marrow.
Page 156 and 157: and pharmaco-kinetics studies. This
Page 158 and 159: Coordinator Raffaella Giavazzi Isti
Page 160 and 161: • Development of tools for diagno
Page 163 and 164: Treatment Two major problems when t
Page 165 and 166: Coordinator Lluis M. Mir UMR 8121 C
Page 167 and 168: Potential applications ANGIOSTOP ha
Page 169 and 170: Green-fl uorescence protein- expres
Page 171 and 172: Coordinator Robert Hawkins Universi
Page 173 and 174: Expected results The BACULOGENES pr
Page 175 and 176: descriptors of the molecules to be
Page 177 and 178: Keywords | Therapeutic vaccine | im
Page 179 and 180: Keywords | Cancer chemotherapy | dr
Page 181 and 182: Keywords | Children | cancer | leuk
Page 183 and 184: Chimaeric TCR shown in context of n
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Andrea Splendiani Leaf Bioscience s
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Coordinator Anne O’Garra The Medi
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Coordinator Jacques Bartholeyns IDM
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Structure Driven Drug Design The in
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• acquire fundamental knowledge a
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Terry Jones Victoria University of
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Potential applications The use of t
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groups and management structures. T
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T. Barbui Azienda Ospedaliera-Osped
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Keywords | Mantle cell lymphoma | t
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Keywords | Hypoxia | HIF | pericell
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Keywords | Radiation-induced compli
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Keywords | Gene therapy | adenoviru
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Keywords | Dependence receptors | a
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Keywords | Photodynamic therapy | a
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Keywords | Ovarian cancer | thymidy
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Keywords | Quality assurance | clin
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Keywords | Circadian | clocks | cel
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Keywords | Anticancer therapy | onc
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Coordinator Monika Lusky Transgene
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6 000 women over a three-year perio
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Keywords | Solid tumours | apoptosi
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Keywords | Lymphoma | leukaemia | v
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Coordinator Riccardo Dolcetti Centr
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CCPRB Cancer Control using Populati
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EPCRC The European Palliative Care
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EUROCAN+PLUS Feasibility Study for
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EUSTIR A European strategy for the
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NORMOLIFE Development of new therap
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Scientifi c Model Systems The compl
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Performance of benchmarking exercis
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• markers correlating with the im
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Indices - Keywords Indices - Partne
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● disease markers 131 ● DNA dam
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● renal 77 ● replication 219
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Bos, Nico A. 56 Boskovic, Darinka 2
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Geley, Stephan 159 Georgopoulos, Li
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Lingner, Joachim 54 Linial, Michal
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Ragno, Pia 115 Rainford, Martyn 92
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Vernos, Isabelle 22 Veronesi, Umber
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● Centre Hospitalier Universitair
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● IFOM - Fondazione Istituto FIRC
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● National University of Ireland
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● University of Bari 174 ● Univ
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HOW TO OBTAIN EU PUBLICATIONS Our p
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