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Expected results<br />
The E.E.T.-Pipeline provides a comprehensive, multi-team<br />
approach for improving ET diagnostics and treatment by<br />
the integration, assessment and validation of information<br />
generated by basic research utilising high-throughput technologies.<br />
In this integrated post-genomic research eff ort, we<br />
conceive dual pipelines concentrating on:<br />
• state-of-the-art diagnostics;<br />
• innovative drug development and pre-clinical testing, in<br />
order to channel these eff orts. We aim to close the gap<br />
between basic and clinical research by focusing on the<br />
initial evaluation and characterisation of a selected subset<br />
of identifi ed genes, proteins and biological pathways<br />
contributing to malignant transformation or progression<br />
of ET.<br />
Potential applications<br />
This integration of research capacities is expected to enable<br />
the participating SMEs to develop novel, biology-based<br />
therapies for disseminated disease, which will complement<br />
current protocols with more specifi c and less toxic alternatives.<br />
We aim to provide a platform to support the initial<br />
phase of development of new, well tolerated disease- and<br />
patient-adapted anti-tumour strategies.<br />
128<br />
A B<br />
C D<br />
Custom-made tissue microarray for validation of identifi ed novel target proteins<br />
in embryonal tumor tissue.<br />
Coordinator<br />
Angelika Eggert<br />
University Children’s<br />
Hospital Essen<br />
Essen, Germany<br />
angelika.eggert@uk-essen.de<br />
Partners<br />
Manfred Schwab<br />
German <strong>Cancer</strong> <strong>Research</strong> Center<br />
Heidelberg, Germany<br />
Roland Eils<br />
German <strong>Cancer</strong> <strong>Research</strong> Center<br />
Heidelberg, Germany<br />
Saso Dzeroski<br />
Jozef Stefan Institute<br />
Ljubljana, Slovenia<br />
Michael Grotzer<br />
University Children’s<br />
Hospital of Zurich<br />
Zurich, Switzerland<br />
Project number<br />
LSHC-CT-2006-037260<br />
EC contribution<br />
€ 4 000 000<br />
Duration<br />
36 months<br />
Starting date<br />
01/01/2007<br />
Instrument<br />
STREP<br />
Project website<br />
www.eet-pipeline.eu<br />
Heinrich Kovar<br />
Children’s <strong>Cancer</strong><br />
<strong>Research</strong> Institute<br />
Vienna, Austria<br />
Olivier Delattre<br />
Institut Curie<br />
Paris, France<br />
Massimo Zollo<br />
Ceinge-Biotecnologie<br />
Avanzate S.C. a.r.l.<br />
Napoli, Italy<br />
Frank Speleman<br />
Centre for Medical Genetics<br />
Gent, Belgium<br />
Björn Cochlovius<br />
Affitech AS<br />
Oslo, Norway<br />
Alessandro Bulfone<br />
Bioflag Srl<br />
Pula, Italy<br />
CANCER RESEARCH PROJECTS FUNDED UNDER THE SIXTH FRAMEWORK PROGRAMME
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