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Expected results<br />
Specifi c project results will include:<br />
• sets of biomarkers (gene signatures, proteins, metabolites<br />
or a combination of these) that will be considered<br />
clinically relevant for early diagnosis of primary BC and<br />
CRC and relapses;<br />
• central repository system hosting the results from the<br />
technological platforms and the relevant clinical data;<br />
• prospective clinical collection of BC and CRC;<br />
• clinical validation for the diagnostic potential of subsets of<br />
the identifi ed biomarkers in comparison to existing biomarkers<br />
and to currently available imaging techniques;<br />
• preclinical models for the biomarker evaluation and<br />
biological studies.<br />
Potential applications<br />
Diagnostic kit for the detection of cancer recurrence and<br />
metastasis, with the longer term goal to develop early<br />
cancer detection tests amenable for population screening.<br />
Coordinator<br />
Mariana Guergova-Kuras<br />
BioSystems International<br />
4 rue Pierre Fontaine<br />
91058 Evry cedex, France<br />
mariana.kuras@biosys-intl.com<br />
Partners<br />
Andras Guttman<br />
University of Innsbruck<br />
Horváth Laboratory<br />
of Bioseparation Sciences<br />
Institute of Analytical Chemistry<br />
and Radiochemistry<br />
Leopold-Franzens University<br />
Innrain 66,<br />
6020 Innsbruck, Austria<br />
andras.guttman@uibk.ac.at<br />
Klaus Weinberger<br />
Biocrates<br />
BIOCRATES Life Sciences GmbH<br />
Innrain 66/2<br />
6020 Innsbruck, Austria<br />
klaus.weinberger@biocrates.com<br />
EARLY DETECTION, DIAGNOSIS AND PROGNOSIS<br />
Fabienne Hermitte<br />
Ipsogen<br />
Luminy Biotech Entreprises<br />
Case 923 – 163, av. De Luminy<br />
13288 Marseille Cedex, France<br />
Hermitte@ipsogen.com<br />
Xavier Sastre-Garau<br />
Institut Curie<br />
Cell Biology Department<br />
Department Translational <strong>Research</strong><br />
26 rue d’Ulm,<br />
75248 Paris cedex 05, France<br />
xavier.sastre@curie.net<br />
David Malka<br />
Institut Gustave-Roussy<br />
39 rue Camille Desmoulins<br />
94805 Villejuif Cedex, France<br />
david.malka@igr.fr<br />
Laszlo Fesus<br />
University of Debrecen<br />
Department of Biochemistry<br />
and Molecular Biology<br />
Medical and Health Science Center<br />
Egyetem Ter 1.<br />
4010 Debrecen, Hungary<br />
fesus@dote.hu<br />
Jaak Vilo<br />
University of Tartu<br />
Ülikooli 18<br />
50090 Tartu, Estonia<br />
jaak.vilo@ut.ee<br />
Bruno Cucinelli<br />
Arttic SA<br />
58A rue du dessous des berges<br />
75013 Paris, France<br />
cobred@arttic.fr<br />
Project number<br />
LSHB-CT-2007-037730<br />
EC contribution<br />
€ 2 985 102<br />
Duration<br />
36 months<br />
Starting date<br />
01/03/2007<br />
Instrument<br />
STREP<br />
Project website<br />
www.cobred.eu<br />
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