Cancer Research - Europa

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BAMOD Breath-Gas Analysis for Molecular- Oriented Detection of Minimal Diseases Summary Keywords | Exhaled breath analysis | lung cancer | oesophageal cancer | medical diagnosis | therapeutic monitoring | gas chromatography | mass spectrometry | PTR-MS | SIFT-MS | laser spectrometry | ion mobility spectrometry | <strong>Cancer</strong> is one of the leading causes of death in Europe and the western world. At present, diagnosis of cancer occurs late in the course of the disease since available diagnostic methods are not sufficiently sensitive and specific. An early diagnosis of cancer would improve prognosis and treatment, and could save thousands of lives a year. There is strong evidence to suggest that particulate cancers can be detected by a molecular analysis of exhaled air. Breath analysis represents a new diagnostic technique that is without risk for the patient, even if repeated frequently, and can provide information beyond conventional analysis of blood and urine. Recent results suggest that detection of diff erent kinds of cancer is possible by means of breath analysis in the very early stages of the disease. This project is focused on the diagnosis of minimal disease and early stages of lung and oesophageal cancer. The analytical techniques will be gas chromatography with mass spectrometric detection (GC-MS), proton transfer reaction mass spectrometry (PTR-MS), selected ion flow tube mass spectrometry (SIFT-MS), laser spectrometry and ion mobility spectrometry (IMS). In order to establish a reliable clinical method for the diagnosis of minimal residual cancer diseases, clinical expertise, basic research and technical development is necessary. The European consortium set up to pursue this research work involves specialists with skills in the fields of basic and clinical research, and analytical instrument development. Thus, the consortium has the expertise to investigate and screen exhaled breath for many molecular species, to identify specific cancer markers and the statistical tools to treat the data. Problem <strong>Cancer</strong> is one of the leading causes of death in the western world. More than 940 000 people died of lung cancer in Europe in the year 2000. These diseases have a tremendous impact on healthcare systems and economics. At present, the diagnosis of cancer often happens late in the course of the disease; early diagnosis would improve prognosis and treatment and could save thousands of lives. 106 CANCER RESEARCH PROJECTS FUNDED UNDER THE SIXTH FRAMEWORK PROGRAMME Aim The objectives of the project are: • the identification of sensitive and specific molecular marker sets in human breath for the detection of early cancer stages; • the development of reliable analytical methods to detect these markers in the clinical environment; • the production of easy-to-use and non-expensive equipment to facilitate breath analysis as a novel cancer screening tool. The proposal is centred on five studies: in vivo lung cancer and oesophageal cancer studies, a study of cancer cell lines in vitro, a study of immune-system related cells and a study of bacterial cell lines. The SMEs in our consortium will develop analytical methodology for subsequent use in clinical applications. Expected results The major objective is the establishment of a non-invasive, breathbased test for early detection of lung and oesophageal cancer. The development of sensitive detection technology, a database of molecular markers related to cancer, and the development of specific sensors for such markers is anticipated. Potential applications The developed breath-based tests for the detection of lung and oesophageal cancer should be introduced to assist clinical diagnosis and therapeutic monitoring.
Detection of lung and oesophageal cancer based on exhaled breath. Coordinator Anton Amann Innsbruck Medical University Dept. of Anaesthesia and General Intensive Care Innsbruck, Austria anton.amann@i-med.ac.at Partners Jochen Schubert Universität Rostock Rostock, Germany Rosa Margesin Leopold-Franzens-Universtität Innsbruck Innsbruck, Austria Karl Unterkofler Vorarlberg University of Applied Sciences Dornbirn, Austria Nandor Marczin Imperial College London London, United Kingdom EARLY DETECTION, DIAGNOSIS AND PROGNOSIS Manfred Mürtz Universtitätsklinikum Düsseldorf Düsseldorf, Germany Boguslaw Buszewski Nicolaus Copernicus University Torun, Poland Ireneusz Sliwka Polish Academy of Sciences Krakow, Poland Viktor Witkovsky Slovak Academy of Sciences Bratislava, Slovakia Kerstin Wex IT Dr. Gambert GmbH Wismar, Germany Armin Hansel IONIMED Analytik GmbH Innsbruck, Austria Patrick Spanel Trans Spectra Limited Keele, United Kingdom Jörg Ingo Baumbach Institute for Analytical Sciences Dortmund, Germany Project number LSHC-CT-2005-019031 EC contribution € 2 998 228 Duration 36 months Starting date 01/02/2006 Instrument STREP Project website eu-proposal. voc-research.at 107
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PROJECT SYNOPSES CANCER RESEARCH PR
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CANCER RESEARCH PROJECTS FUNDED UND
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TABLE OF CONTENTS FOREWORD - CANCER
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Prevention 97 EPIC 98 EUROCADET 100
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CANCER: COMBATING A COMPLEX DISEASE
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Biology Cancer is a disease ethat t
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p53 activators ASPP Partner 5 NFkap
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Keywords | Angiogenesis | vasculoge
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Keywords | Tumour-host interactions
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Keywords | Breast | metastasis | ge
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Keywords | Identifi cation of novel
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Keywords | Systems biology | modell
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Keywords | Oncology | anticancer th
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• public health research coupled
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Expected results We will construct
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Potential applications Our DNA is u
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Microscopic examination of tissue s
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Pluripotent embryonic stem cells ar
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• Decryption of the leukaemia cel
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• identifi cation of molecular ta
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A B C LT-HSC CSC The Cancer Stem Ce
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X-ray diff raction of target drug c
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using pathway-specifi c reporter ce
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Keywords | Kinases | pediatric panc
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Keywords | Lymphangiogenesis | angi
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Keywords | Breast cancer | metastas
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Keywords | Mitosis | phosphorylatio
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Keywords | Therapy | genome | telom
Page 57 and 58: Keywords | Multiple myeloma | cance
Page 59 and 60: Keywords | p53 tumour suppressor |
Page 61 and 62: Development of eff ective anti-canc
Page 63 and 64: Coordinator Patrick A. Curmi INSERM
Page 65 and 66: Drosophila as a model system for tu
Page 67 and 68: Normal cell growth and epithelial l
Page 69 and 70: effi ciently with cancer cell proli
Page 71 and 72: A high-throughput assay of transcri
Page 73 and 74: Coordinator Ewa Sikora Nencki Insti
Page 75 and 76: Expected results The SIROCCO consor
Page 77 and 78: Keywords | Epigenetics | gene regul
Page 79 and 80: Keywords | Hereditary | tricarboxyl
Page 81 and 82: Keywords | HSV-1 | hepatocellular c
Page 83 and 84: Keywords | Apoptosis | autophagy |
Page 85 and 86: Keywords | Tumour | host | signalli
Page 87 and 88: Aetiology The uncontrolled cell gro
Page 89 and 90: Coordinator Rosalind Eeles Reader i
Page 91 and 92: The parallelogram approach in CARCI
Page 93 and 94: Keywords | Melanoma | genetics | na
Page 95 and 96: Keywords | Virus | bacteria | HPV |
Page 97 and 98: Keywords | Breast | prostate | gene
Page 99 and 100: Prevention The fact that preventing
Page 101 and 102: Coordinator Elio Riboli Imperial Co
Page 103 and 104: Coordinator Jan Willem Coebergh Joh
Page 105: Coordinator Jose M a Benlloch Conse
Page 110 and 111: BioCare Molecular Imaging for Biolo
Page 112 and 113: These centres of excellence will in
Page 114 and 115: Expected results Optimise the benef
Page 116 and 117: 114 Cell proliferation and apoptosi
Page 118 and 119: COBRED Colon and Breast cancer Diag
Page 120 and 121: DASIM Diagnostic Applications of Sy
Page 122 and 123: Expected results Primarily, the res
Page 124 and 125: Coordinator John A. Foekens Dept. o
Page 126 and 127: 124 Aim Drop-Top has two major obje
Page 128 and 129: Coordinator Gorka Ochoa Progenika B
Page 130 and 131: Expected results The E.E.T.-Pipelin
Page 132 and 133: e developed by eTUMOUR is likely to
Page 134 and 135: Coordinator Angel Porgador Ben-Guri
Page 136 and 137: • the design of a compact assembl
Page 138 and 139: Potential applications We believe t
Page 140 and 141: Tumor initiation, progression to ma
Page 142 and 143: MolDiag-Paca Novel Molecular Diagno
Page 144 and 145: NEMO Nano based capsule-Endoscopy w
Page 146 and 147: OVCAD Ovarian Cancer - Diagnosis of
Page 148 and 149: P-MARK Validation of recently devel
Page 150 and 151: POC4life Multiparametric quantum do
Page 152 and 153: PROMET Prostate cancer molecular-or
Page 154 and 155: Micrometastasis in the bone marrow.
Page 156 and 157: and pharmaco-kinetics studies. This
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Coordinator Raffaella Giavazzi Isti
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• Development of tools for diagno
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Treatment Two major problems when t
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Coordinator Lluis M. Mir UMR 8121 C
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Potential applications ANGIOSTOP ha
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Green-fl uorescence protein- expres
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Coordinator Robert Hawkins Universi
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Expected results The BACULOGENES pr
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descriptors of the molecules to be
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Keywords | Therapeutic vaccine | im
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Keywords | Cancer chemotherapy | dr
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Keywords | Children | cancer | leuk
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Chimaeric TCR shown in context of n
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Andrea Splendiani Leaf Bioscience s
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Coordinator Anne O’Garra The Medi
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Coordinator Jacques Bartholeyns IDM
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Structure Driven Drug Design The in
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• acquire fundamental knowledge a
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Terry Jones Victoria University of
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Potential applications The use of t
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groups and management structures. T
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T. Barbui Azienda Ospedaliera-Osped
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Keywords | Mantle cell lymphoma | t
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Keywords | Hypoxia | HIF | pericell
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Keywords | Radiation-induced compli
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Keywords | Gene therapy | adenoviru
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Keywords | Dependence receptors | a
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Keywords | Photodynamic therapy | a
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Keywords | Ovarian cancer | thymidy
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Keywords | Quality assurance | clin
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Keywords | Circadian | clocks | cel
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Keywords | Anticancer therapy | onc
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Coordinator Monika Lusky Transgene
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6 000 women over a three-year perio
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Keywords | Solid tumours | apoptosi
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Keywords | Lymphoma | leukaemia | v
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Coordinator Riccardo Dolcetti Centr
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CCPRB Cancer Control using Populati
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EPCRC The European Palliative Care
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EUROCAN+PLUS Feasibility Study for
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EUSTIR A European strategy for the
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NORMOLIFE Development of new therap
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Scientifi c Model Systems The compl
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Performance of benchmarking exercis
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• markers correlating with the im
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Indices - Keywords Indices - Partne
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● disease markers 131 ● DNA dam
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● renal 77 ● replication 219
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Bos, Nico A. 56 Boskovic, Darinka 2
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Geley, Stephan 159 Georgopoulos, Li
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Lingner, Joachim 54 Linial, Michal
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Ragno, Pia 115 Rainford, Martyn 92
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Vernos, Isabelle 22 Veronesi, Umber
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● Centre Hospitalier Universitair
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● IFOM - Fondazione Istituto FIRC
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● National University of Ireland
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● University of Bari 174 ● Univ
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