Avicel-plus® GP 1610 Stabilizer - FMC Corporation

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Avicel-plus® GP 1610 Stabilizer (441C) Date: 12/01/2005 GLOVES: No special gloves are required. COMMENTS: ADDITIONAL EXPOSURE LIMITS: MCC: Australia (TWA) 10 mg/m³ Belgium (TWA) 10 mg/m 3 (inhalable dust) China (STEL): 25 mg/m³ China (TWA): 10 mg/m³ Hong Kong (TWA): 10 mg/m³ Ireland (TWA): 10 mg/m³ (inhalable dust) Korea (TWA): 10 mg/m³ New Zealand (TWA): 10 mg/m³ (respirable dust with no asbestos and less than 1% free silica) Singapore (PEL): 10 mg/m³ Switzerland (TWA): 3 mg/m³ MAK (respirable) United Kingdom (STEL): 10 mg/m³ (total inhalable dust) United Kingdom (TWA): 10 mg/m³ (total inhalable dust); 4 mg/m³ (respirable dust) 9. PHYSICAL AND CHEMICAL PROPERTIES ODOR: Slight marine APPEARANCE: White to off-white, dry powder AUTOIGNITION TEMPERATURE: Not applicable BOILING POINT: Not applicable COEFFICIENT OF OIL / WATER: (Octanol/Water) Not available EVAPORATION RATE: (Butyl acetate = 1) Not applicable FLASH POINT: Not applicable MELTING POINT: Not applicable OXIDIZING PROPERTIES: Not applicable PERCENT VOLATILE: Not available pH: 5.5 - 10.0 SOLUBILITY IN WATER: (% by weight) 10% maximum SPECIFIC GRAVITY: (H2O = 1) Approximately 1 g/cc VAPOR DENSITY: (Air = 1) Not applicable VAPOR PRESSURE: Not applicable COMMENTS: EXPLOSIVE PROPERTIES: Microcrystalline cellulose: St-1 Page 4 of 9
Avicel-plus® GP 1610 Stabilizer (441C) Date: 12/01/2005 MINIMUM IGNITION TEMPERATURE: Microcrystalline cellulose: 420°C 10. STABILITY AND REACTIVITY CONDITIONS TO AVOID: None known STABILITY: Stable HAZARDOUS DECOMPOSITION PRODUCTS: None known. 11. TOXICOLOGICAL INFORMATION EYE EFFECTS: No data available for the formulation. MCC/CMC: Non-irritating (rabbit) Carrageenan: Non-irritating (rabbit) SKIN EFFECTS: No data available for the formulation. MCC/CMC: Non-irritating (PII = 0/8.0) (rabbit) Carrageenan: Non-irritating (rabbit) DERMAL LD50: No data available for the formulation. MCC/CMC: > 2,000 mg/kg (rabbit) Carrageenan: > 2,000 mg/kg (rabbit) ORAL LD50: No data available for the formulation. MCC/CMC: > 5,000 mg/kg (rat) Carrageenan: > 5,000 mg/kg (rat) INHALATION LC50: No data available for the formulation. MCC/CMC: > 5.82 mg/l (4 h) (rat) Maximum attainable concentration - zero mortality Carrageenan: > 0.93 mg/l (4 h) (rat) Maximum attainable concentration - zero mortality SENSITIZATION: No data available for the formulation. MCC/CMC: (Skin) Non-sensitizing (guinea pig) Carrageenan: (Skin) Non-sensitizing (guinea pig) ACUTE EFFECTS FROM OVEREXPOSURE: This product is expected to have low oral, dermal and inhalation toxicity. It is expected to be non-irritating to the eyes and skin, and nonsensitizing to the skin. No significant acute toxicological effects are expected. CHRONIC EFFECTS FROM OVEREXPOSURE: No data available for the formulation. Ninety-day feeding studies with microcrystalline cellulose/sodium carboxymethylcellulose blend, in laboratory animals, at levels up to and including 50,000 ppm showed no significant toxicological effects as well as no adverse fetal effects. The maternal/fetal NOELs were > 50,000 ppm. Microcrystalline cellulose/sodium carboxymethylcellulose blend was negative in a battery of standard genotoxic tests. Microcrystalline cellulose is considered an inert dust, which is not toxic to the lungs when exposures are Page 5 of 9
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Avicel-plus® GP 1610 Stabilizer - FMC Corporation

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