Avicel-plus® PS 3625 Stabilizer - FMC Corporation

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Avicel-plus® PS 3625 Stabilizer (61017000-1) Date: 09/18/2009 NIOSH/MSHA, EU CEN or comparable certification organization to protect them against airborne dust. PROTECTIVE CLOTHING: No special clothing is required. GLOVES: No special gloves are required. 9. PHYSICAL AND CHEMICAL PROPERTIES ODOR: Odorless APPEARANCE: Light-tan powder AUTOIGNITION TEMPERATURE: Not applicable BOILING POINT: Not applicable COEFFICIENT OF OIL / WATER: (Octanol/Water) Not available EVAPORATION RATE: (Butyl acetate = 1) Not applicable FLASH POINT: Not applicable MELTING POINT: Not applicable OXIDIZING PROPERTIES: Not applicable PERCENT VOLATILE: Not applicable pH: 5.5 - 9.0 SOLUBILITY IN WATER: (% by weight) 12% maximum SPECIFIC GRAVITY: (H2O=1): Not applicable VAPOR DENSITY: (Air = 1) Not applicable VAPOR PRESSURE: Not applicable COMMENTS: EXPLOSIVE PROPERTIES: Microcrystalline cellulose: St-1 MINIMUM IGNITION TEMPERATURE: Microcrystalline cellulose: 420°C 10. STABILITY AND REACTIVITY CONDITIONS TO AVOID: None known STABILITY: Stable HAZARDOUS DECOMPOSITION PRODUCTS: None known. Page 4 of 9
Avicel-plus® PS 3625 Stabilizer (61017000-1) Date: 09/18/2009 11. TOXICOLOGICAL INFORMATION EYE EFFECTS: No data available for the formulation. MCC/CMC: Non-irritating (rabbit) Carrageenan: Non-irritating (rabbit) SKIN EFFECTS: No data available for the formulation. MCC/CMC: Non-irritating (rabbit) Carrageenan: Non-irritating (rabbit) DERMAL LD50: > 2,000 mg/kg (rabbit) ORAL LD50: No data available for the formulation. MCC/CMC: > 5,000 mg/kg (rabbit) Carrageenan: > 5,000 mg/kg (rat) INHALATION LC50: No data available for the formulation. MCC/CMC: > 5.82 mg/l (4 h) (rat) Carrageenan: > 0.93 mg/l (4 h) (rat) Maximum attainable concentration - zero mortality SENSITIZATION: No data available for the formulation. MCC/CMC: (Skin) Non-sensitizing (guinea pig) Carrageenan: (Skin) Non-sensitizing (guinea pig) ACUTE EFFECTS FROM OVEREXPOSURE: This product has low oral, dermal and inhalation toxicity. It is non-irritating to the eyes and skin, and non-sensitizing to the skin. No significant acute toxicological effects are expected. CHRONIC EFFECTS FROM OVEREXPOSURE: No data available for the formulation. Ninety-day feeding studies with microcrystalline cellulose/sodium carboxymethylcellulose blend, in laboratory animals, at levels up to and including 50,000 ppm showed no significant toxicological effects as well as no adverse fetal effects. The maternal/fetal NOELs were > 50,000 ppm. Microcrystalline cellulose/sodium carboxymethylcellulose blend was negative in a battery of standard genotoxic tests. Microcrystalline cellulose is considered an inert dust, which is not toxic to the lungs when exposures are properly controlled. Long term and lifetime feeding studies with carrageenan in laboratory animals were negative, as were reproductive outcomes and mutagenicity studies. CARCINOGENICITY: Chemical Name IARC NTP OSHA Other Carrageenan 3 Not listed Not listed (ACGIH) Not listed 12. ECOLOGICAL INFORMATION ENVIRONMENTAL DATA: No data available for the formulation. Microcrystalline cellulose is inherently biodegradable in soil. It biodegrades in soil at a rate comparable to corn starch. Page 5 of 9
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Avicel-plus® PS 3625 Stabilizer - FMC Corporation

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