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Obesity in pregnancy

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If you are obese, your BMI is 30.0 + before <strong>pregnancy</strong>. About 1 <strong>in</strong> 4 women of reproductive age <strong>in</strong> the<br />

United States is obese. 1<br />

DETERMINATION of OBESITY<br />

The World Health Organization (WHO) and the National Institutes of Health (NIH) def<strong>in</strong>e weight by body<br />

mass <strong>in</strong>dex (BMI) as follows 2,3 :<br />

BMI Weight Classification<br />

18.5-24.9 Normal<br />

25.0-29.9 Overweight<br />

Obese<br />

30.0-34.9 Class I<br />

35.0-39.9 Class II<br />

>=40.0 Class III<br />

Onl<strong>in</strong>e BMI Calculator 3<br />

The 1999-2002 National Health and Nutrition Survey (NHANES) found that approximately one third of adult<br />

women are obese, with this be<strong>in</strong>g greatest among non-Hispanic black women (49%) compared with Mexican-<br />

American women (38%) and non-Hispanic white women (31%.) 4<br />

RECOMMENDATIONS FOR WEIGHT GAIN IN PREGNANCY 5<br />

Height and weight should be recorded at the <strong>in</strong>itial prenatal visit to determ<strong>in</strong>e BMI.<br />

Prenatal weight ga<strong>in</strong> recommendations are based off of the Institute of Medic<strong>in</strong>e (IOM) guidel<strong>in</strong>es as follows:<br />

Normal weight women: 25-35 lbs<br />

Overweight women: 15-25 lbs<br />

Obese women: 15 lb<br />

See the newest chart from the National Institute of Medic<strong>in</strong>e for more detail: Table 1, pg 2.<br />

TRACKING YOUR WEIGHT GAIN<br />

Pregnant women can chart their weight ga<strong>in</strong> alongside the average pattern curve, as <strong>in</strong> the example provided by<br />

March of Dimes.<br />

BE CONSISTENT: Weight should be taken at the same time of day, <strong>in</strong> the same way (clothed or not).<br />

Weight Ga<strong>in</strong> Chart Example 6<br />

COMPLICATIONS DURING PREGNANCY- The Mother<br />

Women who are overweight when they get pregnant and dur<strong>in</strong>g their <strong>pregnancy</strong> are at higher risk for many<br />

complications. They <strong>in</strong>clude the follow<strong>in</strong>g:<br />

2<br />

Infertility: Some overweight women are unable to get pregnant.<br />

Thursday, December 06, 2012


Miscarriage: The baby may die <strong>in</strong> the womb prior to 20 weeks of <strong>pregnancy</strong>.<br />

Stillbirth: The baby may die <strong>in</strong> the womb after 20 weeks of <strong>pregnancy</strong> but before birth.<br />

Preeclampsia and High Blood Pressure: Only pregnant women are able to get preeclampsia, and the risk<br />

is <strong>in</strong>creased with be<strong>in</strong>g overweight. It can <strong>in</strong>crease the chances of a preterm birth (birth prior to 37 weeks<br />

of completed <strong>pregnancy</strong>.)<br />

Gestational Diabetes: Diabetes dur<strong>in</strong>g <strong>pregnancy</strong><br />

Labor and Birth Complications:<br />

Large for gestational age baby<br />

Increased risk for cesarean section<br />

Complications with anesthesia<br />

Increased risk for post-surgical wound <strong>in</strong>fection<br />

Higher rates of surgical blood loss<br />

Intrapartum complications, such as difficulty estimat<strong>in</strong>g fetal weight, <strong>in</strong>ability<br />

to obta<strong>in</strong> external fetal heart rate and uter<strong>in</strong>e contraction patterns, and trouble<br />

perform<strong>in</strong>g emergent cesarean delivery.<br />

Studies have shown that Class I and II obesity are associated with a higher risk of gestational diabetes,<br />

gestational hypertension, preeclampsia, and fetal macrosomia <strong>in</strong> comparison with a BMI of less than<br />

30 7,8,9,10,11 . Additionally, the cesarean delivery rate was seem to <strong>in</strong>crease with BMI. 7<br />

Operative and postoperative complications have been shown to <strong>in</strong>clude higher rates of excessive blood loss,<br />

<strong>in</strong>creased operative time, wound <strong>in</strong>fection, and endometriosis. 12, 13, 14 Additionally, surgery <strong>in</strong> obese women<br />

can lead to anesthetic challenges, with difficulty <strong>in</strong> plac<strong>in</strong>g epidural, need for multiple attempts, and respiratory<br />

events from <strong>in</strong>tubation problems. 15<br />

POST PREGNANCY COMPLICATIONS<br />

Incremental <strong>in</strong>creases <strong>in</strong> gestational weight ga<strong>in</strong> beyond that recommended for obese women substantially<br />

<strong>in</strong>crease the risk of weight retention at 1 year postpartum. 16<br />

COMPLICATIONS FOR THE BABY<br />

A majority of babies born to overweight or obese mothers are born healthy, however, there is an <strong>in</strong>creased risk<br />

for many complications if a woman is overweight or obese dur<strong>in</strong>g <strong>pregnancy</strong>. These <strong>in</strong>clude:<br />

Birth defects, particularly neural tube defects<br />

Preterm birth<br />

Injury, such as shoulder dystocia dur<strong>in</strong>g birth, due to large size of the baby.<br />

Death after birth<br />

Large size (macrosomia)<br />

<strong>Obesity</strong> dur<strong>in</strong>g childhood<br />

Thursday, December 06, 2012<br />

Some studies have reported a greater rate of premature delivery for obese women than those who are of a<br />

normal weight, 8,17 but some have reported that pre-<strong>pregnancy</strong> obesity is associated with a lower rate of<br />

spontaneous preterm birth, 18 thus this issue is still unclear.<br />

3


As far as neural tube defects, it has been shown that the number among obese mothers is double that of normal<br />

weight mothers (after correct<strong>in</strong>g for diabetes as a potential confound<strong>in</strong>g variable.) 19,20,21<br />

Many studies have shown that maternal obesity and excessive weight ga<strong>in</strong> <strong>in</strong> <strong>pregnancy</strong> are <strong>in</strong> fact associated<br />

with macrosomia, 9, 22,23,24 and that these babies are <strong>in</strong> turn at <strong>in</strong>creased risk for childhood obesity. 10, 25<br />

HEALTH CARE COST BURDEN<br />

<strong>Obesity</strong> <strong>in</strong> <strong>pregnancy</strong> has been shown by the CDC to be associated with an <strong>in</strong>crease <strong>in</strong> the use of health care<br />

services. These can <strong>in</strong>clude:<br />

Greater use of <strong>in</strong>patient and outpatient health care services<br />

Increased length of hospital stays for delivery<br />

Greater use of physician services<br />

Less use of services by nurse practitioners and physician assistants dur<strong>in</strong>g prenatal visits<br />

Increased prenatal care costs<br />

The ma<strong>in</strong> study referenced was adjusted for age, race/ethnic group, level of education, and parity. In this study,<br />

it was found that:<br />

The mean length of hospital stay was significantly longer for women who were overweight, obese, very<br />

obese, and extremely obese <strong>in</strong> comparison with women with a normal BMI, particularly due to <strong>in</strong>creased<br />

rates of cesarean delivery and obesity-related high-risk conditions.<br />

A higher than normal BMI was associated with significantly more prenatal fetal tests, obstetrical<br />

ultrasonographic exam<strong>in</strong>ations, medications from outpatient pharmacies, calls to the department of<br />

obstetrics and gynecology, and prenatal visits with physicians.<br />

Fewer of these visits were with nurse practitioners and physician assistants. 26<br />

The costs are not only limited to the mother and her delivery. Babies born to obese mothers often need<br />

admission to neonatal <strong>in</strong>tensive care units more often than those born to normal weight mothers. 27<br />

Unfortunately, very few studies have been done look<strong>in</strong>g at the economic impact of maternal obesity. There are<br />

no good studies to show robust estimates of actual cost. 38 Even without these specific numbers, it seems clear<br />

that the impact is significant, and hopefully <strong>in</strong> the near future, more work will be done to support this.<br />

RISK REDUCTION PRE-PREGNANCY (Primary Prevention)<br />

Before conceiv<strong>in</strong>g:<br />

Thursday, December 06, 2012<br />

Get a preconception check-up<br />

Discuss healthy eat<strong>in</strong>g and exercise with your health care provider (to help lose weight before<br />

<strong>pregnancy</strong>)<br />

Create a healthy eat<strong>in</strong>g plan, with the help of the U.S.D.A. Choose My Plate onl<strong>in</strong>e tool<br />

Consider weight reduction surgery<br />

WEIGHT LOSS SURGERY PRE-PREGNANCY<br />

Weight loss surgery before <strong>pregnancy</strong> can decrease the chances of experienc<strong>in</strong>g weight-related <strong>pregnancy</strong><br />

4


complications, if it successfully leads to a susta<strong>in</strong>ed reduction <strong>in</strong> weight. Many providers therefore will<br />

recommend wait<strong>in</strong>g at least 1 year after the surgery before try<strong>in</strong>g to get pregnant. While uncommon, women<br />

who have undergone weight reduction surgery may have different complications dur<strong>in</strong>g <strong>pregnancy</strong>, which<br />

should be discussed with the health care provider prior to try<strong>in</strong>g to conceive.<br />

Early studies on <strong>pregnancy</strong> after bariatric (weight loss) surgery showed complications such as gastro<strong>in</strong>test<strong>in</strong>al<br />

bleed<strong>in</strong>g28 , anemia29 , <strong>in</strong>trauter<strong>in</strong>e growth restriction30 , and neural tube defects, 31, 32 however more recent<br />

studies suggest that previous bariatric surgery is not associated with adverse per<strong>in</strong>atal outcomes. 33, 34<br />

Research has shown that pregnancies after bariatric surgery are <strong>in</strong> fact associated with fewer complications<br />

such as gestational diabetes, hypertension, macrosomia, and cesarean delivery than <strong>in</strong> obese women who had<br />

not had the surgery. 34, 35,36<br />

Suggestions for women th<strong>in</strong>k<strong>in</strong>g of conceiv<strong>in</strong>g, who have undergone bariatric surgery:<br />

Those with gastric band<strong>in</strong>g are at risk of becom<strong>in</strong>g pregnant unexpectedly after weight loss follow<strong>in</strong>g the<br />

surgery35 Patients should be advised to delay <strong>pregnancy</strong> 12-18 months after surgery<br />

Women with a gastric band should be monitored by their surgeon <strong>in</strong> case adjustment of the band may<br />

become necessary<br />

Patients should be monitored for nutritional deficiencies, and vitam<strong>in</strong> supplementation should be done as<br />

necessary<br />

RISK REDUCTION DURING PREGNANCY (Secondary Prevention)<br />

Dur<strong>in</strong>g <strong>pregnancy</strong>:<br />

Get early, regular prenatal care<br />

Determ<strong>in</strong>e the appropriate level of weight ga<strong>in</strong> by BMI, and physicians should discuss this with the<br />

patient<br />

Exercise most days (as directed by the health care provider). Safe exercises <strong>in</strong>clude walk<strong>in</strong>g, swimm<strong>in</strong>g,<br />

rid<strong>in</strong>g a stationary bike, tak<strong>in</strong>g <strong>pregnancy</strong> aerobics, or yoga classes.<br />

Dietary modifications can help reduce maternal weight ga<strong>in</strong> and improve obstetric outcome <strong>in</strong><br />

overweight pregnant women37 Preconception counsel<strong>in</strong>g ans assessment are highly recommended due to the <strong>in</strong>creased risk of several<br />

<strong>pregnancy</strong> complications <strong>in</strong> overweight or obese women 1<br />

Screen<strong>in</strong>g for gestational diabetes should be considered dur<strong>in</strong>g the first trimester, and later <strong>in</strong> <strong>pregnancy</strong><br />

if the <strong>in</strong>itial screen is negative22 ACOG RECOMMENDATIONS<br />

Recommendations for obese women who are pregnant or plann<strong>in</strong>g a <strong>pregnancy</strong> <strong>in</strong>clude:<br />

5<br />

Preconception counsel<strong>in</strong>g<br />

Thursday, December 06, 2012<br />

Provision of specific <strong>in</strong>formation concern<strong>in</strong>g the maternal and fetal risks of obesity <strong>in</strong> <strong>pregnancy</strong><br />

Consideration of screen<strong>in</strong>g for gestational diabetes upon presentation of <strong>in</strong> the first trimester, and<br />

repeated screen<strong>in</strong>g later <strong>in</strong> <strong>pregnancy</strong> if results are <strong>in</strong>itially negative.


Assessment and possible supplementation of vitam<strong>in</strong> B12, folate, iron, and calcium for women who have<br />

undergone bariatric surgery<br />

Possible use of graduated compression stock<strong>in</strong>gs, hydration, and early mobilization dur<strong>in</strong>g and after<br />

cesarean delivery<br />

Anesthesiology consult (prior to delivery date if possible)<br />

Cont<strong>in</strong>uation of nutrition counsel<strong>in</strong>g and exercise program after delivery, and consultation with weight<br />

loss specialists before attempt<strong>in</strong>g another <strong>pregnancy</strong>.<br />

KEY FINDINGS AND RECOMMENDATIONS<br />

Suggested weight ga<strong>in</strong> dur<strong>in</strong>g <strong>pregnancy</strong> varies based on BMI prior to conception<br />

<strong>Obesity</strong> <strong>in</strong> <strong>pregnancy</strong> is correlated with a number of possible complications for both the mother and<br />

child, and these complications tend to <strong>in</strong>crease with the severity of obesity <strong>in</strong> the mother.<br />

Diet modification is very important, before, dur<strong>in</strong>g, and after <strong>pregnancy</strong>, to ensure the best obstetric<br />

outcome<br />

Regular exercise is very important to lower<strong>in</strong>g the risk of many obesity related <strong>pregnancy</strong> complications<br />

Bariatric surgery does not exclude women from be<strong>in</strong>g able to become pregnant, and if enough time is<br />

allowed, can dramatically decrease the risk for obesity related <strong>pregnancy</strong> complications<br />

<strong>Obesity</strong> <strong>in</strong> <strong>pregnancy</strong> can lead to extensive use of health care resources, and primary prevention through<br />

preconception weight loss could significantly reduce the resource use and health care cost.<br />

Complication possibilities should be discussed with potential obese mothers as early as possible, prior to<br />

conception ideally.<br />

For the most up-to-date recommendations, please see the 2009 report from the National Institute of<br />

Medic<strong>in</strong>e.<br />

REFERENCES<br />

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* Image courtesy of http://www.bebemagico.com/wp-content/uploads/2010/06/obesity-and-<strong>pregnancy</strong>.jpg<br />

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3. National Heart, Lung, and Blood Institute (NHLBI) and National Institute for Diabetes amd Digestive and<br />

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6. March of Dimes: www.marchofdimes.com<br />

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6


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