UPCID Research Studies, Updated August 2011

UPCID Research Studies, Updated August 2011
Status Project Title Study design Number of participants Publications
HHV-8: Natural History, Epidemiology, and Pathogenesis
Completed Human Herpesvirus-8 Replication Observational 84 participants enrolled Johnston C, Orem J, Okuku F et al.
studies In A Hyper-Endemic Region
Impact of HIV Infection and Kaposi
Sarcoma on Human Herpesvirus-8
Mucosal Replication and
Dissemination in Uganda. PLoS One
2009;4:e4222
Natural History of HHV-8
Observational 305 participants
Pending
Replication
enrolled
Role of Nutrition in Control of Observational 64 participants enrolled Pending
Chronic Infection and Malignancy study (KOBS
nutritional
substudy)
Pilot/phase 1 Enrolled in the Ready- Pending
randomized to-Use Food trial: 32
controlled
trial (Readyto-Use
Food
trial)
participants enrolled
RCT of Fish Oil Supplementation Pilot/phase 1 68 participants to be Pending
for Control of HHV-8 Replication randomized
controlled
trial
enrolled
Studies in Integrated Genomics and
Observational Not applicable (same Submitted, in review.
progress Proteomics for Discovery of KS (use of participants as KOBS
Biomarkers and Pathogenesis specimens
collected via
the KOBS
cohort)
study cohort )
Primary Infection with Human Observational 29 mother-infant pairs, Pending
Herpesvirus 8
including syblings, were
followed for some
period of time after
delivery of newborn
Immunogenetics of HHV-8
Observational To be enrolled: Up to 70 Pending
Replication
families (4 participants
per family, or 280
participants altogether);
some participants may
be drawn from the
existing cohort of 75
while others may be de
novo
Impact of HIV Infection and
Observational To be enrolled: Up to Pending
Treatment on HHV-8
350 participants
Proposed
studies
EBV / Burkitt Lymphoma
Proposed
studies
HSV
Studies in
progress
Protease-Inhibitor Based HAART
for the Suppression of HHV-8
Viremia and Prevention of Kaposi
Sarcoma
Observational studies of viral
pathogenesis and host control of
HHV-8 infection
Efficacy of lenalidomide for the
treatment of endemic Burkitt
lymphoma
Frequent Assessment of
Asymptomatic HSV-2 Shedding
Among Ugandans
Observational To be enrolled: Up to
252 participants
Observational To be enrolled: Up to
160 participants (up to
30 co-enrolled in
another study)
Phase 2 trial To be enrolled: Up to 52
participants
Observational To be enrolled: Up to
100 participants
Pending
Pending
Pending
Pending

UPCID Research Studies, Updated August 2011
Cancer Epidemiology
Completed
studies
HIV Infection and Survival among
Patients with Non-Hodgkins
Lymphoma in Uganda
Prognosis of AIDS-Associated
Kaposi sarcoma in a Hyperendemic
region
In progress Impact of HIV Infection on Survival
after Diagnosis of AIDS-Defining
and Non-AIDS Defining
Malignancies in Uganda
Proposed
studies
Proposed
studies
Burkitt Lymphoma Genome
Sequencing Project
Identification of Pathogens and
Pathways in the Etiology of Cancer
from Africa
Chart review
study
Chart review
study
Chart review
study
Records for 160
patients with NHL were
reviewed
Records for 114 adult
patients and 73
pediatric patients with a
diagnosis of Kaposi
sarcoma were reviewed
No enrollments; up to
1,900 charts of adult
patients to be reviewed.
Up to 600 charts of
pediatric patients to be
reviewed.
Phase 1 To be enrolled: Up to 80
ppts.
Observational To be enrolled: Up to
150 participants
Bateganya MH, Stanaway J,
Brentlinger PE et al. Predictors of
Survival After a Diagnosis of Non-
Hodgkin Lymphoma in a Resource-
Limited Setting: A Retrospective
Study on the Impact of HIV Infection
and Its Treatment. JAIDS
2011;56;312-319.
Nguyen H, Okuku F, Ssewankambo
F, Magaret A, Johnston C, Wald A,
Kambugu A, Corey L, Orem J, Casper
C. 2009. AIDS-associated Kaposi
sarcoma in Uganda: response to
treatment with highly active
antiretroviral therapy and
chemotherapy. Infectious Agents
and Cancer 4:O5.
Gantt S, Kakuru A, Wald A et al.
Clinical Presentation and Outcome
of Epidemic Kaposi Sarcoma in
Ugandan Children. Pediatr Blood
Cancer 2009;00:1-5.
Phipps W, Ssewankambi F, Nguyen
H et al. Gender Differences in
Clinical Presentation and Outcomes
of Epidemic Kaposi Sarcoma in
Uganda. PLoS One 2010;5:e13936.
Pending
Pending
Pending