discovery - Fred Hutchinson Cancer Research Center

2008 ANNUAL REPORT
paths of
discovery
STOCHASTIC MODELS REVEAL THE SPREAD OF DISEASE IN A PANDEMIC OUTBREAK.

pursuing
discovery
Fred Hutchinson Cancer Research
FRONT COVER: DRESSED IN BRIGHT RED, THE TWO X CHROMOSOMES OF A FEMALE CELL
Center’s scientists weave interdisciplinary
paths to nurture collaboration and
insight. Their scientific endeavors are
long and intense, with no shortcuts or
guarantees. Fueled by their passion for
treatments that offer healing and
for life
IN A MALE PANCREAS (CENTER LEFT) REVEAL THE PHENOMENON OF MOTHER-CHILD CELL EXCHANGE.
for preventive steps
to circumvent the
devastation of cancer,
HIV/AIDS and related diseases, they
seek answers in the population and at
the molecular level. Our researchers
strive for breakthrough moments of
discovery—discovery for life.
Table of Contents
Message from the
President and Director 2
Message from the
Chair of the Board of Trustees 3
Research 4
Donors 19
Financial Summary 24
Center Boards 26
Center Leadership 27

2
Message from the
President and Director
Dr. Lee Hartwell
President and Director
PATHS OF DISCOVERY
The Hutchinson Center has become one of the world’s premier
research institutions thanks to our scientists who have grappled
with some of the most challenging questions in the biosciences, and our
staff who help bring ideas to fruition.
Over the years, the Center’s researchers have refined treatments for
leukemia, lymphoma and other blood diseases. As they have sought to
boost survival rates for once-fatal cancers, their research naturally has
led into new and unexpected directions.
Today, the Center remains a world leader in cancer research, but we
have also expanded our work into other areas, breaking new ground in
HIV/AIDS research and other life-threatening diseases.
Consider the research of some of our featured scientists in this annual report. Dr. Richard Nash, an
oncologist and specialist in leukemia, hopes that what we have learned from blood cancers and their
treatment may some day help people with autoimmune diseases such as systemic and multiple sclerosis.
Dr. Stan Riddell studies autoimmune responses to disease and the role our own T-cells play in fighting
cancer. Stan wants to boost the power of the immune system with better defenses by engineering a special
kind of T-cell so that it targets tumors more successfully.
Dr. Anne McTiernan’s work has focused international attention on the Center. As a cancer prevention
researcher, Anne’s detailed studies are showing us how exercise and diet could help reduce many cancers
that are caused by obesity and sedentary lifestyles.
These scientists are examples of the exceptional team of researchers here at the Hutchinson Center,
people whose passion for their work keeps us focused on the future. With your support, we can ensure
that their innovative work stays on the path of discovery.
Message from the Chair
of the Board of Trustees
If you have ever faced a life-threatening diagnosis, or watched a family
member, friend or colleague duel cancer, HIV/AIDS or a related
disease, you understand why the scientists at Fred Hutchinson Cancer
Research Center are working tirelessly to save lives.
Compassion for you and your loved ones is what drives Hutchinson
Center scientists and staff to seek a better future.
As you will learn in this annual report, this is an exciting time for
scientific research. Technology is playing an increasingly important role
in accelerating the pace of discovery —from Drs. Malik and Emerman
using computers to explore an ancient retrovirus to
Drs. Halloran and Longini using statistical models to study the spread of infectious diseases. The
scientists in this report represent the Center’s host of talented investigators, all of whom are seeking
answers to challenging questions in daring, new ways. In pursuing the paths of their discoveries, our
scientists follow the mission of the Center to eliminate cancer and related diseases.
Contributions like yours are essential to helping the Hutchinson Center sustain our world-class
research environment and fund these discoveries. Private donations play an instrumental role in the
Center’s ability to remain at the forefront of biomedical research by supporting innovative research that
often cannot be funded by government grants alone.
Thank you for sharing my commitment to improving and saving lives and furthering innovative
research at Fred Hutchinson Cancer Research Center.
Sally G. Narodick
Chair, Board of Trustees
SUPPORTING DISCOVERY
3

4
Michael Emerman, Ph.D.
Harmit Malik, Ph.D.
Biologists
U N D E R S T A N D I N G H I V B Y D E L V I N G D E E P L Y
INTO OUR EVOLUTIONARY PAST
When we think about deadly viruses, evolutionary biologist
Dr. Harmit Malik explains, we need to understand that
their complexity and ferocity has been bred through tens of
millions of years of tugging and pulling against the human race.
“In this genetic conflict, either the host is winning or the
virus is winning,” Malik said, pointing to the roughly 8 percent
of the human genome that is made up of old retroviruses that
we carry inside of us like bits of shrapnel from ancient wars.
Today, we face HIV. It crossed
over from chimpanzees to humans
within the last 100 years, so far killing
25 million people and infecting
twice that many. Why does it kill us
and not chimpanzees, which are easily
infected by HIV but not sickened
by it?
Malik and Dr. Michael Emerman,
a molecular biologist, have pondered
such questions for a long time. Most
recently, their collaboration has
yielded important insights into the
evolutionary struggle between viruses and humans. Ultimately,
they hope their research may lead to new drugs to fight HIV.
In one of their most startling collaborations, their labs used
the power of modern computers and DNA technology to
assemble a new version of an extinct retrovirus known as
Pan troglodytes endogenous retrovirus (PtERV), which infected
chimps and gorillas—but not humans—4 million years ago.
By reassembling the retrovirus in such a way that it could
reproduce only once, Malik and Emerman found that a
human protein known as TRIM5α easily defeated PtERV.
Every primate has a version of the TRIM5α protein. In the
rhesus monkey, for example, it kills HIV.
Malik and Emerman also modified the human TRIM5α
protein to resemble a version present in the ancestors of
humans, chimpanzees and gorillas, and found that it no longer
protected against the PtERV.
By modifying TRIM5α, they
also discovered that one version
protected against HIV but not
PtERV. In another modification,
it did the opposite.
Such polar opposites, they
agree, are the result of evolution.
Because our TRIM5α
protein evolved to fight other
retroviruses, it likely left us
vulnerable to HIV, they say.
Is it possible to reproduce a
drug that behaves like a chimp’s TRIM5α does against HIV, or
change the human version ever so slightly so it kills HIV? These
are the kinds of challenges that Emerman and Malik ponder.
The two agree that studying, and in some cases reconstructing,
ancient viruses is not a trivial matter.
In this arms race that’s millions of years old, it pays to
understand the enemy, Malik said.
HIV BREAKS FREE FROM A CONQUERED T-CELL, PREPARED TO INVADE NEW TARGETS.

6
Richard Nash, M.D.
Immunotherapy Researcher/Oncologist
L E U K E M I A T R E A T M E N T S H O W S P R O M I S E
FOR SYSTEMIC AND MULTIPLE SCLEROSIS
As a hard-working member of the immune system, a T-cell
is an efficient killer, attacking anything it perceives as an
intruder, whether it’s a virus-infected cell, a cancer cell or a
bacterium.
But sometimes, a T-cell attacks a friend—and it goes on
attacking, unchecked, destroying healthy tissue and creating
serious autoimmune diseases such as multiple sclerosis and
lupus. Why the immune system goes so
very wrong has puzzled researchers
for decades.
As many as 80 autoimmune diseases
have been identified, and some of
them are capable of causing serious
complications, even death. One
example is systemic sclerosis (also
known as scleroderma), a disease without
effective treatment. “It’s one of the
most frustrating diseases to treat. There’s
high mortality and no therapies, and it
can hit you in so many ways,” said
Dr. Richard Nash.
By training, Nash is an oncologist,
a researcher in leukemia and other blood cancers. But thanks to
a unique and unexpected insight, he’s now applying his knowledge
in whole new ways. Along with colleagues, he is taking the
Hutchinson Center’s pioneering leukemia research and applying
it to other diseases, such as systemic sclerosis and MS.
The standard treatment for leukemia and other blood
cancers is chemotherapy, radiation and transplantation of
bone marrow or blood stem cells. Nash is optimistic the same
approach may now help patients with autoimmune diseases.
It has taken some very unlucky patients—a rare few who
had both leukemia and systemic sclerosis—to uncover a
potential new use for transplantation.
With systemic sclerosis, a patient’s skin becomes very hard,
severely limiting movement. When one
of these patients received a stem cell
transplant for cancer, “we saw evidence
of skin improvement. The treatment
suggested that the fibrosis of the skin
was a reversible condition,” Nash said.
“And it appeared to stabilize
the organs.”
With transplantation, it may be
possible to remove the reactive cells that
are triggering the immune system to
attack the body. Currently, Nash’s lab
is conducting three clinical trials to
evaluate the safety and effectiveness
of high-dose chemotherapy and
stem-cell transplantation for systemic sclerosis and MS.
“For me, that’s part of the excitement of being in this
field … we’re doing something different and helping people,
and learning about potential new therapies. To be successful
in any project, collaboration and teamwork are very
important,” he said.
A BRAIN SCAN SHOWS MULTIPLE SCLEROSIS LESIONS THAT COULD BE IMPROVED WITH T-CELL THERAPY.

J. Lee Nelson, M.D.
Autoimmunity Researcher/Rheumatologist
D E L V I N G I N T O T H E A U T O I M M U N E I M P L I C A T I O N S O F
MOTHER-CHILD CELL SHARING
It feels like a broken bone that never heals, a constant ache.
Pain relievers and powerful steroids may not make a dent in
the excruciating pain. Nor do they relieve the swelling and
stiffness for many rheumatoid arthritis sufferers. But nature
sometimes offers relief: pregnancy. Like a fog lifting, most
pregnant rheumatoid arthritis patients experience life without
constant pain for the first time in years.
Seeing such transformations made Dr. Lee Nelson yearn for
answers. What could make an autoimmune disease like
rheumatoid arthritis turn off? The answer may lie in the
mother-child cell transfer that happens
during pregnancy.
dUsing e lthe vplacenta i n g as a corridor, i n t o some
cells travel between mom and baby, take
up guest residence in their hosts, and
stick around for decades. Nelson and her
interdisciplinary team study this mixing
of genetically distinct individuals, known
as microchimerism, to identify the good
and bad consequences of these foreign
cells in autoimmune diseases, transplantation,
cancer and pregnancy complications.
Nelson, considered one of the world’s leading researchers
in this investigative frontier, has been studying the role that
microchimerism plays in the initiation and remission of autoimmune
diseases since 1986, the year she began her research
career at the Hutchinson Center.
The transferred cells can be found in many human tissues.
They are detected by looking for female cells in a male, or male
cells in a female, or through DNA analysis. The presence of
Y chromosomes in a woman, for example, signifies that
she has acquired cells from a male (most likely from a son
during pregnancy).
Scientists had assumed that a normal immune system would
destroy any maternal cells lingering in a child. That thinking
changed when Nelson and her team found maternal cells
survived decades later in healthy adults. That work
provided evidence for the idea that cells transferred from
mother to fetus are stem cells or related cells, capable of becoming
any type of cell, since stem cells can divide indefinitely.
She also found maternal cells in
the pancreas made insulin, suggesting
they may help regenerate the diseased
organ in diabetics. This finding suggests
that microchimerism might one
day be the crux of new therapies if
the non-native cells could be coaxed
to restore damaged tissues.
“We’re trying to hone in on treatments,”
Nelson said. “I would like to
help alleviate suffering in some way.”
Nelson also conducted the first study to look at microchimerism
in an autoimmune disease. She found evidence for the
involvement of adopted fetal cells in scleroderma (also known
as systemic sclerosis), a life-threatening illness that makes the
skin hard and thick and often attacks internal organs.
Once a lone pioneer in this young field, she said, “This was
an interdisciplinary challenge that people had overlooked, and
it was ripe for important questions and big leaps forward.”
Thanks to Nelson, many of those questions are being answered.
THE EXCHANGE OF MICROCHIMERIC CELLS BETWEEN MOTHER AND CHILD MAY HOLD CLUES FOR AUTOIMMUNE DISEASES.
9

10
Robert Gentleman, Ph.D.
Computational Biologist
S earching
M I N I N G G E N O M I C D A T A F O R C A N C E R ’ S
MOLECULAR SECRETS
for the molecular roots Common of cancer duplicate is akin to reads after biological filtering research. Just a decade ago, scientists could only
looking for the proverbial > needle df1 in lapply(split(df1[, which is where Dr. Robert c("sequence", advances now "count")], enable efficient df1$lane), analysis of half head) a million genes.
Gentleman comes in. Technology $s_1_export.txt
and the need to sift through The new tools enable researchers to uncover novel potential
a deluge of genomic information has transformed biology from targets sequence for therapies count as well as to explore the underlying genetic
a purely lab-based science to an 101 information TAGGACGTGGAATATGGCAAGAAAACTGAAAATCA science as well. causes of many human 243 diseases.
102 GTAGGACGTGGAATATGGCAAGAAAACTGAAAATC 237
Gentleman, head of the Hutchinson Center’s Herbold There has also been an explosion in the amount of informa-
103 GTGGAAAATTTAGAAATGTCCACTGTAGGACGTGG 177
Computational Biology Program, 104creates CCATATTCCACGTCCTACAGTGGACATTTCTAAAT computing tools to tion available about the 165DNA
sequence of the human genome.
analyze massive amounts of data 105 from AGGACGTGGAATATGGCAAGAAAACTGAAAATCAT biological experiments Consequently, researchers 162 have identified a large number of
and uses mathematics and statistics 106 to CATGATTTTCAGTTTTCTTGCCATATTCCACGTCC generate new insights novel genes within these 158previously
unknown sequences. The
incorporating the existing
data. The approach
$s_2_export.txt
sequence count
challenge currently facing
scientists is to find a way to
helps researchers
251 GTAGGACGTGGAATATGGCAAGAAAACTGAAAATC 357 organize and catalog this vast
understand cancer at
its most fundamental
level by illuminating
252 TAGGACGTGGAATATGGCAAGAAAACTGAAAATCA
253 AGGACGTGGAATATGGCAAGAAAACTGAAAATCAT
254 ACTGTAGGACGTGGAATATGGCAAGAAAACTGAAA
255 CATGATTTTCAGTTTTCTTGCCATATTCCACGTCC
324
194
184
160
amount of information into a
usable form.
“Technology drove enor-
which cellular proteins 256 GCCATATTCCACGTCCTACAGTGGACATTTCTAAA 151 mous data sets, which drove
interact and how they
the need for clear, statistical
$s_3_export.txt
work together within a
thinking,” Gentleman said.
sequence count
cell. The process also saves both 401 time GTAGGACGTGGAATATGGCAAGAAAACTGAAAATC and money over other “We have no true comprehension 313 of cancer on a molecular level
lab methods.
402 TAGGACGTGGAATATGGCAAGAAAACTGAAAATCA yet. We need tools to 291 understand how the genome works and
A former auto mechanic might
403
seem
ACTGTAGGACGTGGAATATGGCAAGAAAACTGAAA
like an unlikely we need to know how 235 things interact. If we’re going to go in
404 AGGACGTGGAATATGGCAAGAAAACTGAAAATCAT 205
candidate to become a research
405
scientist.
GTGGAAAATTTAGAAATGTCCACTGTAGGACGTGG
But if you follow and poke something, we better know what the domino effect
188
Gentleman’s path from Hondas 406 to Harvard CTGTAGGACGTGGAATATGGCAAGAAAACTGAAAA to the Hutchinson will be.” 177
Center, his trajectory seems perfectly probable. The former He and his colleagues around the globe collaborate to write
grease monkey has a penchant for
$s_4_export.txt
challenges, so it makes sense free software for the entire scientific community to use. “This is
sequence count
that he’d choose a research endeavor
551 TAGGACGTGGAATATGGCAAGAAAACTGAAAATCA
that’s moving at breakneck a high-risk area, which is not where commercial software goes,”
266
speed. For brilliant young minds, 552biocomputing GTAGGACGTGGAATATGGCAAGAAAACTGAAAATC is the most he said. “We’re only interested 232 in being as close to the edge of
challenging field around. 553 AGGACGTGGAATATGGCAAGAAAACTGAAAATCAT scientific investigation 187 as we can be. We share to learn. Real
Advances in knowledge and
554
technology
ACTGTAGGACGTGGAATATGGCAAGAAAACTGAAA
have transformed change comes from people 164 working well together.”
555 CTGTAGGACGTGGAATATGGCAAGAAAACTGAAAA 161
556 TGTAGGACGTGGAATATGGCAAGAAAACTGAAAAT 139
$s_6_export.txt
sequence count
701 TAGGACGTGGAATATGGCAAGAAAACTGAAAATCA 395
702 GTAGGACGTGGAATATGGCAAGAAAACTGAAAATC 354
703 AGGACGTGGAATATGGCAAGAAAACTGAAAATCAT 263
704UNRAVELING ACTGTAGGACGTGGAATATGGCAAGAAAACTGAAA VAST DNA SEQUENCES, WRITTEN AS A-G-T-C 232 CODES, REQUIRES POWERFUL TOOLS.
5

M. Elizabeth Halloran, M.D., D.Sc.
Ira Longini, Ph.D.
Biostatisticians
PREDICTING THE SPREAD OF INFECTIOUS DISEASES
When the World Health Organization declared smallpox
eradicated in 1980, there was a giddy overconfidence
that the deadly struggle against the microbial world was ending.
“There was this feeling that we had won the battle against
infectious diseases,” said Dr. Elizabeth Halloran, who studied
tropical diseases in the early 1980s, when there was waning
interest in the topic.
Halloran was not convinced microbes had been subdued,
much less conquered. Nor was Dr. Ira Longini, whose travels
through Latin America brought him face to face with tuberculosis,
syphilis and other infectious
diseases that were presumably under
control.
With research funding and drug
development for such diseases in
full retreat at the time, Halloran and
Longini forged paths in the field of
biomathematics and biostatistics to
study the spread of infectious diseases.
Now, as collaborators, they’re among
the world’s leaders in the field, their
expertise sought widely in the struggle
against new and resurgent infectious diseases. During the last
year, they have consulted with federal and state officials and
have been consulted by world health organizations to help
develop intervention plans to control potential pandemics, such
as avian flu.
Today, the threat of a pandemic flu with the potential to
kill tens of millions is a top concern of public health officials
worldwide. HIV, malaria and tuberculosis kill as many as
6 million people each year. Tuberculosis alone is expected to
infect as many as 1 billion people in the next 20 years.
Small as they are, microbes make up 60 percent of the
planet’s biomass. With so many microbes out there, “We’re
EVERY FEW DECADES, THE INFLUENZA VIRUS TRIGGERS MISERY THROUGHOUT THE WORLD.
further away than ever from closing the book on infectious
diseases,” the Infectious Diseases Society of America declared
last year.
It’s within this context that Halloran and Longini collaborate
to create mathematical models that predict the spread of
disease and simulate intervention strategies to save lives.
Using powerful computers to track the potential path of
infectious diseases, the duo believe their mathematical models
could help save the lives of hundreds of millions of people,
particularly against pandemic flu, which unchecked could
spread across the globe in a matter
of months.
Mathematical models allow researchers
to simulate the spread of disease
through different kinds of settings and
test different kinds of intervention. In
one such model, Longini and Halloran
tracked how quickly pandemic flu would
move across the United States if
nothing were done. In a simulated
60 days, the disease had spread to every
corner of the map. The number of dead:
tens of millions. They developed other models to help predict
which interventions—such as vaccination, keeping children out
of schools and asking people to work from home—would most
effectively control spread of the disease and save the most lives.
It’s a scary scenario, but Longini and Halloran believe the
tools are in place to save the world from disaster. And not just
from influenza.
“We hope that the tools we’re developing will be used for all
emerging diseases,” Longini said.
“You can’t control disease but you can intervene to save
lives,” Halloran said. “You can intervene and change the course
of events.’’
13

14
Stanley Riddell, M.D.
Immunotherapy Researcher/Oncologist
CANCER KILLERS WITH STAYING POWER
In a perfect world, cancer doesn’t stand a chance of wreaking
havoc. Like a soldier guarding the home shores, the
immune system gives marching orders to a type of white blood
cell known as T-cells to remain vigilant for an invasion of
foreign cells, including cancerous ones. When a T-cell
recognizes an invader, it initiates a process that targets that cell
for destruction.
But cancer is a formidable foe, one that
Dr. Stanley Riddell is all too familiar with
after more than two decades of waging
war against it. “Tumors are very clever and
they utilize evasion strategies to limit the
effectiveness of the immune response,”
he said.
So he’s fortifying the immune system
with better weapons: long-lived T-cells
specially engineered to seek and destroy
cancer.
Through adoptive T-cell therapy,
Riddell and his fellow researchers
extract white blood cells from a cancer
patient and expose them to proteins made
in abundance by tumor cells. Scientists
then identify the few T-cells that recognize the tumor proteins
and stimulate those to divide, generating a billions-strong
population of cancer-fighting cells that can be infused back into
the patient. Ideally, this unique population of T-cells will find
its way to the tumor site and annihilate the cancer cells.
“When you see it work, it is so amazing—the bone marrow
just goes from being full of leukemia to being in remission and
very large tumors simply melt away,” Riddell said.
T-cells, however, have a fatal flaw. They die quickly. And
if an immune response isn’t sustained, cancer eventually
comes back.
Riddell and his colleagues knew immunity could last a
lifetime—that’s how vaccines work. So the researchers reasoned
that perhaps they were starting with the wrong T-cells.
They began advanced testing on different
types of T-cells and found that one
type—central memory cells—had the
staying power the scientists were seeking.
They now had a sustainable starting point
for cancer immunotherapy: T-cells with the
capacity to survive.
Riddell’s next step involves drawing
blood samples from cancer patients, filtering
out their central memory cells and
engineering those cells with receptors to
target tumors.
The approach holds promise for fighting
different types of leukemia, including
chemotherapy-resistant acute lymphoblastic
leukemia in children, and breast,
ovarian and skin cancers. Riddell’s team’s insights may also
strengthen the work of University of Washington researchers
developing potential breast-cancer vaccines.
“We’re really trying to move immunotherapy with central
memory T-cells into the clinic quickly,” Riddell said. “We are
excited by the potential for success and believe that this therapy
can be applied to several types of cancer.”
T-CELLS SWARM A CANCER CELL.

16
Anne McTiernan, M.D., Ph.D.
Cancer Prevention Researcher
T A K I N G S T E P S T O W A R D C A N C E R P R E V E N T I O N
We all know that exercise is good for us. But what kind
and how much?
As a cancer prevention researcher and pragmatist,
Dr. Anne McTiernan has no illusions about most folks’ commitment
to exercise. She understands that people want to know
exactly what they have to do—and how little they need to
do—to reap healthy rewards.
Thanks to McTiernan’s work, some specific answers now
exist about the role of exercise and weight loss in
reducing the risk of cancer. As director
of the Hutchinson Center’s Prevention
Center—a state-of-the-art facility for
conducting research on exercise and
diet—she designs studies with the aim
of reducing the 25 percent of cancers
caused by excess weight and sedentary
lifestyles.
Fewer than one-quarter of
Americans get minimum daily exercise,
even though regular physical activity
reduces body fat, lowers blood pressure,
cholesterol and the risk of diabetes and
cancer, and improves bone and joint
health, sex drive, sleep and memory.
“We have such an epidemic of
obesity and lack of exercise, which is one reason I’ve gravitated
to exercise and weight control,” McTiernan said. “It’s an area of
study that could have a significant impact.”
Exercise trials are uncommon because they’re expensive and
difficult to fund. McTiernan’s group is the first to specifically
look at the effects increased physical activity and weight loss
have on reducing the chance of getting cancer.
Such risk reduction has been difficult to quantify in the
past, but McTiernan has been able to definitely gauge impacts
by measuring so-called biomarkers in research participants.
Among her most important findings, overweight postmenopausal
women who exercised for 45 minutes five days
a week, whittled away unhealthy belly fat and lowered their
estrogen and testosterone levels, hormones that in excess can
contribute to cancer. In a different study, women who walked
leisurely just one to three hours a week
lowered their risk of dying from breast
cancer by one-quarter compared to
sedentary women; those who walked
three to eight hours weekly cut their
risk in half. Another study showed that
exercise six days a week brought both
sexes significant fat loss and a lowered
risk of colon cancer in men.
McTiernan’s groundbreaking work
has put the Hutchinson Center at the
forefront of the field, earning her an
invitation to join a federal scientific
advisory committee to develop the
nation’s first guidelines to focus on
physical activity—and the first to
recognize the impact of exercise on cancer-risk reduction.
“We’re trying to get specific answers for people: do I need to
lose 50 pounds or will 5 percent of my body weight do it? Will
exercising 20 minutes a day help?” McTiernan said. “Nothing
is guaranteed, but exercise and weight control are like wearing a
seat belt. It reduces your risk.”
EXERCISE AND HEALTHY EATING ARE POWERFUL ANTI-CARCINOGENS.

“THE SEEDS OF
GREAT DISCOVERIES
ARE CONSTANTLY
“THE SEEDS OF GREAT DISCOVERIES ARE CONSTANTLY
FLOATING AROUND, BUT THEY ONLY
FLOATING AROUND, BUT THEY ONLY TAKE ROOT IN
TAKE ROOT IN MINDS
WELL PREPARED
MINDS WELL PREPARED
TO RECEIVE THEM.”
— JOSEPH HENRY
TO RECEIVE THEM.”
A RETROVIRUS’ PATH BECOMES EVIDENT IN AN EVOLUTIONARY TREE.
Donors
PRIVATE CONTRIBUTORS
FISCAL YEAR 2008
Private contributors fund many critical
programs at Fred Hutchinson Cancer
Research Center. During this fiscal year,
individuals, corporations, foundations
and other organizations donated $33.7
million through contributions, memorial
and honor donations, and in-kind gifts.
The following donors contributed $5,000
or more between July 1, 2007, and June
30, 2008. President’s Circle members —
donors who have made contributions of
$10,000 or more in flexible funding — are
indicated by (PC). Charter members
of the President’s Circle are indicated
by (PC*). Corporate Affiliates members—
corporations that have made contributions
of $10,000 or more in flexible funding —
are indicated by (CA).
Nobel Laureates Circle
The Nobel Laureates Circle recognizes
contributors who have made cumulative
gifts of $1 million or more. These key
contributors are permanent members of
the Circle which was established in 2001
to honor the Hutchinson Center’s Nobel
Prize recipients, Drs. E. Donnall Thomas
(1990), Lee Hartwell (2001) and Linda
Buck (2004). By giving at this level,
members of the Nobel Laureates Circle are
at the forefront of philanthropic leadership
and make a significant impact on the
Hutchinson Center’s mission to eliminate
cancer and related diseases as causes of
human suffering and death.
Madeline and Howell E. Adams, Jr.
Mr. Paul G. Allen
American Cancer Society
Amgen Foundation
Anonymous (3)
Robert M. Arnold
Avon Foundation
Bill & Melinda Gates Foundation
Burroughs Wellcome Fund
Canary Foundation
Cell Therapeutics, Inc.
Charles E. Stuart Charitable Foundation
Mylo and Marion Charlston
Damon Runyon Cancer Research
Foundation
David Worthington Garner Trust
Delta Tau Delta Fraternity
Dorothy W. Day Trust
J. Orin and Charlene Edson
Clairmont L. & Evelyn S. Egtvedt
Entertainment Industry Foundation
Erna M. Jorgensen Trust
The Eucalyptus Foundation
Fannie E. Rippel Foundation
Friends of José Carreras
International Leukemia Foundation
Bill and Melinda Gates
Bob and Eileen Gilman Family
The GM Foundation
Calvin A. Gorman Estate
Alice Coulon Hanson
Lee Hartwell and
Theresa Naujack Hartwell
Bob and Pat Herbold
Arthur P. Holm Estate
Howard Hughes Medical Institute
Yvonne Twining Humber Estate
J. Orin Edson Foundation
Jacob Green Charity Golf Classic
James B. Pendleton Charitable Trust
James S. McDonnell Foundation
Nelda Kleinschmidt
Lance Armstrong Foundation
The Leukemia & Lymphoma Society
Listwin Family Foundation
Lucille P. Markey Charitable Trust
M. J. Murdock Charitable Trust
Mr. John A. McCone and
Mrs. Theiline Pigott McCone
Microsoft Corporation
Moneytree, Inc.
The Moyer Foundation
Craig and Marie Mundie
Muscular Dystrophy Association
The Norcliffe Foundation
Dorothy and Everett O’Neill
The Paul G. Allen Family Foundation
Prostate Cancer Foundation
James and Sherry Raisbeck
Richard C. Goldstein Private Foundation
Jim Roberts and Pam Becker
Safeway Inc.
James G. Scripps Estate
The Seattle Foundation
Susan G. Komen for the Cure
Herman E. Tenzler Estate
Dr. and Mrs. E. Donnall Thomas
Mikal and Lynn Thomsen
Hazel Johnson Toly Estate
Bonnie and Jim Towne
United Way of King County
W. M. Keck Foundation
Richard W. Weiland †
The William Randolph
Hearst Foundations
Research Benefactors
$1 million or more
Avon Foundation
Canary Foundation
Entertainment Industry Foundation
The Eucalyptus Foundation
Friends of José Carreras
International Leukemia Foundation
Alice Coulon Hanson
Hutch Holiday Gala
(Grace Heffernan Arnold Guild
and Gala Board of Trustees)
The Leukemia & Lymphoma Society
Listwin Family Foundation
Safeway Inc.
Richard W. Weiland Estate
Research Patrons
$500,000 - $999,999
Anonymous (1)
Peter Jerome Cervenak Estate
Charles E. Stuart Charitable Foundation
Climb to Fight Breast Cancer
(CFBC Committee)
J. Orin and Charlene Edson PC
Bob and Eileen Gilman Family
Bob and Pat Herbold PC*
Susie Morganti PC
The Paul G. Allen Family Foundation
Sam and Betty Lebid Foundation
Research Partners
$250,000 - $499,999
American Cancer Society
Apoptos Inc.
Bill & Melinda Gates Foundation
Damon Runyon Cancer Research
Foundation
Edna Williams Curl Trust
Fate Therapeutics
Giles W. and Elise G. Mead Foundation
Hutch Award Luncheon
(Hutch Award Luncheon Committee)
J. Orin Edson Foundation
James B. Pendleton Charitable Trust
Lance Armstrong Foundation
M. J. Murdock Charitable Trust
Marsha Rivkin Center for
Ovarian Cancer Research
National Marrow Donor Program
Pete Gross House Luncheon
(Pete Gross House Council)
Premier Chefs Dinner (Magnolia Guild
and Chefs Advisory Board)
Doris L. Sather Estate
The Seattle Foundation
Susan G. Komen for the Cure
Mae Sim Thomas Estate
Washington State Department of Health
Wayne D. Kuni and
Joan E. Kuni Foundation
Research Associates
$100,000 - $249,999
American Society of Clinical Oncology
American Society of Hematology
Amgen Foundation
The Anderson Foundation PC*
Burroughs Wellcome Fund
Charles Epstein Trust
The Christopher Harper Trust
Dr. and Mrs. Edmund R. Clarke
Roger and Gloria Crouch PC*
Mike and Karen Dunlop PC*
John and Christine Enslein
Erna M. Jorgensen Trust
Fanconi Anemia Research Fund, Inc.
Fisher Radio Seattle’s AM 570 KVI
Friends of the Hutch
Calvin A. Gorman Estate
The Greater Kansas City
Community Foundation
Howard Hughes Medical Institute
Intel Corporation
Jacob Green Charity Golf Classic
The John C. and Karyl Kay Hughes
Foundation PC*
Thomas “Red” Kelly Estate
Lymphoma Research Foundation
Phoebe P. Marriott Estate
Merck & Co., Inc.
Microsoft Corporation
The Moyer Foundation
Muscular Dystrophy Association
Prostate Cancer Research Institute
Richard C. Goldstein Private Foundation
The Rona Jaffe Foundation PC
Satellite Healthcare
Loretta V. Schossow Estate
John A. Tershin Estate
Mikal and Lynn Thomsen PC*
Travel & Leisure Auction
(Margaret E. Martindale Guild)
United Way of King County
The V Foundation for Cancer Research
W. M. Keck Foundation
Research Fellows
$50,000 - $99,999
American Airlines
American Heart Association
Anonymous (1) PC*
Anonymous (1) PC
The Bayley Family Foundation
David and Joanna Beitel PC*
Todd, Mary and Geary Britton-Simmons
Costco Wholesale Corporation
Cuyamaca Foundation
David Worthington Garner Trust
Delta Tau Delta Fraternity
Dorothy A. Jarosek Trust
Mark and Carolyn Edson PC*
Clairmont L. & Evelyn S. Egtvedt
Employees Community Fund
of the Boeing Company
Fidelity Charitable Gift Fund
Jane B. Folkrod
Edward and Karen Fritzky Family PC*
Florence Galbraith Estate
Genentech, Inc.
David and Patricia Giuliani PC*
Rochelle Greenberg
Mr. David W. Hansen and
Ms. Trish M. King PC*
Francis E. Hart Estate
Inserra Family Foundation
Jeffrey Rosenzweig Foundation for
Pancreatic Cancer Research
Lisa Johnson of Johnson
International Industries PC
Grace M. Kaylor Estate
Mrs. Yvonne Gemmell Keene
KOMO 4 Television
Laird Norton Tyee Trust Company
Linsco Private Ledger
Martin-Fabert Foundation
The Michael Miyauchi Foundation
National Childhood Cancer Foundation
Ocean Spray
19
21

20
Donors
Olympia Guild
Ora Lee A. Anderson Trust
Pancreatic Cancer Action Network
Phi Beta Psi Sorority
Platt Electric CA
Satya and Rao Remala Foundation PC*
The Stack Foundation
Samuel † and Althea Stroum
Suskin Foundation
John T. Toland Estate
University of Washington
Kenneth L. and Evelyn L. Walters PC*
Washington Research Foundation
Yvonne M. Betson Trust
Research Sponsors
$25,000 - $49,999
Alaska Airlines
Anonymous (2) PC*
Anonymous (1) PC
Bank of America Corporation
Bayley Construction CA
Carl and Renée Behnke PC*
Sally Skinner Behnke PC*
Anselmo Belmondo Estate
Leslie Burrows
Cancer Research Institute
Carlyle, Inc.
Children’s Hospital &
Regional Medical Center
Click Wine Group
Community Foundation for
Southwest Washington
Driving for a Cure
Jack and Sheri Edson PC*
Edward Jones
Carol and Karl Ege PC*
Eli Lilly and Company
Elmo Zumwalt III Guild
Mrs. Ruth E. File PC
Cathryn Fortune and John Shimer
Fortune Family Foundation PC*
The Foster Foundation
Alan and Mary Frazier PC*
Frazier Healthcare Ventures
Fred Hutchinson Team Shootout
Grand Chapter of Washington -
Order of the Eastern Star
Erik and Susan Hansen PC*
Mr. and Mrs. John Harnish
Harold & John Steinberg
Memorial Nursing Scholarship
The Helen Hay Whitney Foundation
Alan and Wendy Higginson PC
Fred and Dawn Hines PC*
Mr. and Mrs. Charles Hogan
Human Frontier Science Program
Maxine Isham Estate
Edith G. Iverson Estate
Henry and Mary Ann James PC*
Mr. and Mrs. J. Michael Johnston PC*
David Jones and
Maryanne Tagney-Jones PC*
King County Combined
Federal Campaign
Klingman Open
Mike and Debbie Koss PC*
The Lambeth Family Designated Fund
Laura A. Landro and Richard E. Salomon
Rae and Mark Lembersky PC*
Life Possibilities
Donors
“THERE’S A HUGE LEVEL OF COMMITMENT IN SCIENCE.
YOU DON’T GO HOME JUST BECAUSE IT’S A CERTAIN TIME;
Benito and Carmen Lopez PC*
David Mann and
Ann Thomson Mann PC*
Maxim Group LLC
Mary Jane McElyea Estate
MDRT Foundation
Merrill Lynch, Pierce,
Fenner & Smith, Inc.
Mo-dazz for the Arts
National Breast Cancer Foundation, Inc.
News Talk 710 KIRO
Novartis
Carol-Ann O’Mack and
John Deininger PC*
Mr. and Mrs. Carroll O’Mack PC*
Milton and Ruth Rubin PC*
Russell Investments
Ryan Hill Research Foundation at
Virginia Mason Medical Center
SASCO
Schwab Charitable Fund
George H.J. Shaw
Jack C. Shaw and Wenonah Shaw
Sheldon Manufacturing, Inc.
Frank and Harriet Shrontz PC*
Lorene Spurling Estate
Howard and Cynthia Steinberg
Gregory and Charlene Steinhauer PC*
Jonathan G. Thomason and
Megan L. Thomason PC*
Union Bank of California
Doug and Maggie Walker PC*
Washington State Employee
Combined Fund Drive
Wyner/Stokes Foundation
Yvonne M. Betson Trust –
Jeff and Ethel Maxwell PC*
Mark and Donette Zbikowski PC
Zillow.com
Joseph and Janet Zinn PC*
Research Supporters
$10,000 - $24,999
Charles M. Ackerman and
Barbara Clanton Ackerman
Acme Food Sales, Inc.
Mr. and Mrs. Mike Adair
Alexandria Real Estate Equities, Inc.
American Research &
Management Company
Mr. and Mrs. James K. Anderson, Jr.
Ric and Kaylene AndersonPC* Anonymous (7) PC*
Anonymous (4) PC
Dr. Frederick and Dita AppelbaumPC* Ms. Doree R. Armstrong
Robert M. ArnoldPC Stephen D. ArnoldPC* Athena Partners
The Ayco Charitable Foundation
Peggie F. Nishimura Bain † PC*
Joe and Karyn BarerPC Mrs. and Mr. Angela K. Barrie
Ron and Joan BayleyPC Bell Lumber & Pole
Mr. and Mrs. Jerry J. Belur
Ben Bridge Jeweler
Yahn Bernier and
Beth McCaw
Evva M. Betts Estate
BK Invitational Golf Tournament
Bill and Jeanne Bliss PC
bmi
The Boeing Company
Bonneville Seattle
Mr. and Mrs. Louis L. Borick PC
Cathy Boshaw and Doug Edlund PC*
Edgar and Elisabeth Bottler PC*
Mr. and Mrs. Erik P. Breivik PC*
Sally V. Brotman PC*
Glen A. Buettgenbach PC*
Shari and Frederick Burns PC*
Mr. Gary L. Bylund PC*
CAC Real Estate Management Co., Inc.
Cancer Center for Detection
and Prevention
Cangen Biotechnologies
Mr. Joseph A. Carbone PC
Carlson Family Foundation PC*
Mrs. Cecelia C. Carr PC*
Mr. and Mrs. John H. Case
Celgene
Spencer W. Chaffey Estate
Vibhas and Arundhati Chandorkar PC*
Charles B. See Foundation PC*
Brad and Judy Chase PC*
Dr. and Mrs. Martin A. “Mac” Cheever
Dale Chihuly
Chihuly, Inc.
Mr. Ryan A. Christensen
The Church of Jesus Christ of
Latter-Day Saints Foundation
Citi Global Impact Funding Trust, Inc.
Continental Airlines
Cornerstone Advisors, Inc.
Thomas G. Corrigan Estate
CRAVE
Mr. and Mrs. Thomas J. Cusick III
Dick and Jill Davis
Mr. Steve Davis and Mr. Bob Evans PC
Dr. H. Joachim Deeg and
Mrs. Francoise Deeg-Le Gal
Dick and Chris DiCerchio PC*
Eric and Holly Dillon PC*
The Dolsen Foundation PC*
Mac and Patti Douglas PC
Jan Dulet PC*
Mr. and Mrs. Kevin P. Eagan PC*
Barbara Feasey and Bill Bryant PC*
Fidelity Brokerage Services LLC
Phelps and Christel Fisher
Myrtle I. Forrest Estate
Foss Maritime Company
Mr. Robert Frey
Mrs. E. Peter Garrett
The Geiger Family Foundation PC*
Bruce and Alice Geismar PC*
Gene Juarez Salons & Spa
Mr. and Mrs. Robert L. Gerth PC*
Mr. Miles Gilburne and Ms. Nina Zolt PC
Aaron and Betty Gilman Family
Mr. and Mrs. Wayne C. Gott PC*
Ken and Betsy Greenbaum PC*
Mark Groudine and Cynthia Putnam
Thomas and Jennifer Hanly PC
John and Suzanne Hansen PC
Mr. and Mrs. Mark C. Hansen
Lee Hartwell and
Theresa Naujack Hartwell PC*
Jeff and Candace Havens PC
Hal and Jerry Haynes
Elizabeth Hebert and Donald Guthrie PC*
Conrad Hewitt
The HG Foundation
Mr. and Mrs. Mike Hickey PC*
Pete and Leslie Magid Higgins PC*
Mr. and Mrs. Neal Hooberman
Peter and Margaret Horvitz PC*
Mr. Bradley J. Horwitz
The Horwitz Family
Memorial Foundation PC
Mr. Norman E. Hubbard and
Ms. Lynne Thompson PC
The Hutchinson Family PC*
The Ildhuso Family PC*
Infinity Pharmaceuticals
Mr. and Mrs. Chris R. Ishii PC*
Jeremy and Jacquelyn Jaech PC*
Mrs. Kristen Jarvis
Jean E. Thomson Foundation PC*
Jewish Community Foundation
of Greater Hartford
Mike and Diane Johansson PC*
John L. Scott Real Estate
John M. Gilbertson Foundation
John R. and Paula Blood Family Trust
Arnold Kas PC*
Donna Kelly
Kenneth and Dorothy L. Anderson
Family Foundation
Keyes Foundation PC*
King County Employee
Charitable Campaign
The Kinsman Foundation
Nelda Kleinschmidt
KMS Financial Service
James and Lorna Kneeland
Reg and Ann Koehler PC*
Judy Kornell
Jackie and Skip Kotkins PC*
Mrs. Frederick Kullman
Mr. and Mrs. Roger W. Kuula PC*
Sandra L. La Haye PC*
Lane Powell PC CA
Lehman Brothers
The Lester and Bernice Smith
Foundation PC*
Jim and Maureen Lico PC
The Louis L. Borick Foundation PC*
Dan Madsen and Amanda King
Mark and Nikki Mahan PC*
Mandarin Oriental, New York
David and Nathan
Mandelbaum Family PC*
Mariners Care
Mattaini Family Foundation PC*
Matthews Cellars
Bev and Jim Mauser
Trish and Peter May
John and Liz McAdam PC*
Rob and Teddy McGregor PC
Mikimoto Co. Ltd.
Rick and Joyce Miner PC
Mr. and Mrs. Michael J. Mitrovich
Monterey Fund, Inc.
Mr. and Mrs. Thomas G. Mormino
Joan Morse and Dean Hachamovitch PC
Karen and Jamie Moyer PC*
Muckleshoot Indian Tribe PC
Shan and Lee Mullin PC*
Kit and Sally Narodick PC*
Paul and Carol Neiman
Robert Nelsen and Ellyn Hennecke PC*
Martin and Vicki Nelson PC*
Nintendo of America Inc.
Northern Trust
Northern Trust Bank, FSB
NSB Postech
Lee and Deborah Oatey
Mr. Bruce A. Oberg
Mr. and Mrs. James Odom
Osiris Therapeutics, Inc.
PDL Biopharma, Inc.
Harry Jonathan Pearce PC*
Ms. Pamela S. Pearson and
Mr. Michael Voegtlin
Mark and Nancy Pellegrino PC*
Pete and Wilma Olsen Foundation PC*
Donald and Diane Peterson PC*
Pfizer Inc.
John B. Piacentini Family PC*
Paul and Beth Picardo PC*
Dean and Gwenn Polik and
Valerie Polack PC*
Arlen and Debra Prentice PC*
The Pride Foundation
Proteolix, Inc.
Puget Sound Energy
Bruce and Celia Pym PC*
P. S. Radhakrishnan
Alexandra Rector
Residence Inn by Marriott -
Seattle Downtown/Lake Union
Jim Roberts and Pam Becker PC*
Ronald D. and Joan A. Roberts PC
Mrs. R. Elaine Robinson PC
Mr. Tom Robinson and
Ms. Carla Murray PC
Roke Foundation
Michael B. Rubin and Sharon K. Birzer
Jon and Judy Runstad PC*
Sajasa Construction, Inc. CA
Don E. Sandberg Estate
Sandberg Northwest Volvo
Savings & Finance Commercial
Bank Limited
Scandinavian Airlines
Schnitzer Investment Corp.
Keith and Jennifer Schorsch PC*
Jim and Bet Schuler
Schwartz Brothers Restaurants CA
Seattle Cancer Care Alliance
Bill and Marlene Semple PC*
The Sign of the Orz
Jim and Jan Sinegal PC*
Singapore Airlines
SiRAS.com
Nate and Luanne Skow PC
Mr. and Mrs. Philip M. Smart, Jr.
Mr. and Mrs. Steven Smith PC*
Sound Community Bank/Laurie Stewart
Doug and Marilyn Southern PC*
Sports Radio 950 KJR
Tom and Diane St. John PC*
Michael and Debbie Stein PC*
Allyn Stellmacher and Terry Samilson PC
John and Sherry Stilin PC
Cynthia Stroum PC*
The Stroum Family Foundation
Symetra Financial
Dr. and Mrs. E. Donnall Thomas PC*
Thrasher Koffey Foundation
Bonnie and Jim Towne PC*
YOU GO HOME WHEN YOUR RESEARCH IS THE BEST IT CAN BE.”
Turner Construction Company CA
United Jewish Foundation of
Metropolitan Detroit
University Mechanical Contractors, Inc.
Tom and Margo Van Halm PC*
Van Sloun Foundation
Neil and Sylvia Van Sloun PC*
Lawrence Votta and Maria Martinez
W Real Estate Services
Hans and Anne Marie Wachtmeister PC*
Shannon and Lucy Wall Estate
Mr. Joseph N. Walter and
Ms. Kathy L. Mares PC
Washington Holdings
Jim and Diane Watson
John W. and Elizabeth Weaver PC
Nancy Weintraub
Nancy L. Wells PC*
Ms. Mary H. Wiese
Doug and Ann Williams PC*
Mr. Donald Williamson PC
The Woldenberg Foundation
Patricia C. Youngman
Melinda Yount PC
Janet and Richard Yulman PC*
Zimmer Gunsul Frasca Architects LLP CA
ZymoGenetics, Inc. CA
Research Friends
$5,000 - $9,999
Aero Controls, Inc.
Affiliated Engineers Inc
Akiko Mikami Shimatsu Foundation
Anonymous (2)
Anthropologie
Mr. and Mrs. Ron R. Bailey
Ballard Technology, Inc.
Betty Banghart
Charles and Linda Barbo
BarclayDean
The Barton Family Foundation
BD Biosciences
Bear Stearns & Co. Inc.
Benaroya Foundation
Ms. Jayme L. Benson
Mr. and Mrs. Bradley J. Berg
Mr. Arnie Bergh
Beta Sigma Phi, Xi Gamma Zeta
The Bishop Family Legacy Foundation
Dr. and Mrs. Joel M. Blumberg
Mr. and Mrs. Peter C. Boal
The Bob Tonkin Memorial Classic
Sandra A. Boeskov
Bonhams & Butterfields
Mabel L. Bonnichsen Estate
Paul and Lynn Bordelon
Mr. and Mrs. Philip Borden
Robert James Bracken Estate
Mr. and Mrs. Mark S. Britton
Mr. James Brownrigg
Builders Financial Services LLC
Fred and Joan Burnstead
CAC Group
Mr. and Mrs. Bob Carr
Dr. Bruce L. A. Carter and
Ms. Jean Enersen
Cathay Pacific
Madam Ho Ching
Robert Christiansen
Clovis Foundation
Roger and Kimberly Collins
Combined Federal Campaign
Kitsap-Mason Counties
Eva Corets and Josh Beloff
Larry and Vickie Culver
Mr. and Mrs. Michael L. Darland
Mr. and Mrs. Matthew J. Deines
Delta Dental Washington Dental Service
Mr. and Mrs. Eugene W. Devlin
Mr. and Mrs. Donald A. Dick
Larry and Gayle Dickenson
The Diffenbaugh Foundation
Mr. and Mrs. John D. Diffenbaugh
Direct Resources Group, Inc.
Mr. and Mrs. Matthew J. Doron
Julie Edsforth and Jabe Blumenthal
El Gaucho
Mr. and Mrs. Thomas A. Ellison
Mr. and Mrs. Steven J. Elsoe
Joan Enticknap
Mr. and Mrs. Joseph Faltermeier
Mr. Justin B. Field
Fingerprint Communications, LLC
Fischer Family
Mr. Jim Ford
Mr. Lloyd D. Frink and Ms. Janet Angell
June B. Gasparovich Estate
Mr. John Gebert, Jr.
Genzyme Corporation
Frederick M. Goldberg and
Carolyn Lakewold
Goldman, Sachs & Co.
Roger and Jennifer Grambihler
Grand Foundation
Dr. and Mrs. John W. Green
Mr. Leonard W. Green
Nancy Greenwood Vehrs and Jeff Vehrs
Guy Carpenter & Company, LLC
GW Cadbury Charitable Trust
Mr. Felix R. Harke
Harris myCFO Foundation
Harry and Faye Rosenberg Trust
Mr. and Mrs. O. Peder Haslestad
Ms. Jean S. Heidt
The Hemp Family LLC
Richard and Marilyn Herzberg
Mr. and Mrs. Harold W. Hill
Mr. and Mrs. Richard Holland
Hotel 1000
Mr. and Mrs. Hong B. Huey
Integra Chemical
Interstate Distributor Co.
Mr. and Mrs. Claude A. Ising
The Joby Foundation Inc.
Mr. and Mrs. Jon Jones
Kate Shea Foundation
Mr. and Mrs. Mel Katten
Keith L. Betts and Marian L. Betts Trust
Olive Kerry Estate
KIRO Television
Kitsap Bank
Mr. and Mrs. Tim Kittilsby
Mr. Justin Knight
Carolyn and Kevin Koester
Nora Korg
Kosan Biosciences
KPFF Consulting Engineers
Yvonne P. and Jack Lamey
Mr. and Mrs. Brad Lange
Lease Crutcher Lewis
Mr. James C. Logsdon
Mr. John C. Logsdon
—DR. STANLEY RIDDELL
Mr. Michael A. Logsdon
Lopez, Hodes, Restaino,
Millman and Skikos
Louise H. & Edward R.
Meyer Memorial Trust
MagicHour Films
Jon and Nancy Magnusson
Helen and David Mandley
Joyce E. Marshall Estate
Mr. and Mrs. Mario Mazzola
Bruce and Jolene McCaw
Mark A. and Marna L. McNaughton
MDS Analytical Technologies
Jessica Meisels
Mellon Bank N.A.
Merchant & Gould
Necia G. Miles Estate
Mr. and Mrs. John F. Miller, Jr.
Richard and Kathryn Miyauchi
Mr. and Mrs. R. David Mushen
Karin and Scott Nagel
National Brain Tumor Foundation
NC Machinery Company
Myrtle M. Nelsen Estate
Mr. and Mrs. Eugene K. Neuberger
Mr. and Mrs. Wayne E. Niemuth
North American Management Corp.
North Mason Cancer Crusaders
Pamela B. Katten Memorial
Leukemia Research Foundation
Christopher P. Parios and Susan Wyant
Mr. Paul S. Pariser
Mrs. Terry Pero
Mr. and Mrs. Wayne M. Perry
Elsbeth Pfeiffer
Mr. and Mrs. John M. Pinkerton
Mr. and Mrs. Matt Pool
Mr. and Mrs. Stephen S. Poore
Precor, Inc.
Q13 FOX/MYQ2
James and Sherry Raisbeck
James V. Ramsdell, Jr.
Raymond James & Associates, Inc.
REB Enterprises, Inc.
Mrs. Sally Reiquam
Chad and Carol Richardson
Ms. Lynn Ristig and Mr. Craig Shrontz
Thurston and Catherine Roach
Mr. and Mrs. Henry M. Robinett
Robinett Investment Co., LLC
John McVickar Robinson and
Elizabeth W. Robinson
Nea Lynn Robinson
Mr. and Mrs. Gene E. Roeglin
Rose-Marie and Jack R.
Anderson Foundation
Rowan University
Kimberly Y. Ruhana and
George W. Ruhana
S*Bio
Mrs. Colleen E. Schafer
Mr. and Ms. Alan D. Sclater
Ruth Martens Scott
Seattle Genetics, Inc.
Seattle Seahawks
Seredigm
Ms. Amy E. Shigo
Andrew Short
Mr. and Mrs. Raymond Sich
Siemens Building Technologies, Inc.
Mr. and Mrs. John Skovron
21

22
Donors
Mr. Laurence H. Smead
Ned and Carolyn Snow
Ronald and Angela Souza
Mr. and Mrs. Frank L. and
Esther A. Springer
Stafford Frey Cooper
Laurie Stewart
Ms. Edith S. Sullivan
The Swanson Family
Ms. Myra H. Tanita
Team Photogenic
Mr. and Mrs. Bruce G. Thayer
Mr. and Mrs. Thomas M. Todaro
Mr. and Mrs. Frank J. Tonkin, Jr.
Trident Seafoods Corporation
Gary and Amanda Tucci
Ueland Foundation
United Way of Tri-State
The UPS Foundation
UW Medicine
Mr. Neil R. Wachter
Washington Mutual Foundation
David and Marsha Weil
Michael and Paula Weintraub
Windstar Cruises
Mr. Chuck Wolfe
Christine and William Woodcock
Woods & Associates
Mr. and Mrs. Scott Allan Wroblewski
Mark A. Young and Kelly Johnson
Zaaz, Inc.
Legacy Partners in Research
Legacy Partners in Research are individuals
who support the Hutchinson Center
through a bequest in their will, life income
gift, life insurance, retirement assets or
other planned gifts. As Legacy Partners in
Research, they create a legacy for themselves
and their families and play a pivotal
role in benefiting future generations.
Charles M. Ackerman and
Barbara Clanton Ackerman
Mr. Donald D. Ackley
Dorothy J. Albro
Arleta Rae Allen
June M. Allen
Ms. Chelea Alwine
Jan A. Amen
Alex and Helen Andersen
Ms. Glenda W. Anderson
Glenn and Lois Anderson
Mrs. Grace Anderson
Stuart L. and Karen C. Anderson
Ms. Victoria Andrews
Anonymous (122)
Frederick J. and Jane C. Artz
Robert and Clodagh Ash
Dr. Elizabeth Atwood
N. Faye Bachmeier
Patricia M. Bartlett
Mr. Alfred A. Baston
Thomas P. and I. Georgina Bayley
Ms. Diana Beckers
Barbara M. Bedayan
Rod Belcher
Mr. Will H. Bennett
Mrs. Constance M. Benston
Marc A. Berger
Mrs. Sidonia Berglund
“WHEN RESEARCH DOESN’T TURN OUT THE WAY YOU EXPECT IT TO,
Yahn Bernier and Beth McCaw
Mr. and Mrs. Harry C. Berryman
Henry A. and Marjorie M. Bickel
Sandra Kailes Biller
Ellen O. Blackstone
Sandra A. Boeskov
Barbara A. Bonamy
Christine Borgen
Robert and Sheila Bosanko
Arthur R. and Bernice J. Bowers
Sandra Brentlinger
Elmore G. and Dorcas Brolin
Glen A. Buettgenbach
Mr. and Mrs. Angelo Bulgarelli
Mrs. Jennie K. Burwell
Mr. and Mrs. Jack and Patty Bush
Stephen D. Cameron
Clint and Ruth Cannon
Phillip and Violette Carlson
Mrs. Lucy Carney
Douglas A. Case
Hazel E. Case
Mary E. Cederlund
Cora Chads
Mylo and Marion Charlston
Ms. Barbara Chester
Mr. Lawrence N. Christian
Susan L. Christiansen
Dr. and Mrs. Edmund R. Clarke
Emanuel and Susan Cohen
Mr. Milton M. Cohen
Gladys M. Collins
Bob and Sylvia Cook
Fred Corrado
Mr. Martin J. Costello
Mary Pat Cotty
Mr. and Mrs. Fenwick J. Crane
Roger and Gloria Crouch
Lamont Crumley and
D. Dianne Wilson-Crumley
Margaret Cullor
Mrs. Leah Currie
Daryl Drew Charitable Foundation
Mr. Roy V. De Britz
Joan A. De Bruin
Tillie I. De Leon
Mr. and Mrs. Henry W. and
Frances C. Decker
Lou Denney
Leslie and Deborah Disch
Chris and Viki Parrott Dragich
Wayne D. and Susan E. DuPont
Mr. James P. Dye
Peter S. and Sandra W. Dyer
Mr. and Mrs. Robert L. Ecker
Demerise Eddy
Cecil David Enman and Norma J. Enman
Thomas G. and Kay Nozaki Ewing
June Faralla
Mr. Richard Faulstich
John and Rosemary Fedorochko
Mary Jane Fee
Clifford H. Fiscus
Mrs. Lorraine M. Flanagan
Anton M. and Barbara C. Fleischman
Jane B. Folkrod
Bob and Lanie Franza
Richard and Linda Frasch
Bill and Deryn Fulton
Larry Gahlhoff
Ken and Lisa Geisen
Jane Gerhardt
James D. and Paula J. Gillmore
Eileen Goebel
Richard Goldstein
Ms. Rosemary Goransson
Mr. and Mrs. Wayne C. Gott
Mr. Mark J. Gralia
Ron and Cathy Grant
Mrs. Norman Groudine
John and Ann Guerin
Donald and Pauline Hagan
Ms. Helen Hamilton
Sharla and Don Hamilton
Martha W. Hanscom
Arthur H. Hansen
Alice Coulon Hanson
Mary Alberta Hargrove
Andy and Carol Harris
Mr. and Mrs. Robert Harrower, Jr.
Mrs. Mary E. Harvill
Peder and Theodora Haslestad
John and Roberta Hayes
Hal and Jerry Haynes
Dr. Frederick and Margaret Hazeltine
Patricia and Robert D. Heffernan, Jr.
Mr. and Mrs. Severt S. Hegland, Jr.
Ms. Jean S. Heidt
Mr. and Mrs. David C. Henderson
Ralph and Gail Hendrickson
Gregory and Anne-Marie Henry
Conrad W. Hewitt
Larry and Marcia Hilberg
Mrs. K. L. Hillard
Vivian and Les Houle
Mr. and Mrs. James W. Howard
Barbara Howell
Mr. and Mrs. George C. Hudspeth
Mr. and Mrs. Paul S. Hunter
Floyd and Barbara Hutton
Mr. and Mrs. James G. Hutton
Dr. and Mrs. Gordon L. Imlay
David and Gigi Jack
Douglas L. Jacobs
Dorothy Doyle Johnson
Mr. Douglas B. Johnson
James A. and Holly F. Johnson
Richard P. and Caroline I. Jones
Thomas M. Jones and Judith A. Edwards
Elaine N. Kaald
Ellen Kam
Miyoko Kaneta
Ms. Heidi Kass
Ms. Deborah Kaufman
Brant A. Keeney
James M. and Lavina S. Kemp
Mr. and Mrs. Donald N. Kinkead
Mr. Robert G. Kinney
Mrs. Nelda S. Kleinschmidt
Frederick and Julianne Klippert
Nora Korg
Mr. and Mrs. Gary A. Krape
Mr. and Mrs. David Kremers
Donna L. Kyle
Larry and Linda LaBolle
Mr. William M. and
Dr. Geraldine K. Landis
Mr. and Mrs. Gus Lange
Lolita Lanning
Gloria L. Larkin
E. Margaret Lawrence
Roy and Vel Leonard
FIGURE OUT WHY.
Martha LePrell
Joe and Lyn Lightfoot
Mr. and Mrs. Stephen H. Lindquist
Ralph and Lynda Lipe
Paul S. MacMichael
Mr. Edward E. Maloof
Wilbur C. Mann
Stephanie D. Mapelli
Mr. and Mrs. Robert J. Margulis
Dr. and Mrs. Herbert A. Marra
Hank, Fuchsia and Marcia Martin
Jeff and Ethel Maxwell
Mr. and Mrs. Robert McDaniel
Mrs. Alma L. McDonald
Mary Jane McElyea
Marcia McGreevy-Lewis and
Robert D. Lewis, M.D.
Douglas G. and Ruth J. McKnight
Barbara F. Meehan
Elinor K. Menter
Robert Miller and Marlys Owen-Jones
Mrs. Anne A. Moldrem
Johnny and Susie Morganti
Mrs. Gladys M. Morrison
Mr. and Mrs. James A. Morrison
Judy Mukai
Mr. and Mrs. Al Neelley
Nick and Carol Westlund
Supporting Organization
Miss Elsa Nordin
Mrs. Ella Nuckolls
Everett and Dorothy O’Neill
Mrs. Jean B. O’Neill
Mr. Charles L. O’Shea
Alice Oehler
Carole A. Olson
Miss Elvi M. Olsson
Mr. Stanford E. Opdyke
Robert B. Overhus
Mrs. James Owen
Stanley Ozbolt
Mr. and Mrs. Geoffrey and Netta Page
Kenneth and Lorrayne Palmer
Mr. and Mrs. Jack G. Parks
T. Keith and Janet Patrick
Harry and Katherine Pearce
Kristian Pearson
Frederick and Elizabeth Pedersen
Mary R. Pelan
Daniel J. Peters
George and Cynthia Pierce
Julia B. Poduch
Bradford and Sandra Porter
Deirdre and Dickson Preston
Marietta E. Priebe
Mr. Ross Purintun
Mr. and Mrs. Robert and Teresa Quigley
Gustav and Claire T. Raaum
Sherry Y. Rae
Mrs. Della L. Ramsden
Weldin and Jo Ann Read
Mrs. Sally Reiquam
Bruce and Karen Richards
Douglass and Lea Richter
Mr. and Mrs. Joe A. Riedel, Jr.
Mrs. Margaret Robarge
Marilyn H. Rogers
Claudia Rollins
Mr. and Mrs. Thomas E. Roth
Milton and Ruth Rubin
Mr. and Mrs. Allan N. Rumpf
THAT ANSWER IS USUALLY MUCH MORE INTERESTING THAN IF IT HAD TURNED OUT.”
Mr. Robert H. Rutledge
Cynthia and Gerry Salkowski
Sam and Betty Lebid Foundation
Mary L. Sanderson-Schinman
Patricia L. Schaumberg
Brent and Susan Schlosstein
Loretta Schossow
Ms. Rosalyn H. Schuknecht
Robert E. Schultz
Mr. Casey Sepanski
Dorothy L. Shattuck
Barbara Jean Shenk
Pam and Geoff Sheridan
Pearl L. Shernoff
Mr. C. Larry Shull
Ms. Annette Siversen
Mr. Eugene G. Sivertson
Bernice and George Smith
Mrs. Phyllis H. Smith
Dr. and Mrs. Richard Smith
Ruth B. Smith
Samuel E. and J. Michelle Smith
Joseph T. Smudin
Mr. Frank W. Soderling
Gregory P. Sokolowski
Herba Irene Solstad
Mary and Steve Solum
Mrs. Kathleen P. Spading
Josephine and Stephen Spear
James Speckbrock
Mr. and Mrs. Frank L. and
Esther A. Springer
Mrs. Caren A. Staley
Evelyn Casey Steen
Mrs. Idalene Strang
Janet Swanson
Connie Taylor
Ken and Judy Thomas
Dick and Ruth Thomassen
Mr. and Mrs. Charles M. and
Marjorie J. Thorne
Capt. Donald A. Thornton
Olive Tice
Mr. and Mrs. Michael J. Toennessen
Claribel Trigve
Mr. and Mrs. David T. Troxel
Karl R. and Marcile H. Turner
Mrs. Walter A. Turner
Mr. and Mrs. Robert E. Vallat
Mary C. Vanderzicht
Jean Baur Viereck
Mr. Jerry Warfield
William H. Warner
Jim and Diane Watson
Mrs. Robert E. Weaver
Steve and Dana Weiner
Lewis G. Weiss
Sandra E. Weiss
Catherine and Steven Wells
Anne T. White
Mrs. Edward Whitley
William and Susanna Wiegant
Christopher L. and Ruby D. Wilde
Carl H. Wittenberg
Ms. Dawn M. Wood
Penny M. Woods
Sarah Woods
James and Herma Wyn
Patricia C. Youngman
Mrs. Veva J. Zard
Mrs. Arline Zidell
Inner Circle
The Inner Circle is comprised of current
and former faculty, staff and their spouses;
past and present members of the Board
of Trustees, Board of Ambassadors and
Senior Council and their spouses; as well
as past members of the former Foundation
Board of Directors and their spouses.
It recognizes those who support the
Hutchinson Center through a bequest in
their will, life income gift, life insurance,
retirement assets or other planned gifts.
Steven J. and Lisa M. Anderson
Anonymous (6)
Robert M. Arnold
Rich and Leslie Begert
Carl and Renée Behnke
Sally Skinner Behnke
Brian R. and Shelley J. Buck
William W. and
Kathy Lynn Christoffersen
Mr. and Mrs. John D. Eastham
Karl and Carol Ege
Robert N. and Ingrid Lahti Eisenman
Noemi A. Epstein
Ms. Linda L. Gainer
Janice A. and Robert L. Gerth
Kenneth and Beryl Goodchild
Dr. William Grady and
Dr. Karen Tsuchiya
Sheri Ray Greaves
Marcia and Glenn Harrington
Debra and Chuck Holland
Deborah E. Kirsner
Lynette A. Klein
Reginald S. Koehler III
Judy Kornell
Shelley M. Kuni
Ms. Karen E. Lane
Jerrold D. Liebermann and Linda J. Harris
Jeffrey and Ethel Maxwell
Rachelle A. McCallum
Patricia McCowan
Neil and Nancy McReynolds
Karen and Jamie Moyer
Shan and Lee Mullin
Han and Shawn Nachtrieb
Paul and Carol Neiman
Martin and Vicki Nelson
Dr. Gilbert S. Omenn and
Martha A. Darling
John and Deanna Oppenheimer
Guy and Arlene Ott
John and Jean Rolfe
Michael T. and Nancy A. Ryan
Marilla Satterwhite
Dr. and Mrs. E. Donnall Thomas
Mrs. Barbara Thrasher
Seattle Cancer Care Alliance
The Seattle Cancer Care Alliance (SCCA)
unites the adult and pediatric cancercare
services of Fred Hutchinson Cancer
Research Center, UW Medicine and
Children’s Hospital and Regional Medical
Center. In fiscal year 2008, 1,182 donors
contributed more than $2.1 million to
the SCCA to support efforts to provide
premier, patient-focused care and access to
groundbreaking clinical research to patients
from around the world.
Research Benefactors
$1 million or more
Safeway Inc.
Research Fellows
$50,000 - $99,999
Entertainment Industry Foundation
The Madhouse Project
Seattle Symphony
Thomas C. Wright Foundation
Research Sponsors
$25,000 - $49,999
Fred Hutchinson Cancer Research Center
Lisa Lund Fund
Research Supporters
$10,000 - $24,999
Auburn Regional Medical Center
Broadway Across America/Live Nation
Central Washington Hospital
Children’s Hospital &
Regional Medical Center
Fairfax Hospital
Ms. Catherine L. Fallen
Harrison Medical Center
Highline Medical Center
Legacy Salmon Creek
Perkins Coie LLP
Sacred Heart Medical Center
Seattle Center Marketing
St. Joseph Hospital
St. Joseph Hospital & Medical Center
Virginia Mason Clinic/Medical Center
Yakima Valley Memorial Hospital Center
for Child Health Services
Research Friends
$5,000 - $9,999
Mr. and Mrs. Rajeev Bajaj
Charles B. See Foundation
Mr. Ray Hickey
Holy Family Hospital
Meghan’s Mountain Charitable
Foundation, Inc.
Pacific NW 4 Wheel Drive Association
PeaceHealth Saint John Medical Center
Providence Everett Medical Center
Providence Saint Peter Hospital
Saint Francis Hospital
The Schneider Family Foundation
Mrs. Barbara Stief
United Way of King County
—DR. LEE NELSON
Marsha Rivkin Center for Ovarian
Cancer Research
In partnership with the Hutchinson Center
and Swedish Medical Center, the Marsha
Rivkin Center for Ovarian Cancer Research
is a nonprofit organization dedicated to
saving lives and reducing suffering through
improved treatment, early detection
and prevention of ovarian cancer. The
Rivkin Center funds pilot studies, issues
scientific scholar awards, conducts ovarian
symposiums and provides ovarian-cancer
screening in conjunction with cutting-edge
research projects.
Marsha Rivkin Center Contributors
The following donors contributed
$5,000 or more between January 1 and
December 31, 2007.
$100,000 - $249,999
Bensussen Deutsch & Associates Inc.
Fisher Foundation for Family Health
$50,000 - $99,999
98.9 KWJZ
Janet L. Brown Estate
$25,000 - $49,999
Chuck and Karen Lytle
$10,000 - $24,999
Anonymous (1)
Donna R. Benaroya
Eric and Gloria Bensussen
Bob Bridge Toyota
Ms. Lynda M. Gilman
KING 5 Television
Ladies Auxiliary VFW
The Lester & Bernice Smith Foundation
Martin-Fabert Foundation
David and Mette Naness
Swedish Medical Center First Hill Auxiliary
$5,000 - $9,999
Mr. and Mrs. Wayne Anderson
Apple American Group
Athena Partners
Bank of America
Cell Therapeutics,
Drs. James and Sue Bianco
Mr. Mark J. Craemer
Grandmasters, LLC
Mr. Luther Haugan
Health Care Property Investors, Inc
Mr. David A. Hoffman
Jim and Lorna Kneeland
MaryAnne and Richard Kobylka
Mrs. Lisa Kreissler and Mr. Allen Derheim
Allan B. Learned
Mr. C. Eric Morse
Mr. and Mrs. Paul Russo
The Schuler Family Foundation,
Mr. and Mrs. James K. Schuler
Mr. and Mrs. Frank Sixt
Stuart and Karen Sloan
† Deceased
CA Corporate Affilitates
PC President’s Circle
PC* President’s Circle charter member
23

24
Financial
Summary
OPERATING REVENUES
FISCAL YEAR 2008
n Research Grants and Contracts 78%
n Net Contributions 7%
n Investment Income 4%
n Other Income 11%
OPERATING EXPENSES
FISCAL YEAR 2008
n Program Services– Research 77%
n Facilities and Administration 21%
n Fundraising 2%
Fred Hutchinson Cancer Research Center
Fiscal Years 2008 and 2007
Revenues and Other Support
(in thousands of dollars)
2008
(Unaudited)
2007
(Audited)
Research Grants and Contracts $294,244 $273,621
Net Contributions 27,634 27,669
Investment Income 15,936 20,930
Other Income 43,299 33,990
Total Revenues $381,113 $356,210
Expenses
(in thousands of dollars)
Program Services – Research $286,905 $262,755
Facilities and Administration 77,538 73,061
Fundraising 6,861 5,616
Total Expenses $371,304 $341,432
Change in Net Assets from Operations $ 9,809 $ 14,778
Change in Net Assets from Financing Activities – 19,243 8,592
Total Increase/(Decrease) in Net Assets – 9,434 23,370
Net Assets Balance at Beginning of Year 209,676 186,306
Net Assets Balance at End of Year $200,242 $209,676
Thank you for joining us in our mission to eliminate cancer and related
diseases as causes of suffering and death. Private donations like yours
are essential for allowing Fred Hutchinson Cancer Research Center to
rapidly respond to novel research opportunities that can lead to important
medical breakthroughs.
Financial support from our donors enables us to attract and retain
the world’s top scientists, provide our researchers with state-of-the-art
technology needed to advance their work and launch innovative pilot
projects to explore new ways to eliminate cancer and related diseases.
Private gifts also leverage significant additional investment by allowing
investigators to successfully compete for prestigious foundation grants that
do not cover the full cost of research.
The many accomplishments that keep the Hutchinson Center at
the forefront of biomedical research could not be achieved without your
generous gifts.
SOURCES OF CONTRIBUTIONS
FISCAL YEAR 2008
n Planned Giving 29%
n Principal/Major Gifts 23%
n Foundation Relations 17%
n Annual Giving 12%
n Special Events 10%
n President’s Circle 8%
n Corporate Relations 1%
USES OF CONTRIBUTIONS
FISCAL YEAR 2008
n Direct Research Investments 80%
and Patient Care
n Fundraising Expenses 20%
25

26
Center Boards
FISCAL YEAR 2008
Board of Trustees
Sally G. Narodick, Chair
Douglas W. Walker, Vice Chair
Jeffrey P. Maxwell, Treasurer
Steve Davis, Secretary
Ronald E. Bayley
Richard P. Begert
Edward D. Davila, M.D.
Karl J. Ege
Alan D. Frazier
Robert J. Herbold
Peter A. Horvitz
Henry James
Richard E. Jones
Henry L. Kotkins, Jr.
Don J. Listwin
Gary Locke
Patricia B. May
Joan Ellen Morse
Karen Moyer
Robert T. Nelsen
Martin O. Nelson, Jr.
Charlotte H. Reed
John Thurston Roach
Keith M. Schorsch
Stephen V. Sundborg, S.J.
Douglas E. Williams, Ph.D.
Board of Ambassadors
Richard W. Anderson, Co-chair
Carl G. Behnke, Co-chair
Jean B. Rolfe, Co-chair
Constance M. Anderson
Robert M. Arnold
Robert E. Bayley
Sally S. Behnke
Ronald J. Berenson, M.D.
Deborah L. Bevier
Eric S. Bremner
Fred Brown
Philip K. Bussey
Hugh Chang
William W. Christoffersen
Rudolph F. Crew. Ed.D.
David R. Davis, M.D.
Barbara R. Ells
Phelps K. Fisher
Edward V. Fritzky
Ben J. Gantt, Jr.
Jack M. Geoffroy †
Robert L. Gerth
Denver C. Ginsey
Kenneth J. Goodchild
S. John Goodwin
Slade Gorton
Stephen M. Graham
Kenneth S. Greenbaum
Irving M. Haug
Charles L. Hirsch
Ronald S. Howell
John L. Hutchinson
Jeremy A. Jaech
Julius P. Johnston III
Kay D. Jones
Perrin Kaplan
Reginald S. Koehler III
David C. Lycette
David A. Mann
Patricia A. McDonald
Neil L. McReynolds
J. Shan Mullin
Craig J. Mundie
Amb. Della Newman
Gilbert S. Omenn, M.D., Ph.D.
Admiral William A. Owens
Nancy D. Pellegrino
Bruce M. Pym
Charles E. Riley
H. Jon Runstad
Katherine J. Savitt
Harriet Shrontz
The Honorable
Charles Z. Smith
Alessandra Spencer
Michael A. Stein
Cynthia Stroum
Gerald R. Swanson
Rev. Robert V. Taylor
Bonnie A. Towne
George A. Walker
Mary H. Wiese
Scott F. Wilson
John C. Woodin
Cindy Zehnder
Senior Council
Constance M. Anderson
Robert M. Arnold
Robert E. Bayley
Sally S. Behnke
Deborah L. Bevier
Eric S. Bremner
William W. Christoffersen
Vincent F. Coviello, Jr.
David R. Davis, M.D.
Barbara R. Ells
Phelps K. Fisher
David B. Frohnmayer
Ben J. Gantt, Jr.
Jack M. Geoffroy
Denver C. Ginsey
Slade Gorton
Irving M. Haug
Frank H. Hopkins
John L. Hutchinson
Kay D. Jones
Reginald S. Koehler III
Stanley M. Little, Jr.
David C. Lycette
Patricia A. McDonald
Neil L. McReynolds
J. Shan Mullin
Amb. Della Newman
Gilbert S. Omenn, M.D., Ph.D.
George B. Rathmann, Ph.D.
Charles E. Riley
Jean B. Rolfe
James F. Ryan
Harriet Shrontz
The Honorable
Charles Z. Smith
Cynthia Stroum
Rev. William J. Sullivan, S.J.
Gerald R. Swanson
James G. Talbot
Bonnie A. Towne
George A. Walker
Cindy Zehnder
† Deceased
Center Leadership
Lee Hartwell, Ph.D.
President and Director
Myra Tanita
Executive Vice President and
Chief Operating Officer
Mark Groudine, M.D., Ph.D.
Executive Vice President and
Deputy Director
Frederick Appelbaum, M.D.
Senior Vice President and Director
Clinical Research Division
Barbara Trask, Ph.D.
Senior Vice President and Director
Human Biology Division
James Roberts, M.D., Ph.D.
Senior Vice President and Director
Basic Sciences Division
Ross Prentice, Ph.D.
Senior Vice President and Director
Public Health Sciences Division
Larry Corey, M.D.
Senior Vice President and Co-Director
Vaccine and Infectious
Disease Institute
Scott Rusch
Vice President
Facilities and Operations
Bob Robbins, Ph.D.
Vice President
Information Technology
Janell Baldwin
Vice President
Shared Resources
Han Nachtrieb
Vice President
Human Resources
Doug Shaeffer
Vice President
General Counsel
Ulrich Mueller, Ph.D.
Vice President
Industry Relations and
Technology Transfer
Randy Main
Vice President of Finance
and Chief Financial Officer
Nancy Wells
Vice President
Development
Linda Gainer
Vice President
External Affairs and
Communications
Fred Hutchinson Cancer Research Center
At Fred Hutchinson Cancer Research Center, our interdisciplinary teams of worldrenowned
scientists and humanitarians work together to prevent, diagnose and treat
cancer, HIV/AIDS and related diseases. Our researchers, including three Nobel laureates,
bring a relentless pursuit and passion for health, knowledge and hope to their work and
the world.
With research excellence that spans the full spectrum of cancer research, we are
uniquely qualified not only to discover, but to implement lifesaving breakthroughs.
To achieve our goal of improving human health around the world, our scientists lead studies
in the following areas: Early Detection and Intervention, Immunotherapy, Tumor Research,
Fundamental Research, Leukemia and Lymphoma Research, International Research,
Prevention Research, and Childhood Cancers.
In addition to our groundbreaking research, we also provide a range of support services
for the patients and families who come to the Hutchinson Center for lifesaving treatment.
Programs include the Pete Gross House and Hutch School, Cancer Information Service,
the Long-Term Follow-Up Program as well as the Fred Hutchinson Cancer Research Center
Survivorship Program, part of the LIVESTRONGTM Survivorship Center of Excellence
Network, and the Cancer Prevention Clinic located at the Seattle Cancer Care Alliance.
Annual Report
published by the External Affairs
and Communications Department
Fred Hutchinson Cancer Research Center
PO Box 19024
Seattle, WA 98109-1024
206.667.5000
www.fhcrc.org
© 2008 Fred Hutchinson
Cancer Research Center
Gordon Todd
Editor
Barbara Hoberecht
Art Director
Susie Fitzhugh
Portrait Photographer
Ignacio Lobos
Colleen Steelquist
Writers
Photo credits:
Meghan Mullarky, cover; Ignacio Lobos, page 17;
Dr. Florian Hladik, page 28
Printed on recycled paper
27

dedicated to
a future
HIV HIDES IN A DENDRITIC CELL OF THE GENITAL LINING.
of discovery
“DISCOVERY IS SEEING WHAT EVERYBODY HAS SEEN,
AND THINKING WHAT NOBODY HAS THOUGHT.”
—ALBERT SZENT-GYÖRGYI
THE EXPLORATORY NATURE OF SCIENTIFIC INVESTIGATION IS DISPLAYED IN DR. MICHAEL EMERMAN’S NOTES.
BACK COVER: STOCHASTIC MODELS REVEAL THE SPREAD OF DISEASE IN A PANDEMIC OUTBREAK.

Seattle’s reputation as a leader in high technology and biotechnology and the allure of the region’s
natural beauty attract the world’s best minds to Fred Hutchinson Cancer Research Center.
We draw inspiration from our diverse landscape—from rivers and ocean to mountains and forest.
At the Hutchinson Center, we live and breathe a life of science.
Mail Stop J5-200, PO Box 19024, Seattle, WA 98109-1024 206.667.4399 1.800.279.1618 www.fhcrc.org