The EPI-RET-3 wireless retina implant system is suitable to ... - FBMI
The EPI-RET-3 wireless retina implant system is suitable to ... - FBMI
The EPI-RET-3 wireless retina implant system is suitable to ... - FBMI
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<strong>EPI</strong>-<strong>RET</strong>-3<br />
A Wireless Retina Implant in Human Trial<br />
Dipl.-Ing. Chr<strong>is</strong>tian Koch
Retinit<strong>is</strong> Pigmen<strong>to</strong>sa<br />
Symp<strong>to</strong>ms of Retinit<strong>is</strong> Pigmen<strong>to</strong>sa<br />
Night blindness<br />
Narrowing of the field of sight<br />
Totally blindness (in most cases)<br />
Congenital <strong>retina</strong>l d<strong>is</strong>ease<br />
3,000,000 patients (worldwide)<br />
untreatable<br />
<strong>EPI</strong>-<strong>RET</strong>-3 – A Wireless Retina Implant in Human Trial<br />
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Pigments<br />
Degeneration of Light<br />
Sensitive Cells due <strong>to</strong><br />
Retinit<strong>is</strong> Pigmen<strong>to</strong>sa<br />
Pho<strong>to</strong>recep<strong>to</strong>rs<br />
(Rods and Cones)<br />
Cross Section Through the Retina<br />
Bipolar Cells<br />
Ganglion Cells<br />
Nerve Fibers <strong>to</strong> the Brain<br />
<strong>EPI</strong>-<strong>RET</strong>-3 – A Wireless Retina Implant in Human Trial<br />
Electrode Array<br />
3
Technical Concept<br />
<strong>EPI</strong>-<strong>RET</strong>-3 – A Wireless Retina Implant in Human Trial<br />
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CMOS-<br />
Camera<br />
Retina-Encoder Telemetry Unit<br />
Image sensor<br />
380 x 300 Pixel<br />
Extraocular Components<br />
DSP<br />
PDA<br />
FPGA Transmitter<br />
During the first clinic trials the <strong>retina</strong>-encoder and the camera<br />
were replaced by a PC and a software for pattern generation!<br />
<strong>EPI</strong>-<strong>RET</strong>-3 – A Wireless Retina Implant in Human Trial<br />
Implant<br />
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Receiver coil<br />
Energy und data<br />
transm<strong>is</strong>sion via<br />
inductive coupling.<br />
Telemetry signal<br />
Implant – Functional Diagram<br />
Receiver for power<br />
and data<br />
D + T D<br />
Clock and data<br />
separation<br />
U<br />
T<br />
D<br />
Programmable<br />
current source<br />
<strong>EPI</strong>-<strong>RET</strong>-3 – A Wireless Retina Implant in Human Trial<br />
x,y<br />
Shift reg<strong>is</strong>ter<br />
for current and<br />
electrode selection<br />
Receiver IC Stimula<strong>to</strong>r IC<br />
I<br />
Electrode selection<br />
I<br />
1<br />
...<br />
n<br />
Ganglion cell Retina<br />
Biphasic current pulses<br />
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Fully assembled <strong>retina</strong>l <strong>implant</strong><br />
Implant – Fabrication<br />
Encapsulated <strong>implant</strong> with folded microcoil<br />
<strong>EPI</strong>-<strong>RET</strong>-3 – A Wireless Retina Implant in Human Trial<br />
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Retina Implant in Animal Trial<br />
24 <strong>implant</strong>s successfully <strong>implant</strong>ed and stimulated<br />
One <strong>implant</strong> <strong>is</strong> working for more than one year in a mini-pig<br />
<strong>EPI</strong>-<strong>RET</strong>-3 – A Wireless Retina Implant in Human Trial<br />
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Retina Implant in Human Trial<br />
transmitter unit<br />
tactile I/O unit<br />
Complete stimulation setup<br />
PC with software for<br />
pattern generation<br />
<strong>EPI</strong>-<strong>RET</strong>-3 – A Wireless Retina Implant in Human Trial<br />
recording unit<br />
recording electrodes<br />
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Retina Implant in Human Trial<br />
Recorded stimulation artifact as proof<br />
of <strong>implant</strong> functionality<br />
<strong>EPI</strong>-<strong>RET</strong>-3 – A Wireless Retina Implant in Human Trial<br />
Successful comm<strong>is</strong>sioning<br />
In all 6 patients<br />
Up <strong>to</strong> a transm<strong>is</strong>sion d<strong>is</strong>tance<br />
of 25 mm<br />
Without failure due <strong>to</strong> head or<br />
eye movements<br />
For more than one hour<br />
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Conclusion<br />
<strong>The</strong> <strong>EPI</strong>-<strong>RET</strong>-3 <strong>wireless</strong> <strong>retina</strong> <strong>implant</strong> <strong>system</strong> <strong>is</strong> <strong>suitable</strong> <strong>to</strong> elicit<br />
v<strong>is</strong>ual sensations in legally blind RP patients.<br />
Using micro fabrication and micro assembly techniques a small<br />
and low weight but robust <strong>implant</strong> was designed and fabricated.<br />
<strong>The</strong> <strong>implant</strong>ation surgery <strong>is</strong> feasible and the <strong>implant</strong> <strong>is</strong> well<br />
<strong>to</strong>lerated.<br />
<strong>The</strong> <strong>EPI</strong>-<strong>RET</strong>-3 <strong>wireless</strong> <strong>retina</strong> <strong>implant</strong> <strong>system</strong> <strong>is</strong> the first<br />
<strong>wireless</strong> <strong>retina</strong>l prosthes<strong>is</strong> <strong>implant</strong>ed completely within the eye<br />
without any cable connection crossing the eye’s wall.<br />
<strong>EPI</strong>-<strong>RET</strong>-3 – A Wireless Retina Implant in Human Trial<br />
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Thanks <strong>to</strong>:<br />
Prof. Wilfried Mokwa (IWE1)<br />
Acknowledgement<br />
Prof. Peter Walter, Dr. Gernot Rössler, Dr. Bernd Sellhaus (UK-Aachen)<br />
Michael Görtz, Dr. Ingo Kr<strong>is</strong>ch (FHG-IMS)<br />
Dr. Thomas Laube, Dr. Claudia Brockmann (UK-Essen)<br />
Dr. Arthur Messner, Harald Röthgen (DS-IOL)<br />
Uwe Thomas, Dirk Höhl, Stefan Rein (TREC)<br />
<strong>EPI</strong>-<strong>RET</strong>-3 – A Wireless Retina Implant in Human Trial<br />
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