The effect of ovine placenta extract on mammogenesis, lactogenesis ...
The effect of ovine placenta extract on mammogenesis, lactogenesis ...
The effect of ovine placenta extract on mammogenesis, lactogenesis ...
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Th e eff ect <str<strong>on</strong>g>of</str<strong>on</strong>g> <str<strong>on</strong>g>ovine</str<strong>on</strong>g> <str<strong>on</strong>g>placenta</str<strong>on</strong>g> <str<strong>on</strong>g>extract</str<strong>on</strong>g> <strong>on</strong> <strong>mammogenesis</strong>, <strong>lactogenesis</strong>, and galactopoiesis in sheep<br />
Table 1. Eff ects <str<strong>on</strong>g>of</str<strong>on</strong>g> saline and <str<strong>on</strong>g>ovine</str<strong>on</strong>g> <str<strong>on</strong>g>placenta</str<strong>on</strong>g> <str<strong>on</strong>g>extract</str<strong>on</strong>g>, administered ante partum in ewes, <strong>on</strong> milk yield and udder dimensi<strong>on</strong> parameters.<br />
Parameter<br />
Th e administrati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> the <str<strong>on</strong>g>ovine</str<strong>on</strong>g> <str<strong>on</strong>g>placenta</str<strong>on</strong>g> <str<strong>on</strong>g>extract</str<strong>on</strong>g><br />
to the sheep involved in the experiment was made<br />
without any adverse reacti<strong>on</strong>s or sec<strong>on</strong>dary eff ects,<br />
and no risk towards the animal’s health.<br />
Discussi<strong>on</strong><br />
Th e obtained results suggest a positive eff ect <strong>on</strong><br />
<strong>mammogenesis</strong> in pregnant sheep treated with the<br />
<str<strong>on</strong>g>ovine</str<strong>on</strong>g> <str<strong>on</strong>g>placenta</str<strong>on</strong>g> <str<strong>on</strong>g>extract</str<strong>on</strong>g>. Th is possible positive eff ect<br />
was highlighted by measuring the udder. Th e <str<strong>on</strong>g>ovine</str<strong>on</strong>g><br />
<str<strong>on</strong>g>placenta</str<strong>on</strong>g> <str<strong>on</strong>g>extract</str<strong>on</strong>g> c<strong>on</strong>tains specifi c horm<strong>on</strong>al entities,<br />
such as <str<strong>on</strong>g>placenta</str<strong>on</strong>g>l lactogen horm<strong>on</strong>e, well known for<br />
140<br />
Saline (n = 5)<br />
(Mean ± Standard error)<br />
Ovine <str<strong>on</strong>g>placenta</str<strong>on</strong>g> <str<strong>on</strong>g>extract</str<strong>on</strong>g><br />
(n = 5)<br />
(Mean ± Standard error)<br />
Udder circumference (cm) 51.4 ± 0.5 60 ± 1.09 P < 0.05<br />
Anteroposterior length (cm) 35.2 ± 1.06 40.8 ± 0.58 P < 0.05<br />
Latero-lateral length (cm) 27 ± 0.31 30 ± 0.31 P < 0.05<br />
Daily milk yield/sheep (mL) 200.7 ± 0.77 216.61 ± 1.38 P < 0.05<br />
Table 2. Eff ects <str<strong>on</strong>g>of</str<strong>on</strong>g> saline and <str<strong>on</strong>g>ovine</str<strong>on</strong>g> <str<strong>on</strong>g>placenta</str<strong>on</strong>g> <str<strong>on</strong>g>extract</str<strong>on</strong>g>, administered in lactating ewes, <strong>on</strong> milk yield and major milk c<strong>on</strong>stituents.<br />
Parameter Saline (n = 6)<br />
Ovine <str<strong>on</strong>g>placenta</str<strong>on</strong>g>l<br />
<str<strong>on</strong>g>extract</str<strong>on</strong>g> (n = 6)<br />
Daily milk yield (ml) - 248.8 ± 4.720 284 ± 3.510 P < 0.05<br />
Fat (%)<br />
Protein (%)<br />
Lactose (%)<br />
Day 7 6.72 6.9 -<br />
Day 14 6.43 6.88 P < 0.05<br />
Day 21 6.75 7.2 P < 0.05<br />
Day 7 5.21 7.2 -<br />
Day 14 5.01 5.31 -<br />
Day 21 5.41 5.46 -<br />
Day 7 4.39 3.9 -<br />
Day 14 3.7 4.21 -<br />
Day 21 4.81 4.56 -<br />
its direct implicati<strong>on</strong>s in <strong>mammogenesis</strong> in these<br />
species. It has been proven through in vivo and in<br />
vitro research that the <str<strong>on</strong>g>placenta</str<strong>on</strong>g>l lactogen horm<strong>on</strong>e<br />
is involved in sheep <strong>mammogenesis</strong>. Th is horm<strong>on</strong>e<br />
was noticed in Forsyth’s in vitro research (11) and<br />
Leibovich’s in vivo experiments (2) for its spectacular<br />
eff ects <strong>on</strong> mammary glands development in ewes.<br />
Supplementati<strong>on</strong> with this glycoprotein<br />
preparati<strong>on</strong> yielded intensifi cati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> the development<br />
<str<strong>on</strong>g>of</str<strong>on</strong>g> the udder and, most probably, <str<strong>on</strong>g>of</str<strong>on</strong>g> the mammary<br />
secretor epithelium.<br />
Furthermore, our results indicate a positive<br />
eff ect <strong>on</strong> the milk yield in sheep treated ante<br />
P<br />
P