Front Matter (PDF) - BJA

ANAESTHESIA"*
HAS COME A
LONG WAY... J
...SO HAS
REVERSAL
In recent years, many advances have been made in the
field of anaesthesia, including reversal of residual
neuromuscular blockade.
A. H. Robins has been a major contributor to this area
with Robinul.
As an anticholinergic agent Robinul provides significant
advantages over atropine: less initial tachycardia',
better protection against the peripheral muscarinic
effects of neostigmine 1 , and a better quality of recovery 2 .
At reversal, when administered simultaneously with
neostigmine, Robinul is associated with greater
cardiostability than separate injections 3 .
ROBINUL- NEOSTIGMINE injection contains standard
doses of Robinul and neostigmine in a 1ml ampoule,
provides dependable and convenient reversal of
residual neuromuscular blockade, and contributes
further towards improvements in anaesthesia.
I
GLYCOPYRROLATE
NEOSTIGMINE
NKOSTK.MINK MKTHYLSl LPHATK
Each lml contains Gtycopyrroltte USP 500 micrograms (OSmg) Neostigmine Methyfsulphate BP 2500 micrograms I2.5mg! Mication: Reversa
3t residual non-d«potarittng(comp«1itive) neuromuscular block Oau$»m4AJmmittTWt\on: Intravenous injection Adults and Older Patients 1 2ml 12500 microgfams neostigmine methylsulphaWSOO
rncrogrtfttf gtycopyrroiale to 5000 nucrograms neosugmme iMthylsulphate/1000 micrograms glycapyrrolaiel over a penod of 10-30 seconds Alternatively 0 02rnl/kg 150 microgram
- * • • - - - rrogrems gtycopyrrolate per kg body weight) over a psnod of 10 30 seconds Children 002ml/kg (50 micrograms neostigmine methylsulphate/10 micro
pam gfycopyrrobM ptr kg tMdy wwgfati owtr a period of 10-30 seconds These doses may be repealed if adequate reversal is not achieved Total doses m excess of 2ml are nc
recouwModed. CMtot-MfeaiMr HytmteuithniY to ingredients. Mechanical obstruction of gastrointestinal or urinary tracts Concomitant administration of suKamethomum Sid* ffftcts
Meostigmine induced (muscarinic) side effects - bradycardia, increased oropharyngeat secretions, cardiac dysrhythmias. bronchospasm. increased gasuointesuna< activiiy etc
Glycopyrrolate induced side effects dry mouth, difficult-/ m micturition, cardiac dysrhythmias. disturbances of visual accommodation, inhibition of sweating Prtcjti—t: Use with caution n
aatients with bronchospasm. severe bradycardia. fever, glaucoma, coronary artery disease, congestive heart failure, cardiac dysrhyitimias. hypertension, thyrotowcosis, epilepsy or Paritm
wmsm Use with caution m patients wtth mtestmaf anastomoses. Safety m pregnancyJlactatton has not been established B**tc NHS price CIO 37110 * lml ampoules! Ufal Cm»§»Pf P0^
Padtaft Q»aaMt*s Packs of 10 ampoules fwrtk$t WansatiMi Robtnol Neostigmine Infection can be used when atropine has been used as a pre-operatrve arm-cholmergic Prefac
01OOVOO99 Pi—'m Alfcoriirtoii Wimfcii 86^77/1 fMtnaces 1 Mirakhur RK et al Anaesth Analg 19 81. 60. 557-562 2 Sheref SE Br J Anaesth 1985. 57 IBS 191 3 Mostafa SM
itocevic M Anaesthesia 1984; 39 1207 1213 full Data Sheet available on request from A H.Robins Company Ltd.Sussex Manor Business Park. Gatwick Road, Crawley, West Sussex RH10 ?NH