SYMPOSIA
SYMPOSIA
SYMPOSIA
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Abstracts of the Invited Speakers<br />
References:<br />
1. American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders (4th edn) (DSM-IV). Washington, DC: APA.<br />
2. Van Os J, Bak M, Hanssen M, Bijl RV, de Graaf R, Verdoux H. Cannabis use and psychosis: a longitudinal population-based study. Am J Epidemiol 2002;15:319-327.<br />
3. Makkos Z, Fejes L, Inczedy-Farkas G, Kassai-Farkas A, Faludi G, Lazary J. Clinical characteristics of cannabis-induced schizophrenia spectrum disorder.<br />
Neuropsychopharmacol Hung. 2011 Sep;13(3):127-38.<br />
4. Caspi A, Moffitt TE, Cannon M, McClay J, Murray R, Harrington H, Taylor A, Arseneault L, Williams B, Braithwaite A, Poulton R, Craig IW. Moderation of the effect of<br />
adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O methyltransferase gene: longitudinal evidence of a gene X<br />
environment interaction. Biol Psychiatry 2005; 15;57(10):1117-7.<br />
5. Müller-Vahl KR, Emrich HM. Cannabis and schizophrenia: towards a cannabinoid hypothesis of schizophrenia. Expert Rev Neurother. 2008 Jul;8(7):1037-48. Review.<br />
Bulletin of Clinical Psychopharmacology 2011;21(Suppl. 2):S83-4<br />
Selective serotonin reuptake inhibitors in the treatement of cannabis dependence<br />
Musa Tosun<br />
Istanbul Universit Cerrahpasa Medical Faculty, Department of Psychiatry, İstanbul, Turkey<br />
E-mail: musatosun@hotmail.com<br />
Treatment of cannabis dependence should aim cannabis abstinence and psychosocial support as in general dependency treatment<br />
approach.<br />
The cannabis detoxification of the patient might be achieved by treatment interventions in hospital setting or following up the patient<br />
closely in outpatient setting. In outpatient setting, the regular urinalyses and close monitoring of the patient must be carried out. The<br />
metabolites of the cannabinoids could be detected in urinalysis from 3 days up to 4 weeks following the last use.<br />
Individual, family, and group psychotherapies might be beneficial while supporting the patient. Education is the most important element<br />
for both “abstinence” and “support programs,” as the motivation to quit and not to restart is primarily due to education on the effects and<br />
harmful consequences of cannabis abuse. Tranquilizer drugs might be efficient in short term withdrawal symptoms that might be seen<br />
in cannabis abusers or addicts.<br />
Selective serotonin reuptake inhibitors (SSRIs) as other antidepressant agents may be used in the treatment of depressive patients, who<br />
use cannabis as a self treatment for depression, and in co-morbid depression of cannabis use disorders or in depressive symptoms caused<br />
by cannabis abuse. In addition, SSRIs might also be used in the treatment of cannabis-induced anxiety disorders.<br />
There is growing interest in the use of antidepressants in cannabis abuse because of highly reported depression rates during the<br />
treatment of cannabis abuse or after the cessation. Nevertheless, there is a dearth of knowledge about the treatment of cannabis abuse<br />
with SSRIs. In a double blind placebo controlled study, fluoxetine has been reported to decrease the frequency of cannabis use in alcoholic<br />
patients with depression.<br />
References:<br />
1. Cornelius JR Salloum IM, Haskett RF, Ehler JG, Jarrett PJ, Thase ME, Perel JM. Fluoxetine versus placebo for the marijuana use of depressed alcoholics. Addict Behav.<br />
1999 Jan-Feb;24(1):111-4.<br />
2. Hall W. & Degenhardt L. : Cannabis-Related Disorders. in Kaplan & Sadock’s Comprehensive Textbook of Psychiatry 8th ed. Lippincott Williams & Wilkins,<br />
Philadelphia, 2005. Vol. I: 1211-1220<br />
3. Tosun M. : Alkol ve Diğer Maddeler ile İlişkili Bozukluklar. İ.Ü.Cer.Paş.Tıp Fak. Yayınları, Rektörlük Yay.No: 4215, Fak.Yay.No. 229, İstanbul, 2000 : 96-100.<br />
Bulletin of Clinical Psychopharmacology 2011;21(Suppl. 2):S84<br />
S84 Bulletin of Clinical Psychopharmacology, Vol: 21, Supplement: 2, 2011 - www.psikofarmakoloji.org