SYMPOSIA

Abstracts of the Invited Speakers
References:
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4. Seeman MV. The role of estrogen in schizophrenia. J Psychiatry Neurosci 1996; 21:123-125.
5. Zarrouf FA, Artz S, Griffith J, Sirbu C, Kommor M. Testosterone and depression: systematic review and meta-analysis. J Psychiatr Pract 2009;15:289-305.
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Bulletin of Clinical Psychopharmacology 2011;21(Suppl. 2):S77-8
Insulin and psychiatric disorders
Mesut Cetin
Department of Psychiatry, GATA Haydarpasa Training Hospital, Uskudar, Istanbul, Turkey
E-mail: mesutcetin@yahoo.com
Insulin is a hormone central to regulating carbohydrate and fat metabolism in the body. Insulin also influences other body functions, such
as enhancing acute thermoregulatory and glucoregulatory responses to food intake. It is also a neuropeptide transmitter and enhances
learning and memory.
Hypoglycemia is a lack of sufficient glucose and a scarcity of the sources of glucose, which can dramatically manifest itself with impaired
functioning of the central nervous system and can cause dizziness, speech problems, and even loss of consciousness. While producing
those symptoms, hypoglycemia also provokes a rapid increase in epinephrine secretion, which leads to tremulousness, lightheadedness,
perspiration, anxiety, hunger, nausea, and tachycardia. These symptoms present like a panic attack, suggesting that if hypoglycemia does
provoke anxiety attacks it may be through its action as a nonspecific stressor, perhaps by interacting with an underlying CNS disorder
that predisposes to panic. The fear of hypoglycemia-induced bodily symptoms of arousal has been implicated in the pathogenesis of
both spontaneously occurring and experimentally provoked panic attacks. The fear of bodily symptoms may be a characteristic of panic
disorder and is hypothesized to predict state anxiety and panic frequency during experimentally induced peripheral arousal.
Insulin resistance and metabolic syndrome (MS) have become worldwide problems. MS is a cluster of risk factors associated with
increased risk of cardiovascular diseases and type 2 diabetes. Based on research data from 2004, 40% of adults in Turkey meet the criteria
for diagnosis of metabolic syndrome. The use of certain medications, such as atypical antipsychotics, may increase insulin resistance and
the risk of the metabolic syndrome.
Key words: Insulin, panic disorder, insulin resistance, hypoglycemia, depression
Bulletin of Clinical Psychopharmacology 2011;21(Suppl. 2):S78
[PS-14]
Symposium Title: Clinical course of psychiatric disorders associated with trauma and treatment issues
Trauma and mood disorders
Medine Yazıcı Güleç
Erenkoy Mental Research and Training Hospital, Istanbul, Turkey
E-mail: drmedineyazici@yahoo.com, medineyazici@hotmail.com
There is increasing evidence for the role of adverse childhood experiences in the occurence of mood disorders (MD). A great number of
studies have shown that there is a correlation between MD and parental indifference, neglect and sexual and physical abuse. Angst et
al., in a 20-year longitudinal study, suggested that childhood family issues have a robust correlation with the chronicity of bipolar and
unipolar MD, and adverse childhood experiences give rise to low self-esteem and anxious personality. The presence of childhood trauma
(CT) has found to be associated with increases in rates of substance abuse, early age of onset, rapid cycling, and suicide. There is severe
CT in half (49%) of bipolar MD patients.
S78 Bulletin of Clinical Psychopharmacology, Vol: 21, Supplement: 2, 2011 - www.psikofarmakoloji.org