SYMPOSIA

Abstracts of the Invited Speakers
Studies show that effective treatment significantly improves quality of life (3). Severity of childhood ADHD and treatment significantly
predict the persistence of ADHD into adulthood (5). As previously shown by some research for children and adolescents, stimulant
medications alone did not eliminate the academic achievement deficit of ADHD undergraduates. ADHD patients who were treated with
stimulants were significantly less likely to subsequently develop depressive and anxiety disorders and disruptive behavior and less likely to
repeat a grade compared with participants with ADHD who were not treated. Adolescents with ADHD were also significantly more likely
to be absent during the academic year, and they were over eight times more likely than adolescents without ADHD to drop out of high
school. These findings demonstrate that children with ADHD continue to experience severe academic impairment into high school (10).
Key words: Attention deficit hyperactivity, academic performance, occupation
References:
1. Barkley RA. Major life activity and health outcomes associated with attention-deficit / hyperactivity disorder. J. Clin Psychiatry 2002;63 12:10-15.
2. Weiss G, Hechtman L. Hyperactive Children Grown Up: ADHD in Children, Adolescents, and Adults. New York, NY: Guilford Press; 1993
3. Cheng K, Myers KM, Stubble DE. Attention deficit hyperactivity disorder Child and Adolescent Psychiatry The Essentials Lippincott Williams &Wilkins
4. Biederman J, Mick E, Faraone SV. Age dependent decline of symptoms of attention deficit hyperactivity disorder: Impact of remission definition and symptoms
type. Am J Psychiatry 2000 157:816-818
5. Sadock BJ, Sadock VA. Textbook of Child and Adolescent Psychiatry. 2009 Lippincott Williams &Wilkins
6. Culpaper L, Mattingly G. Challenges in Identifying and Managing Attention-Deficit/Hyperactivity Disorder in Adults in the Primary Care Setting: A Review of the
Literature Prim Care Companion J Clin Psychiatry 2010 v. 12(6);
7. McCann BS, Roy-Byrne P Attention-deficit/hyperactivity disorder and learning disabilities in adults. Semin Clin Neuropsychiatry. 2000 Jul;5(3):191-7.
8. Spetie L, Arnold EL. Attention deficit hyperactivity disorder in Lewis Child and Adolescent Psychiatry A Comprehensive Textbook 2007 Lippincott Williams &Wilkins
9. Lam AK, Ho TP Early adolescent outcome of attention-deficit hyperactivity disorder in a Chinese population: 5-year follow-up study. J Fam Pract. 2011 Jun;60(6):364-7.
10. Kent KM, Pelham WE Jr, Molina BS, Sibley MH, Waschbusch DA, Yu J, Gnagy EM, Biswas A, Babinski DE, Karch KM.The academic experience of male high school
students with ADHD.Pediatrics. 2009 Jul;124(1):71-8.
Bulletin of Clinical Psychopharmacology 2011;21(Suppl. 2):S57-8
[PS-05]
Symposium Title: Brain mapping, TMS, NVS, biofeedback and deep brain stimulation in treatment of psychiatric disorders
Concomitant use of qEEG and rTMS in treatment of depressive disorder, new approaches
Nevzat Tarhan, Gökben Hızlı, Serap Aydın
Üsküdar University, Neuropsychiatry Istanbul Hospital, Istanbul, Turkey
E-mail: ntarhan@uskudar.edu.tr, ntarhan@gmail.com
Repetitive transcranial magnetic stimulation (rTMS) therapy has been approved for treatment of depression by the FDA in 2008, and was
included in APA Guidelines as published in October, 2010 issue of American Journal of Psychiatry. Although its efficacy is not as high as
the efficacy of ECT, rTMS is safer in the treatment of depression in older patients. Especially the absence of common treatment side effects
of ECT, such as confusion and memory problems, makes rTMS treatment more valuable in patients with high side effect risk.
This study was performed by the quantitative EEG (qEEG) monitoring before and after rTMS treatment. The aim was to examine the
predictive value of qEEG as a biological indicator of response to rTMS treatment.
In Neuropsychiatry Istanbul Hospital, between dates of 2006-2010, rTMS had been applied to 1283 patients with a diagnosis of treatmentresistant
depressive disorder. The patients discontinued the psychotropic medications 12 hours before the qEEG monitoring. qEEG records were
taken just before the first and the last rTMS sessions. HAM-D 17 was performed before and after 15-20 (mean was 18) sessions of rTMS treatment.
The patients with a medical history of epilepsy were excluded. The cases with no history of seizures, but with suspicious epileptical
abnormality in pre-treatment EEG were included with special medical caution. rTMS treatment was performed at left DLPFC, as 25 hz. and
1000 pulse, one session on each day, a total of 15-20 sessions, with Magstim Rapid.
From 1283 cases, one patient had epileptic seizure as an adverse effect. Due to contraction of facial muscles, one patient had a broken
tooth. In 3 patients suffering from tinnitus occurred, but later tinnitus decreased significantly.
The statistical analyses of the cases are ongoing. The initial results with remission and response rates will be presented. qEEG power
spectrum changes and changes in the activation compared to normative data base in LORETA will be evaluated.
Key words: Repetitive transcranial magnetic stimulation (rTMS) therapy, quantitative EEG, depression treatment
Bulletin of Clinical Psychopharmacology 2011;21(Suppl. 2):S58
S58 Bulletin of Clinical Psychopharmacology, Vol: 21, Supplement: 2, 2011 - www.psikofarmakoloji.org