SYMPOSIA
SYMPOSIA
SYMPOSIA
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Abstracts of the Invited Speakers<br />
monitoring was required. The implementation of this monitoring system has successfully reduced the incidence of CIA from 1.3% to 0.4%.<br />
Currently 239 cases of agranulocytosis are registered at the FDA adverse drug reaction data bank.<br />
There have been certain attempts to predict agranulocytosis by genetic association studies in particular in the NADPH myeloperoxidase<br />
complex (1) and FC-gamma receptors (2). We could identify an association to the polymorphic myeloperoxidase, responsible for oxidative<br />
reaction in neutrophils. More recently, confirmatory studies in two independent cohorts of 33 and 49 CIA cases and 54 and 78 controls<br />
indicated that markers in the HLA system are highly significantly associated with the risk of CIA. HLA-DQB1 6672G>C was associated with<br />
CIA conferring an odds ratio of 16.9 (3). Currently a large consortium led by Duke University has aimed to collect a large sample of well<br />
defined cases of CIA in order to allow genome-wide association studies.<br />
Key words: Clozapine, agranulocytosis, NADPH-oxidase, myeloperoxidase, HLA-system, genetic association<br />
References:<br />
1. Mosyagin I, Cascorbi I, Schaub R, Krüger T, Dettling M. Drug-induced agranulocytosis: impact of different fcgamma receptor polymorphisms? J Clin<br />
Psychopharmacol. 2005;25:435-40.<br />
2. Mosyagin I, Dettling M, Roots I, Mueller-Oerlinghausen B, Cascorbi I.. Impact of myeloperoxidase and NADPH-oxidase polymorphisms in drug-induced<br />
agranulocytosis. J Clin Psychopharmacol. 2004;24:613-7.<br />
3. Athanasiou MC, Dettling M, Cascorbi I, Mosyagin I, Salisbury BA, Pierz KA, Zou W, Whalen H, Malhotra AK, Lencz T, Gerson SL, Kane JM, Reed CR. Candidate gene<br />
analysis identifies a polymorphism in HLA-DQB1 associated with clozapine-induced agranulocytosis. J Clin Psychiatry. 2011;72:458-63.<br />
Bulletin of Clinical Psychopharmacology 2011;21(Suppl. 2):S45-6<br />
[JS-05]<br />
Indian Psychiatric Society<br />
Symposium title: Current concept of obsessive compulsive disorder (OCD)<br />
Current understanding of the concept of obsessive compulsive disorder<br />
Manickam Thirunavukarasu<br />
Professor & Head, Department of Psychiatry, SRM MC & RC, Kattankulathur, 603203, India<br />
E-mail: arasueshwar@gmail.com<br />
Obsessive-compulsive disorder (OCD) is a relatively common disorder, occurring in around 2-3% of general population. In the past<br />
century, the understanding of the disorder has improved and has been clearly delineated as a valid nosological entity. The heterogeneity<br />
of the disorder has been explained based on various phenotypic subtypes. Factor analytic studies have provided consistent evidence that<br />
distinct obsessive-compulsive symptom dimensions exist, including obsessions/checking, contamination/washing, symmetry/ordering,<br />
and hoarding. It has been hypothesized that each symptom dimension may be underpinned by a distinctive set of bio-behavioral<br />
mechanisms. There has been a good deal of interest recently in the disorders characterised by similar phenomenology and psychobiology<br />
called obsessive compulsive spectrum disorder (OCSD). These include tic disorder, body dysmorphic disorder, impulse control and eating<br />
disorders. In view of all these changes in understanding and newer conceptualisation, OC(S)D might find a separate place for itself in the<br />
DSM V and ICD 11, rather than being classified under anxiety / neurotic spectrum disorders.<br />
Bulletin of Clinical Psychopharmacology 2011;21(Suppl. 2):S46<br />
Biological theories of obsessive compulsive disorder<br />
A. Shyam Sundar<br />
Assistant Professor, Department of Psychiatry, SRM Medical College Hospital and Research Centre, Kattankulathur, 603203, India<br />
E-mail: a.shyamsundar@gmail.com<br />
Although the pathophysiology of OCD is still far from resolved, the existence of a biological basis for OCD has been clearly established.<br />
Twin, family, segregation and linkage studies have demonstrated that genetic factors contribute to the pathogenesis of OCD. There<br />
S46 Bulletin of Clinical Psychopharmacology, Vol: 21, Supplement: 2, 2011 - www.psikofarmakoloji.org