SYMPOSIA

Abstracts of the Invited Speakers
monitoring was required. The implementation of this monitoring system has successfully reduced the incidence of CIA from 1.3% to 0.4%.
Currently 239 cases of agranulocytosis are registered at the FDA adverse drug reaction data bank.
There have been certain attempts to predict agranulocytosis by genetic association studies in particular in the NADPH myeloperoxidase
complex (1) and FC-gamma receptors (2). We could identify an association to the polymorphic myeloperoxidase, responsible for oxidative
reaction in neutrophils. More recently, confirmatory studies in two independent cohorts of 33 and 49 CIA cases and 54 and 78 controls
indicated that markers in the HLA system are highly significantly associated with the risk of CIA. HLA-DQB1 6672G>C was associated with
CIA conferring an odds ratio of 16.9 (3). Currently a large consortium led by Duke University has aimed to collect a large sample of well
defined cases of CIA in order to allow genome-wide association studies.
Key words: Clozapine, agranulocytosis, NADPH-oxidase, myeloperoxidase, HLA-system, genetic association
References:
1. Mosyagin I, Cascorbi I, Schaub R, Krüger T, Dettling M. Drug-induced agranulocytosis: impact of different fcgamma receptor polymorphisms? J Clin
Psychopharmacol. 2005;25:435-40.
2. Mosyagin I, Dettling M, Roots I, Mueller-Oerlinghausen B, Cascorbi I.. Impact of myeloperoxidase and NADPH-oxidase polymorphisms in drug-induced
agranulocytosis. J Clin Psychopharmacol. 2004;24:613-7.
3. Athanasiou MC, Dettling M, Cascorbi I, Mosyagin I, Salisbury BA, Pierz KA, Zou W, Whalen H, Malhotra AK, Lencz T, Gerson SL, Kane JM, Reed CR. Candidate gene
analysis identifies a polymorphism in HLA-DQB1 associated with clozapine-induced agranulocytosis. J Clin Psychiatry. 2011;72:458-63.
Bulletin of Clinical Psychopharmacology 2011;21(Suppl. 2):S45-6
[JS-05]
Indian Psychiatric Society
Symposium title: Current concept of obsessive compulsive disorder (OCD)
Current understanding of the concept of obsessive compulsive disorder
Manickam Thirunavukarasu
Professor & Head, Department of Psychiatry, SRM MC & RC, Kattankulathur, 603203, India
E-mail: arasueshwar@gmail.com
Obsessive-compulsive disorder (OCD) is a relatively common disorder, occurring in around 2-3% of general population. In the past
century, the understanding of the disorder has improved and has been clearly delineated as a valid nosological entity. The heterogeneity
of the disorder has been explained based on various phenotypic subtypes. Factor analytic studies have provided consistent evidence that
distinct obsessive-compulsive symptom dimensions exist, including obsessions/checking, contamination/washing, symmetry/ordering,
and hoarding. It has been hypothesized that each symptom dimension may be underpinned by a distinctive set of bio-behavioral
mechanisms. There has been a good deal of interest recently in the disorders characterised by similar phenomenology and psychobiology
called obsessive compulsive spectrum disorder (OCSD). These include tic disorder, body dysmorphic disorder, impulse control and eating
disorders. In view of all these changes in understanding and newer conceptualisation, OC(S)D might find a separate place for itself in the
DSM V and ICD 11, rather than being classified under anxiety / neurotic spectrum disorders.
Bulletin of Clinical Psychopharmacology 2011;21(Suppl. 2):S46
Biological theories of obsessive compulsive disorder
A. Shyam Sundar
Assistant Professor, Department of Psychiatry, SRM Medical College Hospital and Research Centre, Kattankulathur, 603203, India
E-mail: a.shyamsundar@gmail.com
Although the pathophysiology of OCD is still far from resolved, the existence of a biological basis for OCD has been clearly established.
Twin, family, segregation and linkage studies have demonstrated that genetic factors contribute to the pathogenesis of OCD. There
S46 Bulletin of Clinical Psychopharmacology, Vol: 21, Supplement: 2, 2011 - www.psikofarmakoloji.org