SYMPOSIA

Poster Presentations
of action, amisulpride might be the drug of choice in tic disorders. On the other hand, larger controlled clinical trials should be planned
on this issue.
Key words: Tic disorders, echopraxia, amisulpride, side effect
References:
1. Turan M, Çilli AS. Tik bozuklukları. Genel Tıp Derg. 1999;9(3):117-21
2. Fountoulakis KN, Lacovides A, Kaprinis GS. Successful treatment of Tourette’s disorder with amisulpride, Ann Pharmacother. 2004; 3: 901.
3. Leysen JE, Janssen PMF, Heylen L, Gommeren W, Van Gompel P, Lesage As.Receptor interactions of new antipsychotics: relation to pharmacodynamic and clinical
effects. Int J Psychiatry Clin Pract; 1998; 2(Suppl.1): 3-17.
4. Ates MA, Algül A, Semiz UB, Güneş C, Çetin M. Tedaviye dirençli Gilles de la Tourette sendromunda amisülpirid kullanımı: Bir olgu sunumu. Yeni Sempozyum Dergisi.
2009; 47:1: 16-18.
Bulletin of Clinical Psychopharmacology 2011;21(Suppl. 2):S199-200
[PP-126] Ref. No: 290
Evaluation of patients with obstructive sleep apnea syndrome referred to the sleep
disorders unit of a university hospital
Evrim Özkorumak 1 , Haluk Hıdıroğlu 2 , Ahmet Tiryaki 1 , İsmail Ak 1
1 Karadeniz Technical University, Psychiatry Department, Trabzon, Turkey
2 Ataköy State Mental Health Hospital, Trabzon, Turkey
E-mail: evrimozkorumak@yahoo.com
Introduction: Obstructive sleep apnea syndrome (OSAS) is characterized by repetitive episodes of apnea and hypopnea, and decrease in
oxygen saturation (1). The relationship of OSAS and other medical conditions has been explored in the research literature while the relationship
between OSAS and mental health has not been sufficiently investigated yet. The aim of this study was to determine the distribution of mental
disorders and the type of distribution of mental disorders within clinical features of OSAS from the point of view of psychiatry.
Method: The patients, who were referred to the sleep disorders unit of Karadeniz Technical University, Faculty of Medicine Hospital for
1 year were considered the population for this study. A total of 102 patients, with a diagnosis of OSAS according to polysomnography
and patients with no exclusion criteria composed the sample of the study. The patients were classified according to the ICSD-2 (The
International Classification of Sleep Disorders) with polysomnography. Sociodemographical and clinical features of the patients were
recorded. The Montgomery Asberg Depression Rating Scale, the Beck Depression Inventory and the Epworth Sleepiness Scale were
administered. Psychiatric diagnoses were made by interviews based on the DSM-IV Axis I Disorders (SCID-I).
Results: According to the ICDSD-2, 19.6% (n=20) of the patients had a mild, 29.4% (n=30) had a moderate and 51,0% (n=52) had a severe
form of OSAS. The distribution of sex, marital status, and occupation are shown in Table I. The means of weight and height of the whole
sample were 91.15±16.78kg and 168.23±8.76cm, respectively. Fifty-seven point nine percent of the patients (n=59) had had a psychiatric
referral previously, 42.2% of them (n=43) did not. According to the body mass index (BMI), 5.9% of patients (n=6) were within normal
limits, 30.4% were (n=31) overweight, 54.9% were obese (n=59) and 8.8% were morbidly obese (n=9). The Epworth Sleepiness Scale total
score was significantly higher in severe OSAS patients (p=0.002). The relationship of mild and moderate OSAS with BMI was significant
(p=0.010). The median age of severe OSAS patients was significantly higher than mild OSAS patients (p=0.0529).
Thirty-one point four percent (n=32) of patients had 1 diagnosis according to the SCID-I, 22.5% (n=23) had more than one diagnosis, and
46.1% (n=47) did not have any diagnosis. The total scores of the BDI and the MADRS were 5.49±9.05 and 5.82±9.40, respectively.
Discussion: There are many risk factors for OSAS. Male predominance is present for adult OSAS patients. The number of male patients was
higher than female patients in this study. One of the most important risk factor is obesity (2). Most of the patients were obese or morbidly
obese in our group. The detected depression rate was correlated with many studies which reported higher depression rates in OSAS (2-5).
In this study the rate of anxiety disorders was higher than in the healthy population while being similar or lower than the rate estimated
in previous studies with OSAS patients.
Conclusion: Mental disorders associated with medical diseases are important clinical syndromes effecting morbidity and mortality.
Recognizing the symptoms and signs of OSAS is important. Regarding this issue, further studies with larger samples comparing different
subgroups are needed.
Key words: Obstructive sleep apnea, mental diseases
Bulletin of Clinical Psychopharmacology 2011;21(Suppl. 2):S200
S200 Bulletin of Clinical Psychopharmacology, Vol: 21, Supplement: 2, 2011 - www.psikofarmakoloji.org