SYMPOSIA

Bulletin of Clinical Psychopharmacology, Vol: 21, Supplement: 2, 2011 - www.psikofarmakoloji.org
Poster Presentations
[PP-103] Ref. No: 298
Adult primary enuresis nocturna: A case report
Yücel Yılmaz, Ömer Yanartaş, İshak Saygılı, Aytül Gürsü Hariri
Erenkoy Mental Health Training And Research Hospital, Istanbul, Turkey
E-mail: yilmazyucel@live.com
Introduction: Nocturnal enuresis (bed-wetting) is a hereditary, medical condition, which effects both children and adults (1). Beside this
there is few studies on pevalance of enuresis nocturna (EN) among adults. EN cases are seldomly reported. Although most of the patients
recover spontaneusly from EN, in the resistant cases illness persist through adulthood (2). The patients who have frequent bed-wetting in
their childhood have greater risk for persistence of symptoms (3).
Case: A 29-year-old single, male patient does not work. The patient has been suffering from bed-wetting at nights, 2-3 times per week
since his early childhood. He reports that he never had a long period free from bed-wetting at nights. He was suffering from bedwetting
only at nights and never had daytime wetting. The patient reported that bedwetting becomes more frequent when he was under stress or
felt unhappy about something and decreased in frequency when he felt less stressed out. While his military service, for a short period his
symptoms had stopped when his millitary service was over his symptom has started again. In last six months, after he has suffered from
thoughts of worthlessness, relationship issues with his father, and some economic problems his bed-wetting frequency increased. After
his first application to the Erenkoy Mental Health Training And Research Hospital outpatient clinic, a consultation with a neurologist and a
urologist was planned. He had been examined separately by a urologist, a neurologist and a psychiatrist. Several investigations had been
performed in which they could not detect any organic disease. These investigations included urine analysis, abdominal USG, cranial MRI,
and EEG. According to the results of these investigations, organic etiology was ruled out and 25 mg/day imipramine had been commenced.
Later we increased imipramine dosage to 50 mg/day and added behavioral homework to the treatment. In his familiy history, there were
similar symptoms in his brother wich had persisted until age 15th, and in his cousin which had persisted until he turned to 19 years old. The
treatment response of the patient was good; his compliance with pharmacological treatment and behavioral therapy techniques was good.
Discussion: Our case, according to DSM-IV-TR diagnostic criteria, was fulfilling the criteria for enuresis nocturna and major depressive
disorder on axis I. His problems about his functionality and his relationship with his father have caused an increase in his depressive
symptoms and his bed-wetting. We think that patient’s good response to treatment is related to his high motivation in his first psychiatric
application and his compliance with behavioral threapy. It is compatible with literature data that the relatives of the patient have similar
symptoms.
Key words: Enuresis nocturna, imipramine, behavioral therapy
References:
1. Yaluğ İ, Ünsalan N, Özten E, Öztep Kuruoğlu S, Tufan AE. Erişkinde ikincil enürezis nokturna: Bir olgu sunumu. Anadolu Psikiyatri Dergisi 2006; 7:185-190
2. Burgu B, Gokce MI, Gucuk A, Soygur T. Prospective evaluation of factors affecting the response and relapse rates to desmopressin therapy in male monosymptomatic
enuretic adults. Urology 2009; 74: 915–919
3. Yeung CK, Sihoe JD, Sit FK, Bower W, Sreedhar B, Lau J. Characteristics of primary nocturnal enuresis in adults: an epidemiological study. BJU Int 2004; 341-345
Bulletin of Clinical Psychopharmacology 2011;21(Suppl. 2):S185
[PP-104] Ref. No: 311
Major depressive disorder and the 5-HTTLPR in Spanish and Mexican populations
Pedro Dorado 1 , Hugo Trejo 2 , Elisa Alonso 2 , Eva Peñas Lledó 1 , Adrián Llerena 1 , Marisol López 3
1Clinical Research Centre (CICAB), Extremadura University Hospital and Medical School, Badajoz, Spain
2National Institute of Neurology and Neurosurgery Manuel Velasco Suárez. Mexico City, Mexico
3Metropolitan Autonomous University-Campus Xochimilco, Mexico City, Mexico
4Co-Principal Investigators
E-mail: allerena@unex.es
Preliminary evidence of an increased risk of suffering from MDD for individuals carrying the 5HTTLPR S allele was described in 70 Spanish
patients [1].
The present study aimed to analyze the potential relevance of the 5-HTTLPR genotypes and the risk of suffering from MDD in Mexicans
S185