SYMPOSIA

Bulletin of Clinical Psychopharmacology, Vol: 21, Supplement: 2, 2011 - www.psikofarmakoloji.org
Poster Presentations
The effectiveness of bupropion for treatment of kleptomania, which is classified as an impulse control disorder, is discussed on two cases
in this report.
Case 1: A 34 year-old married, women, graduated from high school presented with fatique, stress, lack of motivation, and complaints of
staying in house, which lasted for the last two months in March, 2011. She had been stealing objects which were not important for her
or she didn’t need for a year. She stated that she felt joy during kleptomanic behaviour and later felt guilty and depressed and she could
not leave the house.
She had substance abuse history and had been treated for major depression.
SCID-I revealed she had major depressive disorder recurring type and kleptomania.
For treatment, bupropion was given 150 mg/day initially, then increased to 300 mg/day. The depressive symptoms were apperently
reduced in 8th week of the treatment. In 12th week, psychiatric examination revealed that functionalty, stealing impulse, and behaviour
healed clearly.
Case 2: A 25 year-old single,women, graduated from high school presented with hypersomnia, eating too much, lying, suicide thoughts,
and stealing things that she didn’t need. Kleptomanic behaviour had begun one year ago.
She was told to be overweight when she was 8 year-old and tried to commit suicide when she was attending to secondary school. She
had been shopping compulsively for 3-4 years.
SCID-I revealed that she had major depressive disorder recurring type and kleptomania.
Bupropion 150 mg/day was started initially, then 300 mg/day was given for treatment. The depressive symptoms were reduced markedly
in the 10th week of the treatment. Desire and impulses to steal, hyperphagia, and suicide thoughts were found to be treated.
Discussion: There are studies (3-4) showed bupropion to be effective for treatment of pathological gambling and trichotillomania, both
of which are impulse control disorders. We investigated the effectiveness of bupropion treatment in two cases, who had kleptomania
and co-existing mood disorder. To our knowledge this is the first case report bupropion is used for kleptomania treatment. Larger and
controlled studies on kleptomania would make it possible to understand the pharmacotherapy and etiology of this disorder better.
References:
1. Hocaoğlu Ç, Kandemir G. The use of SSRI (Selective Serotonin Reuptake Inhibitors) in kleptomania’s treatment: case reports. Bulletin of Clinical Psychopharmacology
2004;14:204-8.
2. Bayle FJ, Caci H, Millet B, Richa S, Olie JP. Psychopathology and comorbidity of psychiatric disorders in patients with kleptomania. Am J Psychiatry 2003;160(8):1509-13.
3. Bhanji NH, Margolese HC. Alternative pharmacotherapy for trichotillomania: a report of successful bupropion use. J Clin Psychiatry 2004;65(9):1283.
4. Dannon PN, Lowengrub K, Musin E, Gonopolski Y, Kotler M. Sustained-release bupropion versus naltrexone in the treatment of pathological gambling: a
preliminary blind-rater study. J Clin Psychopharmacol 2005; 25(6):593-6.
Bulletin of Clinical Psychopharmacology 2011;21(Suppl. 2):S182-3
[PP-101] Ref. No: 251
A randomized, double-blind, placebo-controlled trial of celecoxib augmentation of
sertraline in the treatment of a drug-naïve women with major depression
Farshad Hashemian 1 , Marzieh Majd 1 , Seyed Mohammad Hosseini 2 , Ali Sharifi 1 , Maryam Vahdat Shariat Panahi 3 , Ofogh Bigdeli 1
1 Department of Clinical Pharmacy, Islamic Azad University, Pharmaceutical Sciences Branch, Tehran, Iran
2 Department of Psychiatry, Hamedan University of Medical Sciences, Hamedan, Iran
3 Islamic Azad University, Tehran Medical Branch, Iran
E-mail: majd.marzie@gmail.com
Objectives: A growing body of evidence strongly suggests that inflammatory process and immune responses are involved in the
pathophysiology of depression. While depression itself is considered a heterogeneous disorder, the involvement of immune system
further complicates the matter.
Meanwhile, several antidepressant medications (e.g. fluoxetine) have been reported to exert immunomodulatory properties, which may
affect human immune system and may partly contribute to their efficacy. Moreover, it must be noted that immune response/system
profoundly varies between the genders due to differences in sex hormones. However, there have been no controlled studies investigating
the benefits of celecoxib augmentation therapy in treatment-naïve women with depression.
To increase the homogeneity of the study population, the present study was designed to examine the antidepressant effects of celecoxib
augmentation of sertraline in the treatment of female drug-naïve patients with depression for 8 weeks.
Methods: Forty female patients diagnosed with first episode of major depression according to DSM-IV-TR criteria were recruited for this
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