SYMPOSIA

Poster Presentations
study, the Cronbach alpha coefficient of the questionnaire was calculated to be 0.88 for patients and 0.80 for experts, which was very
satisfactory. The data were analyzed by the SPSS software and Lisrel through the factor analysis method.
Results: Based on the responses of 401 patients and 406 experts, the current situation of access to medical care in the public hospitals
of Iran has lower than average quality and most of the patients and experts gave a low rating to each of the 5 factors of accessibility
in the current situation. In addition, the findings showed that the structure of access to medical care in Iranian public hospitals has a
5-dimensional structure containing individual characteristics, service providing system, social-geographic features, health policy making
and management strategies. The relationship among the 5 dimensions was meaningful from 0.13 for the correlation of health policy
making with the individual characteristics to 0.40 for the correlation of health policy making with the management strategies.
Conclusions: The findings show that the service providing system had the highest quality and was the most effective factor on having
access to medical care structure. It seems that it can be helpful to pay attention to the above factors especially in programming and policy
making to improve access to medical care by distributing the standardized number of beds and specialists based on the population of
each region, training, organizing, and managing the human resources, and improving the service providing system process.
Key words: Feature, access, access to health care, medical care
Bulletin of Clinical Psychopharmacology 2011;21(Suppl. 2):S155-6
[PP-058] Ref. No: 174
Smoking behaviour during the course of paroxetine treatment: A case report
Neslihan Akkişi Kumsar, Atila Erol
Sakarya Training and Research Hospital, Sakarya, Turkey
E-mail: drneslihanakkisi@yahoo.com
Selective serotonin reuptake inhibitors are used for the treatment of a wide range of psychiatric disorders, although nicotine craving
attributed to the use of serotonin reuptake inhibitors especially paroxetine has not yet been reported in the literature. Here we present
a case, who developed nicotine craving and started to smoke cigarettes after initiation of 20mg/day paroxetine, and discuss possible
mechanisms of this side effect while reviewing current status of the literature. A 25 year-old female patient was evaluated at our outpatient
clinic and diagnosed with generalized anxiety disorder. She was given paroxetine 20mg/day for four weeks. While her symptomatology
improved by the second week of the treatment, she complained of nicotine craving at the fourth week. During psychiatric assessment
there was not any history of smoking, alcohol or any other substance use disorder. She mentioned that she started smoking one package/
day after starting the paroxetine treatment. The craving for nicotine decreased after the drug was discontinued and she quit smoking
within two weeks. We did not find any report of smoking behaviour attributed to SSRIs in the literature, although there is a study about
decreased smoking behaviour during paroxetine treatment. To the best of our knowledge this case is the first one in the literature. More
research is needed to exlore nicotine craving and SSRIs.
Key words: Craving, cigarette, paroxetine
Bulletin of Clinical Psychopharmacology 2011;21(Suppl. 2):S156
[PP-059] Ref. No: 190
Development of a SNP genotyping panel and a medical decision support algorithm
to predict drug response in schizophrenia
Hüseyin Alper Döm 1 , Mehmet Ali Döke 2 , Yemliha Yener Tuncel 1 , Gürkan Üstünkar 3 , Yeşim Aydın Son 4
1 Middle East Technical University, Bioinformatics Graduate Program Ankara, Turkey
2 Middle East Technical University, Department of Biological Sciences, Ankara, Turkey
3 Middle East Technical University, Informatics Institute, Department of Information Science, Ankara, Turkey
4 Middle East Technical University, Informatics Institute, Department of Health Informatics, Ankara, Turkey
E-mail: h.alper.dom@gmail.com
Genome Wide Association Studies (GWAS) of Single Nucleotide Polymorphisms (SNPs) is leading the development of personalized
medicine approaches to predict and diagnose diseases or to determine drug response in individual patients. As the basic research
provides all the genomic information and interpretation of these data, translational research has to be conducted in order to develop
S156 Bulletin of Clinical Psychopharmacology, Vol: 21, Supplement: 2, 2011 - www.psikofarmakoloji.org