SYMPOSIA

Poster Presentations
[PP-046] Ref. No: 240
Influence of polymorphism of the norepinephrine transporter gene (SLC6A2) and
alpha-2 adrenergic receptor gene (ADRA2A) on regional cerebral blood flow
in a Korean ADHD sample: a preliminary study
Younghui Yang 1 , Jaewon Kim 2 , Boongnyun Kim 2 , Minsup Shin 2 , Soochurl Cho 2
1 Department of Psychiatry, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea
2 Division of Child and Adolescent Psychiatry, Seoul National University Hospital, Seoul, Republic of Korea
E-mail: nauyoung@gmail.com
Some genes related to the noradrenergic system have been investigated as candidate genes in Attention Deficit Hyperactivity Disorder
(ADHD). Through functional brain imaging studies, it has been reported that brain areas such as the prefrontal cortex (PFC), dorsal
anterior cingulate cortex, and striatum show abnormal findings in ADHD patients. We have investigated whether there was an association
between polymorphism of the noradrenergic system related genes (SLC6A2 and ADRA2A) and regional cerebral blood flow (rCBF) in a
Korean ADHD sample.
Methods: A total of thirty-six children (31 boys and 5 girls, mean age: 8.9 (± 1.84) years) participated in this study. Subjects were recruited
from the outpatient’s clinic of child and adolescent psychiatry in the Seoul National University Hospital. The diagnosis of ADHD was made
based on the DSM-IV-TR. All patients were drug naïve at the time of image acquisition. Genotyping of SLC6A2 (G1287A, -3081(A/T)) and
ADRA2A (Dral, Mspl) was done. SPM8 (Statistical parametric mapping 8) was used to compare images between the two groups divided
by each genotype.
Results: Children with the G/A and A/A genotypes at the SLC6A2 G1287A polymorphism showed decreased rCBF in the right inferior
temporal gyrus and the left middle temporal gyrus compared to children with G/G genotype (uncorrected p-value< 0.001). In ADRA2A
Mspl polymorphism, children with the C/G and C/C genotypes showed increased rCBF in the left striatum and the left cingulate gyrus and
decreased rCBF in the left cerebellar vermis compared to children with G/G genotype.
There were no significant rCBF alterations across genotypes in the SLC6A2 -3081(A/T) and ADRA2A Mspl genes.
Conclusion: This study showed that the noradrenergic system related genes might be associated with functional brain abnormalities in
children with ADHD.
Key words: ADHD, neuroimaging, SLC6A2, ADRA2A
Bulletin of Clinical Psychopharmacology 2011;21(Suppl. 2):S148
[PP-047] Ref. No: 129
Do we need specialist clinics to monitor metabolic side effects on chronic
bipolar patients in Treatment? – Audit of management of bipolar disorder against
NICE guidelines in South Staffordshire NHS Trust, UK
Fiesal Jan, Vanathi Kennedy
Foundation House, St. Georges’ Hospital, Corporation Street, ST16 3AG, Stafford
E-mail: khalidnoma@hotmail.com
Objective: To highlight the pharmacological management of patients with Bipolar Affective Disorder and to evaluate whether the
management meets the current standards as set up by recognised guidelines, especially those underlined by NICE guidelines.
Method: The audit data were collected from a patient population from the West patch of South Staffordshire and focussed on inpatients
from the 2 adult units based at Stafford and a psychiatric ICU. It also included a minimum of 5 patients of both genders from all the
community teams. The selection was random and not based on severity or duration of the disorder, co-morbidity or other accompanying
diagnoses, for e.g, Personality disorder.
The audit tool was devised by the clinical audit coordinator in conjunction with clinicians.
Results: Twenty of twenty-eight 28 patients (72%) were on mood stabilizers, either lithium or sodium valproate, with sodium valproate
the more preferred drug.
Twelve of twenty-eight (43%) were on antipsychotics. Three of seven (43%) patients, who did not respond to combination treatment,
were started on lamotrigine.
In 21/22 (95%) of the patients, antidepressants were stopped.
S148 Bulletin of Clinical Psychopharmacology, Vol: 21, Supplement: 2, 2011 - www.psikofarmakoloji.org