SYMPOSIA

Poster Presentations
[PP-033] Ref. No: 192
Gender specific metabolic adverse effects in bipolar patients: A comparison
between lithium, quetiapine and olanzapine
Sermin Kesebir, Burak Baykaran, Burak Toprak, Ahmet Ertan Tezcan
Erenkoy TEHMND, Istanbul, Turkey
E-mail: serminkesebir@hotmail.com
Objective: There is some evidence showing gender based differences in the side effects of atypical antipsychotic drugs. The aim of this
study was to determine the differences between lithium, quetiapine and olanzapine with regard to their effects on metabolic variables in
bipolar disorder and to assess the findings in terms of gender differences.
Method: Twenty-eight female and 29 male cases diagnosed with bipolar disorder type I according to the DSM-IV, taking lithium or
quetiapine or quetiapine+lithium or olanzapine or olanzapine+lithium, were evaluated consecutively. For evaluation, being in a remission
period was set as a criterion for these cases. Patient interviews were carried out with SCID-I and SKIP-TURK. Blood samples were taken from
the patients in order to determine PRL, blood lipids and HbA1c levels.
Results: Mean age, mean age of onset, number of manic, depressive, and total episodes, functionality, and PRL levels were similar between
female and male patients. BMI, HbA1c, cholesterol, triglycerides, LDL and HDL levels are found to be similar between the two groups. Both
in female and male patients, no difference was found between the lithium, quetiapine and quetiapine+lithium and the olanzapine and
olanzapine+lithium groups in terms of BMI, HbA1c, cholesterol, triglyceride, LDL and HDL levels. The only difference (although not significant)
among the three groups was the level of cholesterol in women treated with lithium, which was found to be lower than in the other two groups.
Conclusions: This insignificant difference was found while the clinical properties and PRL levels were similar among the lithium,
quetiapine and quetiapine+lithium and the olanzapine and olanzapine+lithium groups. Future studies with a specific focus on this topic
are needed in order to have a better understanding of the basic mechanisms of gender differences.
Key words: Gender, metabolic side effect, psychotropics, bipolar disorder
Bulletin of Clinical Psychopharmacology 2011;21(Suppl. 2):S140
[PP-034] Ref. No: 161
New model of psychogenic stress-induced depression and antioxidant system of rat brain
Konstantin Chichinadze 1 , Tamar Domianidze 1 , Tamar Matitaishvili 1 , Ia Labadze 1 , Ann Lazarashvili 2 , Mikhail Khananashvili 1
1Laboratory of Behavior and Cognitive Functions, Life Sciences Research Center, Tbilisi, Georgia
2Department of Pathology, Tbilisi State University, Tbilisi, Georgia
E-mail: k.chichinadze@lifescience.org.ge
The present article describes results of investigation of lipid peroxidation and antioxidant enzyme activity in the brain cells of laboratory
rats, that were subjected to a depression-like state. The above-mentioned state was achieved by means of a new model of depression
elaborated by us. The model is based on the application of stressors of psychogenic nature.
Our investigations demonstrated that in the depression-like state activity of lipid peroxidation processes increase, which was confirmed
by increase of concentration of its end product – malondialdehyde, both in mitochondrial and cytosolic fractions of brain cells. In
response to oxidative stress in mitochondria, activity of antioxidant system –namely the leading intracellular antioxidant superoxide
dismutase (SOD) – increased. On the other hand, concentration of another important antioxidant –catalase– decreased. Most probably,
the depletion of antioxidative potential of the cell, related to depression, proceeds at various speeds in various enzymatic systems.
Administration of the antidepressant drug –fluoxetine– led to the normalization of intensity of lipid peroxidation and overall activity of
antioxidative systems. Thus, if activity of these processes increases, antidepressants cause their down-regulation and in they decrease
–antidepressants lead to their up-regulation. As a final result, this leads to normalization of cell functioning.
Key words: Animal model of depression, lipid peroxidation, antidepressants
Bulletin of Clinical Psychopharmacology 2011;21(Suppl. 2):S140
S140 Bulletin of Clinical Psychopharmacology, Vol: 21, Supplement: 2, 2011 - www.psikofarmakoloji.org