SYMPOSIA

Poster Presentations
Conclusion: This is the first most extensive population where losartan has been used as a probe drug to evaluate the CYP2C9 activity in
vivo. The urinary losartan to E3174 metabolic ratio after a 50mg losartan dose was found to be a safe and useful phenotyping assay for
CYP2C9 activity in vivo. The CYP2C9*3 variant allele is a major determinant of the enzyme activity, and it decreases losartan metabolism
significantly, while the CYP2C9*2 allele has less impact on enzyme function.
Key words: Cytochrome P450 2C9, genetic polymorphism, losartan, ecuadorian population
Bulletin of Clinical Psychopharmacology 2011;21(Suppl. 2):S131-2
[PP-019] Ref. No: 194
Efficacy of progressive muscle relaxation training on anxiety, depression and
quality of life in cancer patients under chemotherapy
Sepideh Ershadmanesh Herizchi 1 , Isa Tt Piri 2 , Iraj Tt Asvadi 3 , Zohreh Tt Sanaat 4 , Mrs Tt Golchin 5 , Reza Tt Shabanloui 5
1 Assistant Professor of Psychiatry, 2 Psychologist, 3 Professor of Oncology,
4 Z.Sanaat, Assistant Professor of Oncology, 5 MS of Nursing, Hematology & Oncology Research Center-2010, Tabriz, Iran
E-mail: sherizchi@gmail.com
Introduction: Chemotherapy is one of the common treatment methods for cancer. However, many side effects can be seen among
patients and some of them are very serious and painful. Alopecia, anorexia, vomiting, pain in the limbs, headache, and backache are some
unwanted effects. On the other hand many patients suffer from psychiatric disorders especially anxiety and depression probably due to
the drugs or coping with the disease state. These disorders can cause some problems in the treatment process and the Quality of life.
Patients with anxiety and depression can be treated with drugs or psychotherapy.
Progressive Muscle Relaxation [PMR] training is a cost effective self-help method promoting mental health in healthy participants.
The aim of this study was to determine anxiety, depression, and quality of life dimensions of cancer patients undergoing chemotherapy
and the effect of progressive muscle relaxation training in improving their mental health and quality of life.
Materials and Methods: This research was designed as a randomized clinical trial. Sixty cancer inpatients undergoing chemotherapy
in the Tabriz Hematology & Oncology ward in 2009 were randomly selected and divided into two groups, intervention or control. All
participants provided a written formal consent.
Anxiety, depression, and quality of life dimensions were determined with HADS and EORTC QLQ-C30 questionnaires. SPSS 16 software
was employed for the data analysis.
After completion of the 1st questionnaires by all participants, the case group was trained in progressive muscle relaxation in 3-6 person
groups, with the aim of doing it by themselves in the hospital and after discharge 2-3 times a day. At 2 weeks and one and three months
after the intervention, questionnaires were completed again by both groups, and the results were compared.
Results: After initial data analysis almost all of the participants were satisfied with the learning and the experience of this technique.
There was no significant difference between the scores of the case and control groups after PMR after 2 weeks and 1 month (p >0.05).
However, after 3 months, anxiety, depression and quality of life dimensions were significantly improved (p