SYMPOSIA
SYMPOSIA
SYMPOSIA
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Poster Presentations<br />
Conclusion: This is the first most extensive population where losartan has been used as a probe drug to evaluate the CYP2C9 activity in<br />
vivo. The urinary losartan to E3174 metabolic ratio after a 50mg losartan dose was found to be a safe and useful phenotyping assay for<br />
CYP2C9 activity in vivo. The CYP2C9*3 variant allele is a major determinant of the enzyme activity, and it decreases losartan metabolism<br />
significantly, while the CYP2C9*2 allele has less impact on enzyme function.<br />
Key words: Cytochrome P450 2C9, genetic polymorphism, losartan, ecuadorian population<br />
Bulletin of Clinical Psychopharmacology 2011;21(Suppl. 2):S131-2<br />
[PP-019] Ref. No: 194<br />
Efficacy of progressive muscle relaxation training on anxiety, depression and<br />
quality of life in cancer patients under chemotherapy<br />
Sepideh Ershadmanesh Herizchi 1 , Isa Tt Piri 2 , Iraj Tt Asvadi 3 , Zohreh Tt Sanaat 4 , Mrs Tt Golchin 5 , Reza Tt Shabanloui 5<br />
1 Assistant Professor of Psychiatry, 2 Psychologist, 3 Professor of Oncology,<br />
4 Z.Sanaat, Assistant Professor of Oncology, 5 MS of Nursing, Hematology & Oncology Research Center-2010, Tabriz, Iran<br />
E-mail: sherizchi@gmail.com<br />
Introduction: Chemotherapy is one of the common treatment methods for cancer. However, many side effects can be seen among<br />
patients and some of them are very serious and painful. Alopecia, anorexia, vomiting, pain in the limbs, headache, and backache are some<br />
unwanted effects. On the other hand many patients suffer from psychiatric disorders especially anxiety and depression probably due to<br />
the drugs or coping with the disease state. These disorders can cause some problems in the treatment process and the Quality of life.<br />
Patients with anxiety and depression can be treated with drugs or psychotherapy.<br />
Progressive Muscle Relaxation [PMR] training is a cost effective self-help method promoting mental health in healthy participants.<br />
The aim of this study was to determine anxiety, depression, and quality of life dimensions of cancer patients undergoing chemotherapy<br />
and the effect of progressive muscle relaxation training in improving their mental health and quality of life.<br />
Materials and Methods: This research was designed as a randomized clinical trial. Sixty cancer inpatients undergoing chemotherapy<br />
in the Tabriz Hematology & Oncology ward in 2009 were randomly selected and divided into two groups, intervention or control. All<br />
participants provided a written formal consent.<br />
Anxiety, depression, and quality of life dimensions were determined with HADS and EORTC QLQ-C30 questionnaires. SPSS 16 software<br />
was employed for the data analysis.<br />
After completion of the 1st questionnaires by all participants, the case group was trained in progressive muscle relaxation in 3-6 person<br />
groups, with the aim of doing it by themselves in the hospital and after discharge 2-3 times a day. At 2 weeks and one and three months<br />
after the intervention, questionnaires were completed again by both groups, and the results were compared.<br />
Results: After initial data analysis almost all of the participants were satisfied with the learning and the experience of this technique.<br />
There was no significant difference between the scores of the case and control groups after PMR after 2 weeks and 1 month (p >0.05).<br />
However, after 3 months, anxiety, depression and quality of life dimensions were significantly improved (p