SYMPOSIA

Poster Presentations
[PP-005] Ref. No: 208
Cabergoline induced manic episode: A case report
Rabia Nazik Yuksel, Zeynep Elyas Kaya, Nesrin Dilbaz
Department of Psychiatry, Ankara Numune Training and Research Hospital, Ankara, Turkey
E-mail: rabia.nky@gmail.com
Cabergoline is an orally administered synthetic dopamine agonist, which is used for the treatment of hyperprolactinemia, Parkinson
Disease, and antipsychotic-induced prolactin elevation.
One major characteristic of cabergoline is its long duration of effect. It is highly effective in suppressing prolactin levels up to 21 days after
a single 1 mg oral dose. The prolonged elimination half-life offers an advantage of once daily dosing but it might be a handicap in terms
of wash-out of adverse effects like psychosis.
Cabergoline has been associated with adverse reactions consistent with other dopaminergic agonists including cardiovascular,
gastrointestinal, and neuropsychiatric effects. It is known that dopaminergic treatment is a remarkable risk factor for psychosis. A number
of reports implicate dopamine agonists in the development of psychosis. But there is no report in the literature on dopamine agonistinduced
mania. In this case, we report the first manic episode occurring after cabergoline use for hyperprolactinemia treatment. In
susceptible individuals, cabergoline can cause manic episodes and cabergoline should be used more carefully considering the risk-benefit
ratio.
Key words: Cabergoline, manic episode, bipolar disorder, dopamine agonists, hyperprolactinemia
Bulletin of Clinical Psychopharmacology 2011;21(Suppl. 2):S124
[PP-006] Ref. No: 218
Substance use and eating patterns of female adolescent students
Joung Sook Ahn, Jongho Shin, Ki Chang Park, Seongho Min, Min Hyuk Kim
Department of Psychiatry, Wonju Medical Center, Yonsei University, Wonju, South Korea
E-mail: jsahn@yonsei.ac.kr
Introduction: The problems of smoking and/or drinking among female adolescents come to the front as a serious social problem, as
the rate of occurrence of these behaviors among female adolescents is on the increase. Substance use disorders and eating disorders
frequently co-occur in the presence of other psychiatric disorders. Although this co-occurrence suggests the possibility of shared factors
in the etiology of these two problems, research to date has not established such links. Regardless of the meaning of the association, the
reality that substance use disorders and eating disorders frequently co-occur has important implications for assessment, treatment, and
future research, especially for female adolescents.
Objectives: The first objective of this research was to estimate the rates of smoking and drinking problems among female adolescent
students and the second was to examine their association with psychopathologies and eating behaviors.
Methods: We surveyed 861 female adolescents, 405 students in the 8th grade of one middle school and 456 students in the 10th grade
from two high schools in Wonju, South Korea. Each student completed a questionnaire that consisted of demographic data, parental
monitoring, her attitude toward her parents (CATP), her own attitude toward alcohol, tobacco, and foods, BMI, and the difference between
perceived and ideal body images (DoBI). The TFEQ (Three Factor Eating Questionnaire) for eating patterns and the self-report version of
SDQ (Strengths and Difficulties Questionnaire-self report) for psychopathology were also administered.
Results: 1) For the 8th graders, the prevalence of smoking and drinking were 8.6% and 18.4%, respectively. These prevalences were
14% and 48.3% correspondingly in the 10th graders (Table 1). 2) Female adolescents with smoking and/or drinking habits, except for
the 10th graders with smoking, showed inattention-hyperactivity and conduct problems more frequently than the students without
substance use habits. 3) The 10th graders who reported drinking had eating patterns characterized by dietary restraints, and the 8th
graders with drinking problems showed disinhibition of eating patterns (Table 2). 4) The female adolescents with a high score in the
difference between perceived and ideal body image showed inattention-hyperactivity and emotional problems more frequently
(Table 3).
Conclusions: From these results, we suggest that middle-school girls may start smoking to reduce their weight. The lower the disinhibition
score is, the higher the risk of smoking and drinking. For the high-school girls, the lower the dietary restraint score is, the higher the risk
of drinking. In conclusion, smoking and drinking behaviors are closely related to externalizing problems such as inattention-hyperactivity
S124 Bulletin of Clinical Psychopharmacology, Vol: 21, Supplement: 2, 2011 - www.psikofarmakoloji.org