SYMPOSIA

Bulletin of Clinical Psychopharmacology, Vol: 21, Supplement: 2, 2011 - www.psikofarmakoloji.org
Abstracts of Oral Presentations
mg/kg) and xylazine (4 mg/kg) intraperitoneally (IP)), an ECG was taken in derivation (D) I and the normal QTc interval was determined. To
calculate the QTc interval, Bazett’s formula was used.
The rats were divided into 3 groups (n=6). For the first group, 3 mg/kg ziprasidone and saline, for the second group, 3 mg/kg ziprasidone
and 1 mg/kg metoprolol and for the third group, 3 mg/kg ziprasidone and 2 mg/kg diltiazem were administered intraperitoneally.
Two hours later, under anesthesia, the QTc interval was calculated by taking the ECG in derivation I.
Results: In the first group of rats, given ziprasidone and saline the QTc interval (0.161±0.01 s) was significantly (p