Experimental infection and protection against ... - TI Pharma

Humoral immune responses to a single allele PfAMA1 vaccine in healthy malarianaïve
adults.
Fraction of IgG remaining (%)
100
80
60
40
20
0
100
80
60
40
20
0
100
80
60
40
20
0
0
0.14
0.41
Alhydrogel 10 Alhydrogel 50
ISA 720 10 ISA 720 50
AS02 10 AS02 50
1.23
3.7
11.11
33.33
100
0
Competitor concentration (µg/mL)
Figure 3. Competition ELISA using four different competitor antigens on FVO coated
plates in serum obtained on day 84.
Concentration of competitor antigen is depicted on the x-axis (µg /ml) and the fraction
remaining bound to the ELISA plate is depicted on the y-axis (%). Light Blue = FVO AMA1
(homologous), Orange = HB3 AMA1, Green = CAMP AMA1 and Dark Blue = 3D7 AMA1.
Treatment groups are indicated by Adjuvant name and AMA1 dose, respectively.
0.14
0.41
1.23
3.7
11.11
33.33
100
65