Experimental infection and protection against ... - TI Pharma

Contents
Contents 5
Chapter 1 - Introduction 7
Section 1 - Apical Membrane Antigen 1 29
Chapter 2 - Safety and Immunogenicity of a Recombinant Plasmodium
falciparum AMA1 Malaria vaccine Adjuvanted with Alhydrogel TM, Montanide
ISA 720 or AS02. 31
Chapter 3 - Humoral immune responses to a single allele PfAMA1 vaccine in
healthy malaria-naïve adults. 57
Chapter 4 - A saturation of antibody avidity and concentration induced by
malaria vaccine candidate Apical Membrane Antigen 1 81
Section 2 - Controlled human malaria infection model 95
Chapter 5 - Comparison of clinical and parasitological data from experimental
human malaria challenge trials 97
Chapter 6 - Efficacy of pre-erythrocytic and blood-stage malaria vaccines can be
assessed in small sporozoite challenge trials in human volunteers 117
Chapter 7 - NF135.C10: a new Plasmodium falciparum clone for controlled
human malaria infections 129
Chapter 8 - Induction of malaria in volunteers by intradermal injection of
cryopreserved Plasmodium falciparum sporozoites 151
Section 3 - Whole parasite inoculation 171
Chapter 9 - Protection against a Malaria Challenge by Sporozoite Inoculation 173
Chapter 10 - Long-term protection against malaria after experimental sporozoite
inoculation 193
Chapter 11 - General Discussion 215
Chapter 12 - Summary, Samenvatting, List of publications, Dankwoord, C.V. 243