Experimental infection and protection against ... - TI Pharma

Introduction 21
- to identify parameters influencing the power of CHMI to detect vaccine
efficacy of pre-erythrocytic and erythrocytic malaria vaccines (Chapter
6)
We next will address two important aspects of improvement to the CHMI model:
- to increase the portfolio of Pf strains that can be used for infection
(Chapter 7)
- to investigate the administration of parasites by needle (Chapter 8)
Can protection to malaria in humans be efficiently induced by inoculation of
live whole sporozoites?
The inoculation of irradiated sporozoites by mosquito bite has shown to induce
full protection in humans, albeit inefficiently and with limited longevity. We will
explore whether viable intact sporozoites induce protection more efficiently,
eventually aiming to create a model for malaria immunity. The administration of
chloroquine prophylaxis will prevent clinical disease whilst the exposure to
viable sporozoites allows exposure of parasite antigen. We address the following
specific objectives:
- to induce protection to Pf malaria in malaria naïve volunteers by
exposure to parasites whilst taking chloroquine prophylaxis (Chapter 9)
- to investigate the longevity of induced protection (Chapter 10)