Experimental infection and protection against ... - TI Pharma

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Protection against a Malaria Challenge by Sporozoite Inoculation 179 Abdominal pain mild 2 moderate severe Vera [n=10) Controls [n=5) Post immunization Post Post immunization challenge Post challenge I II III I II III Fatigue mild 1 1 7 1 2 moderate 2 1 1 2 severe 1 Fever mild 2 moderate 1 severe 2 5 Headache mild 4 7 2 3 2 moderate 2 1 1 1 1 3 severe 1 1 Loss of appetite mild 1 moderate severe Malaise mild 1 1 1 moderate 2 1 severe 1 1 5 Myalgia mild 1 2 3 moderate 2 1 4 severe 1 Nausea mild 3 1 1 1 1 moderate 1 1 1 1 severe 1 Vomiting mild 1 moderate 1 severe Overall† mild 4 [40%) moderate 3 [30%) severe 2 [20%) 1 [10%) 1 [10%) 8 [80%) 1 [10%) 1 3 [20%) [60%) 1 2 1 [20%) [40%) [20%) 1 [20%) 5 [100%) Table 1. Adverse events after the first, second, and third exposures to immunizing mosquito bites and after challenge with infectious mosquito bites. * Subjects could have more than one adverse event and reports of events could have been either solicited or unsolicited. Only adverse events possibly or probably related to the study are listed.† The highest-grade event is listed per subject per infection.† Highest grade event listed per volunteer per infection.
180 Chapter 9 Figure 2. Parasitemia in the Vaccine Group and the Control Group. Panel A shows the mean number of Plasmodium falciparum parasites per millilitre, as measured by nucleic acid sequence–based amplification (NASBA), after each of three immunizations on days before infection and during expected blood-stage parasitemia (days 6 to 10) in the vaccine group. The numbers of subjects who had positive results on peripheral blood smears for malarial parasites (MPS) and NASBA are shown below the graph. Panel B shows the mean number of P. falciparum parasites in 5 subjects in the control group and 10 subjects in the vaccine group, as determined by real-time polymerase-chain-reaction assay before treatment with artemether–lumefantrine. The I bars denote standard errors.
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Experimental infection and protecti
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Experimental infection and protecti
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Contents Contents 5 Chapter 1 - Int
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Introduction 9 Malaria Malaria is o
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Introduction 11 Preclinical Clinica
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Introduction 13 pipeline of clinica
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Introduction 15 The division of ant
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Introduction 17 Figure 4. Populatio
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Introduction 19 candidates. Initial
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Introduction 21 - to identify param
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Introduction 23 20. Nussenzweig RS,
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Introduction 25 50. Ouedraogo AL, R
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Introduction 27 RTS,S/AS02 in malar
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Chapter 2 Safety and Immunogenicity
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Safety and Immunogenicity of a Reco
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Chapter 3 Humoral immune responses
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Humoral immune responses to a singl
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Chapter 4 82 Abstract The functiona
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84 Chapter 4 Figure 1. Schematic re
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86 Chapter 4 Concentration (mg/ml,
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88 Chapter 4 Figure 4: Correlation
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90 Chapter 4 positively correlated
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92 Chapter 4 Acknowledgements The a
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94 Chapter 4 determinant of subsequ
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Chapter 5 Comparison of clinical an
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Comparison of clinical and parasito
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Chapter 6 Efficacy of pre-erythrocy
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Efficacy of pre-erythrocytic and bl
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Page 154 and 155: Induction of malaria in volunteers
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Page 177 and 178: 176 Chapter 9 Figure 1. Study desig
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Page 193 and 194: 192 Chapter 9 medium A (Caltag Labo
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Page 197 and 198: 196 Chapter 10 Pre-erythrocytic sta
Page 199 and 200: 198 Chapter 10 procedures described
Page 201 and 202: 200 Chapter 10 by hand-dissection.
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Page 207 and 208: 206 Chapter 10 temperature (Pearson
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Page 211 and 212: 210 Chapter 10 cytokine measurement
Page 213 and 214: 212 Chapter 10 14. Hermsen CC, Telg
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Page 218 and 219: General Discussion 217 occurrence o
Page 220 and 221: General Discussion 219 mediating th
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Page 226 and 227: General Discussion 225 and between
Page 228 and 229: General Discussion 227 immunologica
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General Discussion 229 to induce pr
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General Discussion 231 Conclusions
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General Discussion 233 References 1
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General Discussion 235 polymorphonu
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General Discussion 237 57. Church L
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General Discussion 239 85. Beier JC
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General Discussion 241 118. Mueller
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Chapter 12 Summary Samenvatting Lis
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246 Chapter 12 Controlled human mal
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Summary, Samenvatting, List of publ
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254 Chapter 12 Roestenberg M, Teirl
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