Experimental infection and protection against ... - TI Pharma

Induction of malaria in volunteers by intradermal injection of cryopreserved
Plasmodium falciparum sporozoites
Matheny, Yingda Wen, Keith Nelson, James Overby, Virak Pich, Thomas Mitchell;
Dissection: Richard Fan; Purification: Lixin Gao, Ray Xu; Formulation and
Cryopreservation: Adam Ruben, Aderonke Awe, Quality Assurance and Quality
Control: Irina Belyakova, Mary King; Assays: Chinnamma Chakiath; Rana
Chattopadhyay, Charles Anderson, Solomon Conteh, Gwynne Roth; Regulatory
and Clinical Affairs: Tooba Murshedkar. We are grateful for Sanaria’s Operations
and Legal teams, especially Robert Thompson, Alexander Hoffman, and David
Dolberg. We thank the entire Protein Potential Team including, Adriana
Ahumada, Maria Socorro Orozco, Bing Jiang, Emily Chen. We also thank MSource
(Belgium, now CromSource, Italy) for clinical monitoring.
Funding
Manufacturing of PfSPZ Challenge and this clinical trial were funded by
TIPharma, grant number T4-102. ACT is funded by the European Malaria Vaccine
Development Association, KNM was funded by a Mozaiek grant from the
Netherlands Organisation for Scientific Research. The development and
manufacturing of PfSPZ Challenge was also supported by Small Business
Innovation Research (SBIR) grants R44AI058375-03,04,05,05S1 from NIAID/NIH
and through Agreement 07984 from the PATH Malaria Vaccine Initiative.
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