Experimental infection and protection against ... - TI Pharma
Experimental infection and protection against ... - TI Pharma Experimental infection and protection against ... - TI Pharma
Comparison of clinical and parasitological data from experimental human malaria challenge trials 15. Webster DP, Dunachie S, Vuola JM et al. Enhanced T cell-mediated protection against malaria in human challenges by using the recombinant poxviruses FP9 and modified vaccinia virus Ankara. Proc Natl Acad Sci U S A 2005; 102:4836- 4841. 16. Walther M, Dunachie S, Keating S et al. Safety, immunogenicity and efficacy of a pre-erythrocytic malaria candidate vaccine, ICC-1132 formulated in Seppic ISA 720. Vaccine 2005; 23:857-864. 17. McConkey SJ, Reece WH, Moorthy VS et al. Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans. Nat Med 2003; 9:729-735. 18. Porter DW, Thompson FM, Berthoud TK et al. A human Phase I/IIa malaria challenge trial of a polyprotein malaria vaccine. Vaccine 2011; 29:7514-7522. 19. Bousema JT, Roeffen W, van der KM et al. Rapid onset of transmission-reducing antibodies in javanese migrants exposed to malaria in Papua,Iindonesia. Am J Trop Med Hyg 2006; 74:425-431. 20. Ponnudurai T, Lensen AH, van Gemert GJ, Bensink MP, Bolmer M, Meuwissen JH. Infectivity of cultured Plasmodium falciparum gametocytes to mosquitoes. Parasitology 1989; 98 Pt 2:165-173. 21. Nieman AE, de MQ, Roestenberg M et al. Cardiac complication after experimental human malaria infection: a case report. Malar J 2009; 8:277. 22. Visser HK. Experimental malaria in human volunteers: ethical aspects. Neth J Med 2005; 63:41-42. 23. de Mast Q, Groot E, Lenting PJ et al. Thrombocytopenia and release of activated von Willebrand Factor during early Plasmodium falciparum malaria. J Infect Dis 2007; 196:622-628. 24. de Mast Q, de Groot PG, van Heerde WL et al. Thrombocytopenia in early malaria is associated with GP1b shedding in absence of systemic platelet activation and consumptive coagulopathy. Br J Haematol 2010; 151:495-503. 25. Ali H, Ahsan T, Mahmood T, Bakht SF, Farooq MU, Ahmed N. Parasite density and the spectrum of clinical illness in falciparum malaria. J Coll Physicians Surg Pak 2008; 18:362-368. 26. Beier JC, Davis JR, Vaughan JA, Noden BH, Beier MS. Quantitation of Plasmodium falciparum sporozoites transmitted in vitro by experimentally infected Anopheles gambiae and Anopheles stephensi. Am J Trop Med Hyg 1991; 44:564-570. 27. Jin Y, Kebaier C, Vanderberg J. Direct microscopic quantification of dynamics of Plasmodium berghei sporozoite transmission from mosquitoes to mice. Infect Immun 2007; 75:5532-5539. 28. Frischknecht F, Baldacci P, Martin B et al. Imaging movement of malaria parasites during transmission by Anopheles mosquitoes. Cell Microbiol 2004; 6:687-694. 29. Pumpuni CB, Mendis C, Beier JC. Plasmodium yoelii sporozoite infectivity varies as a function of sporozoite loads in Anopheles stephensi mosquitoes. J Parasitol 1997; 83:652-655. 115
116 Chapter 5 30. Ponnudurai T, Lensen AH, van Gemert GJ, Bolmer MG, Meuwissen JH. Feeding behaviour and sporozoite ejection by infected Anopheles stephensi. Trans R Soc Trop Med Hyg 1991; 85:175-180. 31. Rickman LS, Jones TR, Long GW et al. Plasmodium falciparum-infected Anopheles stephensi inconsistently transmit malaria to humans. Am J Trop Med Hyg 1990; 43:441-445. 32. Jeffery GM, Young MD, Burgess RW, Eyles DE. Early activity in sporozoiteinduced Plasmodium falciparum infections. Ann Trop Med Parasitol 1959; 53:51-58. 33. Rosenberg R, Wirtz RA, Schneider I, Burge R. An estimation of the number of malaria sporozoites ejected by a feeding mosquito. Trans R Soc Trop Med Hyg 1990; 84:209-212. 34. Hoffman SL, Billingsley PF, James E et al. Development of a metabolically active, non-replicating sporozoite vaccine to prevent Plasmodium falciparum malaria. Hum Vaccin 2010; 6:97-106. 35. Genton B, D'Acremont V, Lurati-Ruiz F et al. Randomized double-blind controlled Phase I/IIa trial to assess the efficacy of malaria vaccine PfCS102 to protect against challenge with P. falciparum. Vaccine 2010; 28:6573-6580. 36. Trape JF, Zoulani A. Malaria and urbanization in central Africa: the example of Brazzaville. Part II: Results of entomological surveys and epidemiological analysis. Trans R Soc Trop Med Hyg 1987; 81 Suppl 2:10-18. 37. Moorthy VS, Diggs C, Ferro S et al. Report of a consultation on the optimization of clinical challenge trials for evaluation of candidate blood stage malaria vaccines, 18-19 March 2009, Bethesda, MD, USA. Vaccine 2009; 27:5719-5725.
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Comparison of clinical <strong>and</strong> parasitological data from experimental human malaria<br />
challenge trials<br />
15. Webster DP, Dunachie S, Vuola JM et al. Enhanced T cell-mediated <strong>protection</strong><br />
<strong>against</strong> malaria in human challenges by using the recombinant poxviruses FP9<br />
<strong>and</strong> modified vaccinia virus Ankara. Proc Natl Acad Sci U S A 2005; 102:4836-<br />
4841.<br />
16. Walther M, Dunachie S, Keating S et al. Safety, immunogenicity <strong>and</strong> efficacy of a<br />
pre-erythrocytic malaria c<strong>and</strong>idate vaccine, ICC-1132 formulated in Seppic ISA<br />
720. Vaccine 2005; 23:857-864.<br />
17. McConkey SJ, Reece WH, Moorthy VS et al. Enhanced T-cell immunogenicity of<br />
plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara<br />
in humans. Nat Med 2003; 9:729-735.<br />
18. Porter DW, Thompson FM, Berthoud TK et al. A human Phase I/IIa malaria<br />
challenge trial of a polyprotein malaria vaccine. Vaccine 2011; 29:7514-7522.<br />
19. Bousema JT, Roeffen W, van der KM et al. Rapid onset of transmission-reducing<br />
antibodies in javanese migrants exposed to malaria in Papua,Iindonesia. Am J<br />
Trop Med Hyg 2006; 74:425-431.<br />
20. Ponnudurai T, Lensen AH, van Gemert GJ, Bensink MP, Bolmer M, Meuwissen<br />
JH. Infectivity of cultured Plasmodium falciparum gametocytes to mosquitoes.<br />
Parasitology 1989; 98 Pt 2:165-173.<br />
21. Nieman AE, de MQ, Roestenberg M et al. Cardiac complication after<br />
experimental human malaria <strong>infection</strong>: a case report. Malar J 2009; 8:277.<br />
22. Visser HK. <strong>Experimental</strong> malaria in human volunteers: ethical aspects. Neth J<br />
Med 2005; 63:41-42.<br />
23. de Mast Q, Groot E, Lenting PJ et al. Thrombocytopenia <strong>and</strong> release of activated<br />
von Willebr<strong>and</strong> Factor during early Plasmodium falciparum malaria. J Infect Dis<br />
2007; 196:622-628.<br />
24. de Mast Q, de Groot PG, van Heerde WL et al. Thrombocytopenia in early<br />
malaria is associated with GP1b shedding in absence of systemic platelet<br />
activation <strong>and</strong> consumptive coagulopathy. Br J Haematol 2010; 151:495-503.<br />
25. Ali H, Ahsan T, Mahmood T, Bakht SF, Farooq MU, Ahmed N. Parasite density<br />
<strong>and</strong> the spectrum of clinical illness in falciparum malaria. J Coll Physicians Surg<br />
Pak 2008; 18:362-368.<br />
26. Beier JC, Davis JR, Vaughan JA, Noden BH, Beier MS. Quantitation of<br />
Plasmodium falciparum sporozoites transmitted in vitro by experimentally<br />
infected Anopheles gambiae <strong>and</strong> Anopheles stephensi. Am J Trop Med Hyg<br />
1991; 44:564-570.<br />
27. Jin Y, Kebaier C, V<strong>and</strong>erberg J. Direct microscopic quantification of dynamics of<br />
Plasmodium berghei sporozoite transmission from mosquitoes to mice. Infect<br />
Immun 2007; 75:5532-5539.<br />
28. Frischknecht F, Baldacci P, Martin B et al. Imaging movement of malaria<br />
parasites during transmission by Anopheles mosquitoes. Cell Microbiol 2004;<br />
6:687-694.<br />
29. Pumpuni CB, Mendis C, Beier JC. Plasmodium yoelii sporozoite infectivity varies<br />
as a function of sporozoite loads in Anopheles stephensi mosquitoes. J Parasitol<br />
1997; 83:652-655.<br />
115