Experimental infection and protection against ... - TI Pharma

Comparison of clinical and parasitological data from experimental human malaria
challenge trials
Figure 2: Geometric mean parasite density by Q-PCR per cohort
Three cohorts are depicted RUNMC I (orange), RUNMC II (blue) and Oxford
(green).
No abnormalities of urea and creatinine were found, but USMMVP reported six
cases of haemoglobinuria and one case of proteinuria [6]. Urinary parameters
were not checked in Oxford or RUNMC. Incidental increases particularly in
alanine aminotransferase and aspartate aminotransferase were reported in both
RUNMC and USMMVP. Severe increases (>2.5x ULN) were found in five cases,
three from USMMVP (twice at day 10, once at day 14-16) and two from RUNMC
II (day 16 and 17). All tests normalized at the end of the trial.
Parasitemia by microscopy
Prepatent period between the four cohorts was significantly different (Kruskall-
Wallis p