Experimental infection and protection against ... - TI Pharma

106 Chapter 5
Figure 1. Time to microscopically detected parasitemia by cohort
Survival curve for four cohorts: RUNMC I (orange), RUNMC II (blue), USMMVP
(grey) and Oxford (green).
Unsolicited adverse events were infrequent and never severe, and all resolved
spontaneously. Events included vasovagal collapse, epistaxis, flatulence,
insomnia, tinnitus, hyperesthesia, psychiatric complaints associated with
chloroquine [7], pleuritic chest pain, sore throat, migraine, gingivitis,
palpitations, numbness in fingers, dizziness, drowsiness, photosensitivity and
stiff neck.
Laboratory safety parameters
Clinical laboratory parameters in RUNMC and USMMVP did not show significant
abnormalities in haemoglobin content; parameters were not routinely available
in Oxford. The majority of volunteers experienced a mild to moderate decrease
in leucocyte count, none of which was severe (