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Reference List TRAIL‐induced migration and invasion 1. Field JK, Duffy SW. Lung cancer screening: the way forward. Br J Cancer 2008; 99(4):557‐ 562. 2. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin 2010; 60(5):277‐ 300. 3. Herbst RS, Heymach JV, Lippman SM. Lung cancer. N Engl J Med 2008; 359(13):1367‐1380. 4. Gonzalvez F, Ashkenazi A. New insights into apoptosis signaling by Apo2L/TRAIL. Oncogene 2010; 29(34):4752‐4765. 5. Stegehuis JH, de Wilt LH, de Vries EG, Groen HJ, de Jong S, Kruyt FA. TRAIL receptor targeting therapies for non‐small cell lung cancer: current status and perspectives. Drug Resist Updat 2010; 13(1‐2):2‐15. 6. Newsom‐Davis T, Prieske S, Walczak H. Is TRAIL the holy grail of cancer therapy? Apoptosis 2009; 14(4):607‐623. 7. Jin Z, El‐Deiry WS. Distinct signaling pathways in T. Mol Cell Biol 2006; 26(21):8136‐8148. 8. Varfolomeev E, Maecker H, Sharp D, Lawrence D, Renz M, Vucic D et al. Molecular determinants of kinase pathway activation by Apo2 ligand/tumor necrosis factor‐related apoptosis‐inducing ligand. J Biol Chem 2005; 280(49):40599‐40608. 9. Declercq W, Vanden BT, Vandenabeele P. RIP kinases at the crossroads of cell death and survival. Cell 2009; 138(2):229‐232. 10. Meylan E, Tschopp J. The RIP kinases: crucial integrators of cellular stress. Trends Biochem Sci 2005; 30(3):151‐159. 11. Hoogwater FJ, Nijkamp MW, Smakman N, Steller EJ, Emmink BL, Westendorp BF et al. Oncogenic K‐Ras turns death receptors into metastasis‐promoting receptors in human and mouse colorectal cancer cells. Gastroenterology 2010; 138(7):2357‐2367. 12. Trauzold A, Siegmund D, Schniewind B, Sipos B, Egberts J, Zorenkov D et al. TRAIL promotes metastasis of human pancreatic ductal adenocarcinoma. Oncogene 2006; 25(56):7434‐7439. 13. Bijnsdorp IV, Capriotti F, Kruyt FA, Losekoot N, Fukushima M, Griffioen AW et al. Thymidine phosphorylase in cancer cells stimulates human endothelial cell migration and invasion by the secretion of angiogenic factors. Br J Cancer 2011; 104(7):1185‐1192. 14. Yarrow JC, Perlman ZE, Westwood NJ, Mitchison TJ. A high‐throughput cell migration assay using scratch wound healing, a comparison of image‐based readout methods. BMC Biotechnol 2004; 4:21. 15. Parikh K, Peppelenbosch MP, Ritsema T. Kinome profiling using peptide arrays in eukaryotic cells. Methods Mol Biol 2009; 527:269‐80, x. 16. van Baal JW, Diks SH, Wanders RJ, Rygiel AM, Milano F, Joore J et al. Comparison of kinome profiles of Barrett's esophagus with normal squamous esophagus and normal gastric cardia. Cancer Res 2006; 66(24):11605‐11612. 17. Fuhler GM, Diks SH, Peppelenbosch MP, Kerr WG. Widespread deregulation of phosphorylation‐based signaling pathways in multiple myeloma cells: opportunities for therapeutic intervention. Mol Med 2011; 17(7‐8):790‐798. 18. Brummelkamp TR, Bernards R, Agami R. Stable suppression of tumorigenicity by virus‐ mediated RNA interference. Cancer Cell 2002; 2(3):243‐247. 19. van Leuken R, Clijsters L, van ZW, Lim D, Yao X, Wolthuis RM et al. Polo‐like kinase‐1 controls Aurora A destruction by activating APC/C‐Cdh1. PLoS One 2009; 4(4):e5282. 20. Janmaat ML, Kruyt FA, Rodriguez JA, Giaccone G. Response to epidermal growth factor receptor inhibitors in non‐small cell lung cancer cells: limited antiproliferative effects and absence of apoptosis associated with persistent activity of extracellular signal‐regulated kinase or Akt kinase pathways. Clin Cancer Res 2003; 9(6):2316‐2326. 21. Reis CR, van der Sloot AM, Natoni A, Szegezdi E, Setroikromo R, Meijer M et al. Rapid and efficient cancer cell killing mediated by high‐affinity death receptor homotrimerizing TRAIL ‐ 79 ‐

Chapter 4 variants. Cell Death Dis 2010; 1:e83. 22. van der Sloot AM, Tur V, Szegezdi E, Mullally MM, Cool RH, Samali A et al. Designed tumor necrosis factor‐related apoptosis‐inducing ligand variants initiating apoptosis exclusively via the DR5 receptor. Proc Natl Acad Sci U S A 2006; 103(23):8634‐8639. 23. Voortman J, Resende TP, bou El Hassan MA, Giaccone G, Kruyt FA. TRAIL therapy in non‐ small cell lung cancer cells: sensitization to death receptor‐mediated apoptosis by proteasome inhibitor bortezomib. Mol Cancer Ther 2007; 6(7):2103‐2112. 24. Falschlehner C, Emmerich CH, Gerlach B, Walczak H. TRAIL signalling: decisions between life and death. Int J Biochem Cell Biol 2007; 39(7‐8):1462‐1475. 25. Johnson FM, Saigal B, Talpaz M, Donato NJ. Dasatinib (BMS‐354825) tyrosine kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non‐small cell lung cancer cells. Clin Cancer Res 2005; 11(19 Pt 1):6924‐6932. 26. Purnell PR, Mack PC, Tepper CG, Evans CP, Green TP, Gumerlock PH et al. The Src inhibitor AZD0530 blocks invasion and may act as a radiosensitizer in lung cancer cells. J Thorac Oncol 2009; 4(4):448‐454. 27. Spierings DC, de Vries EG, Timens W, Groen HJ, Boezen HM, de Jong S. Expression of TRAIL and TRAIL death receptors in stage III non‐small cell lung cancer tumors. Clin Cancer Res 2003; 9(9):3397‐3405. 28. Gallick GE. SRC as a potential therapeutic target in solid tumor oncology. Clin Adv Hematol Oncol 2004; 2(7):435‐437. 29. Mazurenko NN, Kogan EA, Zborovskaya IB, Kisseljov FL. Expression of pp60c‐src in human small cell and non‐small cell lung carcinomas. Eur J Cancer 1992; 28(2‐3):372‐377. 30. Guarino M. Src signaling in cancer invasion. J Cell Physiol 2010; 223(1):14‐26. 31. Mukhopadhyay UK, Mooney P, Jia L, Eves R, Raptis L, Mak AS. Doubles game: Src‐Stat3 versus p53‐PTEN in cellular migration and invasion. Mol Cell Biol 2010; 30(21):4980‐4995. 32. Abdulghani J, Gu L, Dagvadorj A, Lutz J, Leiby B, Bonuccelli G et al. Stat3 promotes metastatic progression of prostate cancer. Am J Pathol 2008; 172(6):1717‐1728. 33. Teng TS, Lin B, Manser E, Ng DC, Cao X. Stat3 promotes directional cell migration by regulating Rac1 activity via its activator betaPIX. J Cell Sci 2009; 122(Pt 22):4150‐4159. 34. Snyder M, Huang XY, Zhang JJ. Signal transducers and activators of transcription 3 (STAT3) directly regulates cytokine‐induced fascin expression and is required for breast cancer cell migration. J Biol Chem 2011; 286(45):38886‐38893. 35. Boyer B, Bourgeois Y, Poupon MF. Src kinase contributes to the metastatic spread of carcinoma cells. Oncogene 2002; 21(15):2347‐2356. 36. Kalluri R, Weinberg RA. The basics of epithelial‐mesenchymal transition. J Clin Invest 2009; 119(6):1420‐1428. 37. van Nimwegen MJ, van de WB. Focal adhesion kinase: a potential target in cancer therapy. Biochem Pharmacol 2007; 73(5):597‐609. 38. Cursi S, Rufini A, Stagni V, Condo I, Matafora V, Bachi A et al. Src kinase phosphorylates Caspase‐8 on Tyr380: a novel mechanism of apoptosis suppression. EMBO J 2006; 25(9):1895‐1905. 39. Ishimura N, Isomoto H, Bronk SF, Gores GJ. Trail induces cell migration and invasion in apoptosis‐resistant cholangiocarcinoma cells. Am J Physiol Gastrointest Liver Physiol 2006; 290(1):G129‐G136. 40. Song JH, Tse MC, Bellail A, Phuphanich S, Khuri F, Kneteman NM et al. Lipid rafts and nonrafts mediate tumor necrosis factor related apoptosis‐inducing ligand induced apoptotic and non‐apoptotic signals in non small cell lung carcinoma cells. Cancer Res 2007; 67(14):6946‐6955. 41. Song JJ, Kim JH, Sun BK, Alcala MA, Jr., Bartlett DL, Lee YJ. c‐Cbl acts as a mediator of Src‐ induced activation of the PI3K‐Akt signal transduction pathway during TRAIL treatment. ‐ 80 ‐

Chapter 4<br />

variants. Cell Death Dis 2010; 1:e83.<br />

22. van der Sloot AM, Tur V, Szegezdi E, Mullally MM, Cool RH, Samali A et al. Designed tumor<br />

necrosis factor‐related apoptosis‐inducing ligand variants initiating apoptosis exclusively<br />

via the DR5 <strong>receptor</strong>. Proc Natl Acad Sci U S A 2006; 103(23):8634‐8639.<br />

23. Voortman J, Resende TP, bou El Hassan MA, Giaccone G, Kruyt FA. TRAIL <strong>therapy</strong> in non‐<br />

small cell lung cancer cells: sensitization to <strong>death</strong> <strong>receptor</strong>‐mediated apoptosis by<br />

proteasome inhibitor bortezomib. Mol Cancer Ther 2007; 6(7):2103‐2112.<br />

24. Falschlehner C, Emmerich CH, Gerlach B, Walczak H. TRAIL signalling: decisions between<br />

life and <strong>death</strong>. Int J Biochem Cell Biol 2007; 39(7‐8):1462‐1475.<br />

25. Johnson FM, Saigal B, Talpaz M, Donato NJ. Dasatinib (BMS‐354825) tyrosine kinase<br />

inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck<br />

squamous cell carcinoma and non‐small cell lung cancer cells. Clin Cancer Res 2005; 11(19<br />

Pt 1):6924‐6932.<br />

26. Purnell PR, Mack PC, Tepper CG, Evans CP, Green TP, Gumerlock PH et al. The Src inhibitor<br />

AZD0530 blocks invasion and may act as a radiosensitizer in lung cancer cells. J Thorac<br />

Oncol 2009; 4(4):448‐454.<br />

27. Spierings DC, de Vries EG, Timens W, Groen HJ, Boezen HM, de Jong S. Expression of TRAIL<br />

and TRAIL <strong>death</strong> <strong>receptor</strong>s in stage III non‐small cell lung cancer tumors. Clin Cancer Res<br />

2003; 9(9):3397‐3405.<br />

28. Gallick GE. SRC as a potential therapeutic target in solid tumor oncology. Clin Adv Hematol<br />

Oncol 2004; 2(7):435‐437.<br />

29. Mazurenko NN, Kogan EA, Zborovskaya IB, Kisseljov FL. Expression of pp60c‐src in human<br />

small cell and non‐small cell lung carcinomas. Eur J Cancer 1992; 28(2‐3):372‐377.<br />

30. Guarino M. Src signaling in cancer invasion. J Cell Physiol 2010; 223(1):14‐26.<br />

31. Mukhopadhyay UK, Mooney P, Jia L, Eves R, Raptis L, Mak AS. Doubles game: Src‐Stat3<br />

versus p53‐PTEN in cellular migration and invasion. Mol Cell Biol 2010; 30(21):4980‐4995.<br />

32. Abdulghani J, Gu L, Dagvadorj A, Lutz J, Leiby B, Bonuccelli G et al. Stat3 promotes<br />

metastatic progression of prostate cancer. Am J Pathol 2008; 172(6):1717‐1728.<br />

33. Teng TS, Lin B, Manser E, Ng DC, Cao X. Stat3 promotes directional cell migration by<br />

regulating Rac1 activity via its activator betaPIX. J Cell Sci 2009; 122(Pt 22):4150‐4159.<br />

34. Snyder M, Huang XY, Zhang JJ. Signal transducers and activators of transcription 3 (STAT3)<br />

directly regulates cytokine‐induced fascin expression and is required <strong>for</strong> breast cancer cell<br />

migration. J Biol Chem 2011; 286(45):38886‐38893.<br />

35. Boyer B, Bourgeois Y, Poupon MF. Src kinase contributes to the metastatic spread of<br />

carcinoma cells. Oncogene 2002; 21(15):2347‐2356.<br />

36. Kalluri R, Weinberg RA. The basics of epithelial‐mesenchymal transition. J Clin Invest 2009;<br />

119(6):1420‐1428.<br />

37. van Nimwegen MJ, van de WB. Focal adhesion kinase: a potential target in cancer <strong>therapy</strong>.<br />

Biochem <strong>Pharma</strong>col 2007; 73(5):597‐609.<br />

38. Cursi S, Rufini A, Stagni V, Condo I, Mata<strong>for</strong>a V, Bachi A et al. Src kinase phosphorylates<br />

Caspase‐8 on Tyr380: a novel mechanism of apoptosis suppression. EMBO J 2006;<br />

25(9):1895‐1905.<br />

39. Ishimura N, Isomoto H, Bronk SF, Gores GJ. Trail induces cell migration and invasion in<br />

apoptosis‐resistant cholangiocarcinoma cells. Am J Physiol Gastrointest Liver Physiol 2006;<br />

290(1):G129‐G136.<br />

40. Song JH, Tse MC, Bellail A, Phuphanich S, Khuri F, Kneteman NM et al. Lipid rafts and<br />

nonrafts mediate tumor necrosis factor related apoptosis‐inducing ligand induced<br />

apoptotic and non‐apoptotic signals in non small cell lung carcinoma cells. Cancer Res<br />

2007; 67(14):6946‐6955.<br />

41. Song JJ, Kim JH, Sun BK, Alcala MA, Jr., Bartlett DL, Lee YJ. c‐Cbl acts as a mediator of Src‐<br />

induced activation of the PI3K‐Akt signal transduction pathway during TRAIL treatment.<br />

‐ 80 ‐

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