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Chapter 2<br />

and ERK pathways. Circulation 2003; 107(17):2250‐2256.<br />

109. Li JH, Kirkiles‐Smith NC, McNiff JM, Pober JS. TRAIL induces apoptosis and inflammatory<br />

gene expression in human endothelial cells. J Immunol 2003; 171(3):1526‐1533.<br />

110. Secchiero P, Corallini F, di Iasio MG, Gonelli A, Barbarotto E, Zauli G. TRAIL counteracts the<br />

proadhesive activity of inflammatory cytokines in endothelial cells by down‐modulating<br />

CCL8 and CXCL10 chemokine expression and release. Blood 2005; 105(9):3413‐3419.<br />

111. Wilson NS, Yang A, Yang B, Couto S, Stern H, Gogineni A et al. Proapoptotic activation of<br />

<strong>death</strong> <strong>receptor</strong> 5 on tumor endothelial cells disrupts the vasculature and reduces tumor<br />

growth. Cancer Cell 2012; 22(1):80‐90.<br />

112. Secchiero P, Zerbinati C, Rimondi E, Corallini F, Milani D, Grill V et al. TRAIL promotes the<br />

survival, migration and proliferation of vascular smooth muscle cells. Cell Mol Life Sci<br />

2004; 61(15):1965‐1974.<br />

113. Kavurma MM, Schoppet M, Bobryshev YV, Khachigian LM, Bennett MR. TRAIL stimulates<br />

proliferation of vascular smooth muscle cells via activation of NF‐kappaB and induction of<br />

insulin‐like growth factor‐1 <strong>receptor</strong>. J Biol Chem 2008; 283(12):7754‐7762.<br />

114. Chan J, Prado‐Lourenco L, Khachigian LM, Bennett MR, Di Bartolo BA, Kavurma MM. TRAIL<br />

promotes VSMC proliferation and neointima <strong>for</strong>mation in a FGF‐2‐, Sp1 phosphorylation‐,<br />

and NFkappaB‐dependent manner. Circ Res 2010; 106(6):1061‐1071.<br />

115. Chou AH, Tsai HF, Lin LL, Hsieh SL, Hsu PI, Hsu PN. Enhanced proliferation and increased<br />

IFN‐gamma production in T cells by signal transduced through TNF‐related apoptosis‐<br />

inducing ligand. J Immunol 2001; 167(3):1347‐1352.<br />

116. Robertson NM, Zangrilli JG, Steplewski A, Hastie A, Lindemeyer RG, Planeta MA et al.<br />

Differential expression of TRAIL and TRAIL <strong>receptor</strong>s in allergic asthmatics following<br />

segmental antigen challenge: evidence <strong>for</strong> a role of TRAIL in eosinophil survival. J Immunol<br />

2002; 169(10):5986‐5996.<br />

117. Morel J, Audo R, Hahne M, Combe B. Tumor necrosis factor‐related apoptosis‐inducing<br />

ligand (TRAIL) induces rheumatoid arthritis synovial fibroblast proliferation through<br />

mitogen‐activated protein kinases and phosphatidylinositol 3‐kinase/Akt. J Biol Chem<br />

2005; 280(16):15709‐15718.<br />

118. Rimondi E, Secchiero P, Quaroni A, Zerbinati C, Capitani S, Zauli G. Involvement of<br />

TRAIL/TRAIL‐<strong>receptor</strong>s in human intestinal cell differentiation. J Cell Physiol 2006;<br />

206(3):647‐654.<br />

119. Wu NL, Lee TA, Tsai TL, Lin WW. TRAIL‐induced keratinocyte differentiation requires<br />

caspase activation and p63 expression. J Invest Dermatol 2011; 131(4):874‐883.<br />

120. Yen ML, Tsai HF, Wu YY, Hwa HL, Lee BH, Hsu PN. TNF‐related apoptosis‐inducing ligand<br />

(TRAIL) induces osteoclast differentiation from monocyte/macrophage lineage precursor<br />

cells. Mol Immunol 2008; 45(8):2205‐2213.<br />

121. Kim JY, Lee JY, Kim DG, Koo GB, Yu JW, Kim YS. TRADD is critical <strong>for</strong> resistance to TRAIL‐<br />

induced cell <strong>death</strong> through NF‐kappaB activation. FEBS Lett 2011; 585(14):2144‐2150.<br />

122. Lluis JM, Nachbur U, Cook WD, Gentle IE, Moujalled D, Moulin M et al. TAK1 is required <strong>for</strong><br />

survival of mouse fibroblasts treated with TRAIL, and does so by NF‐kappaB dependent<br />

induction of cFLIPL. PLoS One 2010; 5(1):e8620.<br />

123. Cao X, Pobezinskaya YL, Morgan MJ, Liu ZG. The role of TRADD in TRAIL‐induced apoptosis<br />

and signaling. FASEB J 2011; 25(4):1353‐1358.<br />

124. Jurewicz A, Matysiak M, Andrzejak S, Selmaj K. TRAIL‐induced <strong>death</strong> of human adult<br />

oligodendrocytes is mediated by JNK pathway. Glia 2006; 53(2):158‐166.<br />

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