Design of in vitro protein digestibility d h i l h i k assays ... - Europabio
Design of in vitro protein digestibility d h i l h i k assays ... - Europabio
Design of in vitro protein digestibility d h i l h i k assays ... - Europabio
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Is the peps<strong>in</strong> resistance test more a biochemical<br />
surrogate <strong>of</strong> “stability” than simulated gastric digestion?<br />
•Peps<strong>in</strong>, like other endoproteases (tryps<strong>in</strong>, chymotryps<strong>in</strong>)<br />
cleaves mobile, surface accessible sites on a substrate<br />
•Resistance to peps<strong>in</strong>olysis is a function <strong>of</strong><br />
•Resistance Resistance to low pH unfold<strong>in</strong>g<br />
•Polypeptide mobility at the cleavage site<br />
•Resistance to peps<strong>in</strong> maybe a surrogate measure <strong>of</strong><br />
endosomal process<strong>in</strong>g <strong>in</strong>volved <strong>in</strong> antigen presentation<br />
•It may hhave validity ld as a correlative l test def<strong>in</strong>ed df dus<strong>in</strong>g<br />
panels <strong>of</strong> “allergens” and “non‐allergens” <strong>in</strong>cluded <strong>in</strong> the<br />
i<strong>in</strong>tegrative i risk ikassessment approach<br />
h
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