2008 Barcelona - European Society of Human Genetics

Molecular and biochemical basis of disease
with psoriasis vulgaris (PV) have been demonstrated in different racial
or ethnic populations . To identify special haplotypes in Russian
population that may contribute to the genetic susceptibility to PV, we
investigated the distribution of the associated haplotypes in Russian
cohort . 407 patients with PV and 418 controls were genotyped
for HLA-Cw6, HCR-C325T, HCR-A1911G and CDSN-C1243T SNPs .
The results showed: HLA-Cw6 and HCR-C325T, HLA-Cw6 and HCR-
A1911G were in strong linkage disequilibrium (LD) (D’=0 .67, r²=0 .4
in all subjects and D’=0 .66, r²=0 .37 in patients; D’=0 .87, r²=0 .13 in all
subjects and D’=0 .88, r²=0 .16 in patients, respectively), whereas LD
was weaker between HCR-C325T and CDSN-C1243T; HCR-A1911G
and CDSN-C1243T (D’=0 .28, r²=0 .024 in all subjects and D’=0 .13,
r²=0 .007 in patients and D’=0 .17, r²=0 .019 in all subjects and D’=0 .10,
r²=0 .006 in patients, respectively), suggesting a relative recombination
hot-spot between HCR and CDSN . Cw6/HCR-325*T/HCR-1911*G/
CDSN-1243*C(β=1.5, P