2008 Barcelona - European Society of Human Genetics

Molecular and biochemical basis of disease
males carrying 6A/6A genotype in the MMP-3 promoter region .
P06.165
matrix metalloproteinase-9 polymorphism in relation to
cardiovascular disease complications in patients of type 2
diabetes mellitus
E. Kurvinen 1,2 , K. Nueganen 3 , M. Viigimaa 4 , A. Veske 3 , K. Aasvee 1 ;
1 National Institute for Health Development, Tallinn, Estonia, 2 Tallinn Children`s
Hospital, Tallinn, Estonia, 3 Tallinn Technical University, Tallinn, Estonia, 4 North
Estonia Regional Hospital, Tallinn, Estonia.
The process of atherosclerosis is accelerated in patients of type 2 Diabetes
Mellitus (T2DM) . The traditional risk factors alone cannot explain
the excess incidence of cardiovascular complications in T2DM patients .
The matrix metalloproteinase 9 (MMP-9) gene promoter genotype
was considered to be related to coronary artery disease . Our study
aimed to evaluate possible role of C-1562T MMP-9 polymorphism in
developing of cardiovascular complications among T2DM patients . We
have studied 111 subjects with C/C (group 1) and 50 subjects with T/T
(in 1 patient) or C/T genotype (group 2) . Fasting serum glucose and
lipid metabolism parameters, inflammatory markers and anthropometric
data were measured . MMP-9 genotype was detected by the PCR
method . Cardiovascular complications were proven angiographically .
Results . A cardiovascular complication was detected in 45% among
C/C homozygotes and 48% among patients of group 2 (C/T+T/T) .
Waist/hip ratio and diastolic blood pressure were significantly higher in
T allele carriers (p